EFFECT OF STONE DUST ON THE HEALTH STATUS OF WORKERS IN MARBLE INDUSTRIES OF KHYBER PAKHTUNKHWA, PAKISTAN

Main Article Content

Sulaiman Shams
Fawad Iqbal
Muhammad Ayaz
Haider Ali Khan
Huma Rafiq
Nazia Imran
Maryam Iqbal
Sapna Quraish
Ome Kalsoom Afridi

Keywords

Marble, Stone, Dust, Workers, Bilirubin, creatinine, manganese

Abstract

Various industrial dust pollution causes different health problems in workers including respiratory complaint, eye and skin disorders. Based on the concentration and chemical nature, stone dust also effect the liver and kidney related parameters especially in stone crushing workers. The purpose and aims of this study was to report for the first time the effect of stone dust on the health status of worker in marble industries of Pakistan.  In the current study the effect of stone crushing dust on liver and kidney related serum parameters were estimated among the stone crusher’s workers in marble factories at district Mardan and Charsadda of Khyber Pakhtunkhwa, Pakistan. Blood samples were collected from 180 stone crushing workers (aged 20-60 years), grouped as exposed workers and 180 unexposed healthy persons considered as healthy control. The exposed workers were further classified on the basis of age, time of exposure to stone dust, disease and smoking history.  The liver and kidney related serum biochemical parameters  were evaluated through wet reagent diagnostic kits while a standardized questionnaire was used for risk factors assessment. The results indicate a considerable raise in liver related parameters such as serum Glutamate Pyruvate Transaminase (GPT), bilirubin and manganese in workers, compared to control group. Creatinine results of kidney related serum parameter also confirmed increased levels in exposed workers as compared to healthy control. Overall result indicated that the mean values of liver and kidney related parameters were considerably high (SGTP level 130 ± 5.42U/L, Bilirubin level 1.7 ± 0.13 mg/dl and Cretinine level 2.31 ± 0.14mg/dl)in exposed workers than healthy control (SGTP level27 ± 2.23 U/L,  Bilirubin  level 0.62 ± 0.02 mg/dl and creatinine level 0.82 ± 0.04 mg/dl). The stone dust also leads to improvement in respiratory and skin infection due to lack of protective equipment among manual stone-quarry workers. It is concluded that chronic exposure of workers to stone dust in marble factories induces irregular elevation in the normal value of serum GPT, bilirubin, creatinine and manganese due to hazard effect on liver and kidney and also causes severe medical complications related to skin and respiratory system.

