COMPARATIVE STUDY OF ZINC OXIDE OINTMENT AND ZINC OXIDE NANOPARTICLES AS A POTENTIAL WOUND HEALING SUBSTANCE IN RABBIT
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Keywords
Nanoparticles, Antibacterial, Anticancer, Ointments, Wound Healing
Abstract
Nanotechnology has revolutionized medicine, with a focus on green nanoparticle production that is both friendly to the environment and cost effective. Biogenic nanoparticles have demonstrated great potential in wound healing, especially through nanotechnology drug delivery systems such as micelles, nanoparticles, nanoemulsions, and liposomes. These systems improve wound healing by lowering medication cytotoxicity, increasing skin penetration, and providing antimicrobial protection. Zinc oxide (ZnO) nanoparticles are particularly useful due to their antibacterial and anticancer characteristics. This study addressed the wound healing effects of ZnO nanoparticles in 18 rabbits separated into three groups: control (normal saline), ZnO nanoparticles, and ZnO ointments. Wound contraction size, hematological, and histology were evaluated on days 0, 5, 10, and 15. The results showed that ZnO nanoparticles significantly increased wound contraction and histological parameters such as angiogenesis and re-epithelization when compared to the control and ZnO ointment groups. The hematological study revealed no infection or harm. In conclusion, ZnO nanoparticles have better healing and therapeutic properties than ZnO ointment.
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Maham Tariq
Department of Veterinary Surgery, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
Sadaf Aslam
Department of Veterinary Surgery, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
Danish Jeelani
Department of Veterinary Surgery, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
Muhammad Ahmad
Veterinary Officer/ Livestock Production Officer, Department of Livestock & Dairy Development (Extension) KPK, Pakistan
Huma Maqsood
Department of Veterinary Surgery, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
Rukhshanda Parveen
Department of Veterinary Surgery, University of Veterinary and Animal Sciences Lahore, 54000, Pakistan
Haider Ali Khan
DVM, MPhil/MSc (Hons) Microbiology, PhD (Microbiology). Registrar Breeding Service Authority, Punjab, Lahore, Pakistan
Mahnoor Khan Jamali
DVM, Mphill Veterinary Surgery, Assistant Director, Bhagnari Cattle Cum Balochi Sheep Farm Jaffarabad, Balochistan, Pakistan