A COMPREHENSIVE REVIEW AND ANALYSIS OF FACTORS INFLUENCING DRUG INTERACTIONS: UNRAVELING THE COMPLEXITY FOR ENHANCED PATIENT SAFETY

Abstract

Background: This extensive overview explores the numerous aspects of the multiple and complex combinations of factors which impinge on drug interactions; an essay that seeks to dissect the myths which surround this important aspect of pharmacology. Over half of all hospital patients are at risk of at least one significant drug interaction which is a huge patient safety issue highlighting the need for an understanding of the many faceted factors, which comprise this issue.

Aim: The main aim of this work was to undertake a systematic review and synthesis of the different causes of drug interactions. By such an understanding, the goal is to improve patient safety in matters to do with pharmaceutical interactions. In a stepwise approach specific factors predisposing to the development of drug interaction were aimed to be elucidated in this study.

Methods: A literature search of all the research articles, clinical and pharmacological research and databases were undertaken. This search, which involved such parameters as drug metabolism, pharmacokinetic and pharmacodynamic parameters, as well as the factors specific to the patient. This factor analysis also considered the possibility of synergy between these factors in various therapeutic applications which gave the study a comprehensive look into the subject under investigation and established the fact that drug interactions are complex.

Results: There is an array of manners through which diagonized drug interactions occurred that was embraced in the review such as metabolic pathways, cytochrome P450 enzymes, drug transporter, and lastly genetic differences across the patients. Likewise, age, different diseases, and concurrent prescription medications as aspects that propagate the problem of numerous drug interactions. These findings support the argument of a patient-individualized and a multimodal strategy for tackling the potential bad interactions as effectively as possible.

Conclusion: This paper presents the first and only detailed insight of drug interactions, the various factors and complex relationships of all the cancers of drugs. In this way, there is a possibility to raise awareness of the existing and potential complexities and make accurate decisions for improving patient safety for healthcare practitioners. In this respect, the outcomes determinant the implementation of FPMA strategies and the development of interprofessional collaborations for the effective delivery of personal medicine framework.