DECIPHERING THE ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (VEGFA) IN COLON ADENOCARCINOMA PROGRESSION: A COMPREHENSIVE BIOINFORMATICS ANALYSIS

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Imtiaz Ali Soomro
Muhammad Abbas
Habibullah Janyaro
Ayesha Siddiquie
Khizar Hayyat
Ishtiaq Hussain
Sanobar Gull
Muhammad Arif Rizwan
Barkat Ali Jatoi
Erum Bughio

Keywords

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Abstract

The study investigated the expression pattern and potential role of VEGFA in colon adenocarcinoma (COAD) using bioinformatics tools and databases. Initially, UALCAN analysis revealed a significant up-regulation of VEGFA expression in COAD samples compared to normal controls, indicating its involvement in COAD pathogenesis. This finding was further validated using GEPIA2, further emphasizing the overexpression of VEGFA in COAD. Subsequent analysis across different parameters such as cancer stage, patient race, gender, and age consistently showed significant overexpression of VEGFA, highlighting its potential role in COAD progression. Additionally, promoter methylation analysis demonstrated hypermethylation of VEGFA in COAD samples, suggesting its aberrant regulation in cancer development. The association between VEGFA expression and overall survival (OS) was examined using KM plotter, revealing that higher VEGFA expression is associated with poor OS in COAD patients. Furthermore, genetic alteration analysis via cBioPortal indicated a low frequency of genetic mutations in VEGFA, with amplification being the most common mutation type. Overall, these findings suggest that VEGFA overexpression may contribute to the progression and development of COAD, emphasizing the need for further research to elucidate its precise role and potential therapeutic implications.

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