THE UP-REGULATED CUL7 GENE IS ASSOCIATED WITH PATHOGENESIS, METASTASIS, AND LOW SURVIVAL RATES IN LIVER HEPATOCELLULAR CARCINOMA PATIENTS

Main Article Content

Muhammad Ejaz
Sanobar Gull
Huma Umbreen
Farhana Noureen
Syeda Amber Hameed
Qudratullah Kalwar
Reema Bughio
Muhammad Arif Rizwan
Junaid Farooq
Habibullah Janyaro
I Made Dwi Mertha Adnyana

Keywords

CUL7, LIHC, Metastasis, Prognosis

Abstract

The investigation focused on exploring the role of CUL7 genes in Liver Hepatocellular Carcinoma (LIHC) development and progression. Utilizing the UALCAN database, a significant up-regulation of CUL7 expression was observed in LIHC tissues, suggesting its potential involvement in the development of LIHC. Subsequent analysis across various clinical parameters revealed consistent up-regulation of CUL7 expression in LIHC, regardless of cancer stage, patient gender, age, or racial background. Furthermore, promoter methylation analysis indicated hypermethylation of the CUL7 promoter in LIHC samples compared to normal controls, implying potential epigenetic dysregulation of CUL7 in LIHC pathogenesis. Notably, differences in promoter methylation levels were observed across different cancer stages, patient genders, ages, and racial groups, highlighting the complex relationship between CUL7 promoter methylation and various clinical parameters in LIHC. Additionally, survival analysis demonstrated a significant association between CUL7 expression levels and patient overall survival, with high CUL7 expression correlating with shorter survival rates in LIHC patients. However, mutational analysis using the cBioPortal platform did not reveal significant mutations in CUL7 in LIHC samples. Overall, these findings shed light on the potential role of CUL7 as a biomarker and therapeutic target in LIHC management, emphasizing its clinical significance in prognostic assessment and personalized treatment strategies.


 

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