ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR CONTROL OF PH AND ELECTRICAL CONDUCTIVITY IN SALBUTAMOL SOLUTIONS
Main Article Content
Keywords
Method Development, Validation, control of in salbutamol solutions, control of electrical conductivity in salbutamol solutions
Abstract
Analytical method development and validation play an important role in the discovery, development, and manufacturing of pharmaceuticals. The process validation is of utmost importance while manufacturing a quality product. Salbutamol sulfate (SBS) is a very potent bronchodilator and is used extensively for treating different respiratory problems such as bronchial congestion, asthma and Chronic Obstructive Pulmonary Disease (COPD), etc. In this study, a method of need was developed for prospects to be used for better advances in solution stability and preservation by controlling pH and electrical conductivity. This method was developed using a pH/conductivity meter of accuracy ±0.02 and all procedures were done by maintaining the temperature of the solution at 25°C. The de-ionized water was used as a solvent to minimize any contaminant ions activity. During method development, the development, measurement and validation of the pH and electrical conductivity were performed. For developing a method for control the pH value of the solution was maintained at 5.00 so that the results show that the method developed is precise and accurate. Different validation parameters were studied such as linearity, accuracy, precision and robustness. The method was validated according to standard guidelines. The routine calibration of the pH/conductivity meter was done to obtain accurate readings and to avoid any mishandling of any step throughout the process. The results were precise and showed that the method developed is accurate. The method developed is suitable for the control of pH and electrical conductivity for the different solutions as these characteristics are necessary for their stability, quality and efficacy. The method developed is precise, stable and also enhances the action of salbutamol sulfate. It can serve as a new window for researchers to analyze and control the pH and conductivity of different formulations.
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Sidra Rafique
Department of Pharmacy, The Sahara University, Narowal, Pakistan.
Mudassar Mazher
Department of Pharmacy, The University of Chenab, Gujrat, Pakistan.
Abdul Quddoos
Department of Pharmacy, The Sahara University, Narowal, Pakistan.
Kishwar Sultana
Department of Pharmacy, Iqra University, Islamabad, Pakistan.
Syed Hassan Murtaza Naqvi
Yashfeen College of Pharmacy, Lahore, Pakistan.
Muhammad Rehan Malik
Department of Pharmacy, The University of Chenab, Gujrat, Pakistan. Department of Pharmaceutics, Faculty of Pharmacy, Gomal University D.I.Khan, Pakistan.
Zafar Iqbal
College of Pharmacy, Bahawalpur medical And Dental College, Bahawalpur, Pakistan.
Muhammad Shahzad Khan
Abbas Institute of Medical Sciences, GC. University, Layyah Campus, Layyah, Pakistan.
Hosh Muhammad Lashari
Department of Pharmacognosy, Faculty of Pharmacy, University of Sindh, Jamshoro Pakistan.