IDENTIFICATION OF COMMON DIFFERENTIALLY EXPRESSED GENES (DEGS) AND HUB GENES IN NEURODEGENERATIVE DISEASES: A COMPARATIVE STUDY OF ALZHEIMER'S AND PARKINSON'S USING EXTENSIVE DATA MINING
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Keywords
Neurodegenerative Diseases, Hub genes, Biomarker, Treatment
Abstract
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent neurodegenerative disorders, sharing overlapping pathophysiological mechanisms. This study aims to identify common differentially expressed genes (DEGs) and hub genes between AD and PD using publicly available datasets from the Gene Expression Omnibus (GEO). We utilized datasets GSE5281 for AD and GSE49036 for PD to conduct a comparative analysis. After normalization and differential expression analysis, common DEGs were identified, followed by protein-protein interaction (PPI) network construction using the STRING database. Hub genes were extracted through Cytoscape's cytoHubba plugin based on centrality measures. The results highlight shared molecular pathways and key hub genes, including MAPT, SNCA, APP, and KLHL2, which may serve as potential therapeutic targets for both diseases. These findings contribute to a better understanding of the common molecular landscape in neurodegenerative diseases and open avenues for novel treatment strategies.
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Muhammad Afzal
Department of Biochemistry, Faisalabad Medical University, Faisalabad, Pakistan
Ayesha Arif
Punjab Rangers Teaching Hospital, Lahore, Pakistan
Aqeela Iqbal
Jinnah Hospital Lahore, Pakistan
Abdullah Sethar
Livestock Breeding Services Authority (LBSA) Sindh, Livestock & Fisheries Department, Government of Sindh, Pakistan
Mumtaz Ali Lakho
Department of Medicine, Liaquat University of Medical and Health Sciences Jamshoro, Pakistan
Hamza Yaseen
Ghurki Trust and Teaching Hospital, Lahore, Pakistan
Kinza Khan
Department of Microbiology, Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Pakistan
Nimra Arshad
Department of Biochemistry, Institute of Chemistry, GC University, Faisalabad, Pakistan
Tamseel Saleem
Department of Physiology and Biochemistry, Faculty of Animal Husbandry and Veterinary Sciences (AHVS), Sindh Agriculture University, Tandojam, Pakistan
Iqra M.Arshad
Allied Health Sciences, University of Sialkot, Pakistan
Habibullah Janyaro
Department of Veterinary Surgery, SBBUVAS, Sakrand, Pakistan