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References

[1] SIVACOUMAR R., JAYABALOU R., SWARNALATHA S., and BALAKRISHNAN K., Particulate Matter from Stone Crushing Industry: Size Distribution and Health Effects, Journal of Environmental Engineering, 2006, 132 (3):405–414.
[2] BURNETT W.C., BOKUNIEWICZ H., MOORE W.S., and TANIGUCHI M., Burnett_2003_Biogeochemistry. Biogeochemistry, 2003, 66, 3–33.
[3] CORINALDESI V., MORICONI G., and NAIK T.R., Characterization of marble powder for its use in mortar and concrete. Construction and Building Materials, 2009, 24 (1):113–117. [4] EL-GAMMAL M.I., IBRAHIM M.S., BADR E.S.A., ASKER S.A., EL-GALAD N.M., and EL N.M., Health Risk Assessment of Marble Dust at Marble Workshops. Natural Sciences, 2011, 9 (11):1545–0740.
[5] Tjoe Nij E., Radiographic abnormalities among construction workers exposed to quartz containing dust. Occupational Environmental Medicine, 2003, 60 (6):410–417.
[6] LEIKIN E., ZICKEL-SHALOM K., BALABIR-GURMAN A., GORALNIK L., and VALDOVSKY E., Caplan’s syndrome in marble workers as occupational disease. Harefuah, 2009, 148 (8):524–6, 572.
[7] OSORIO A.M., THUN M.J., NOVAK R.F., AN CURA E.J., and AVNER E.D., Silica and Glomerulonephritis: Case Report and Review of the Literature. American Journal of Kidney Diseases, 1987, 9 (3):224–230.
[8] Krewski G.D., Snyder R., Beatty P., Assessing the health risks of benzene: a report on the benzene state-of-the-science workshop. Journal Toxicology and Environmenatl Health. Part A, 61, 5–6:307–338.
[9] HALWENGE J.A., Dust Pollution and Its Health Risks Among Rock, 2015, 1–45, 2015.
[10] MILLER B.G., and SEARL A., Epidemiological Evidence on the Carcinogenicity of Silica: Factors in Scientific Judgement, Annals of Occupational Hygiene, 2014, 2000.
[11] ROCHLING F.A., Evaluation of abnormal liver tests. Clin. Cornerstone, 2001, 3 (6):1–12.
[12] CHAUDHARY S.S., SHAH J.P. , and MAHATO R.V., Interference of Bilirubin in Creatinine Value Measurement by Jaffe Kinetic Method, Annals of Clinical Chemistry and Laboratory Medicine, 2015, 1(1): 25–28.
[13] CHATTOPADHYAY B.P., GANGOPADHYAY P.K., BANDOPADHYAY T.S., and ALAM J., Comparison of pulmonary function test abnormalities between stone crushing dust exposed and nonexposed agricultural workers. Environmental health and preventive medicine, 2006, 11:191-8.
[14] GOVINDAGOUDAR M.B., SINGH P.K., CHAUDHRY D., CHAUDHARY R., SACHDEVA A., DHANKHAR S., AND TYAGI D., Burden of Silicosis among stone crushing workers in India. Occupational Medicine, 2022, 72(6):366-71.
[15] TIWARI R.R., SHARMA Y.K., and SAIYED H.N., Tuberculosis among workers exposed to free silica dust. Indian journal of occupational and environmental medicine. 2007, 11(2):61.
[16] KITCHER E.D., OCANSEY G., and TUMPI D.A., Early occupational hearing loss of workers in a stone crushing industry: Our experience in a developing country. Noise and Health, 2012, 14(57):68.
[17] LEGHARI S.K., ZAIDI M.A., SIDDIQUI M.F., SARANGZAI A.M., SHEIKH S.U., and ARSALAN, Dust exposure risk from stone crushing to workers and locally grown plants species in Quetta, Pakistan. Environmental monitoring and assessment, 2019, 191(12):740.
[18] KHAN M.M., NAWAZ R., EHSAN N., AHMAD S.,NAWAZ M.W., and NAWAZ M.H., Health Hazards and Socioeconomic Effects of Stone Crushing Industry on Its Workers : A Case Study of Sargodha , Pakistan. Journal of Environmental and Agricultural Sciences, 2016.6, 40–46.
[19].AMMAR KALAS M., CHAVEZ L., LEON M., TASWEESEDT P.T., and SURANI S., Abnormal Liver Enzymes: A review for Clinicians. World Journal of Hepatology, 2021, 13(11):1688-1689.
[20] HIMMERICH H., ANGHELESCU I., KLAWE C., C and SZEGEDI A., Vitamin B12 and Hepatic enzyme levels correlate in male alcohol dependent patients. Alcohol & Alcoholism, 2001, 36: 26-28.
[21] ALFADALY N., ABOUL-HAGAG K.E., AL-ROBAEE A., AL SHOBAILI H., and AZOLIBAN A., Toxicological Study on the Health Effects of Long Term Exposure To Benzene in Benzene Filling Workers, Qassim Region, Ksa. The Egyptian Journal of Forensic Sciences and Applied Toxicology, 2016, 16(1):81-94.
[22] YATULAINI F., TUALEKA A.R., JALALUDIN J., and RUSSENG S.S., The Relationship between Duration of Benzene Exposure with Liver Enzymes in Car Painting Workshop Workers Hubungan antara Durasi Paparan Benzena dengan Enzim Hati pada Pekerja Pengecatan Mobil. The Indonesian Journal of Occupational Safety and Health, 2021, 10(3):361-70.
[23] ABDEL-RASOUL G.M., SALEM E.A., HENDY O.M., ROHLMAN D., ABDEL LATIF A.A., and ELBADRY A.S., Respiratory, hepatic, renal, and hematological disorders among adolescent females environmentally exposed to pesticides, Menoufia governorate, Egypt. Environmental Science and Pollution Research, 2022, 29(25):37804-14.
[24] M ARUNSI O., I IKARAOHA C., U NWANJO H., Evaluation of Some Kidney and Liver Function Markers in Humans Exposed to Pesticides in Okagwe and Ihe-Nta, Abia State, Nigeria. International Journal of Nanotechnology Research, 2022, 5.
[25] IQBAL M.I., FERNANDO, A., and SOEMARKO, D., Short-term occupational hazard exposure at tire mechanic workshops can aggravate hepatic cirrhosis? A case report. International Journal of Health, Education & Social, 2021, 4(1):22-31.
[26] NUNES DE PAIVA M.J., PEREIRA BASTOS DE SIQUEIRA M.E., Increased serum bile acids as a possible biomarker of hepatotoxicity in Brazilian workers exposed to solvents in car repainting shops. Biomarkers, 2005; 10(6):456-63.
[27] RABIEE M., and RAZAVIAN S.M., Evaluation of liver biochemical parameters in manganese miners. Zahedan Journal of Research in Medical Sciences, 2014, 16(6).
[28] FESTUS O.O., AGBEBAKU S.O., IDONIJE B.O., and OLUBA O.M,. Influence of Cement Dust Exposure on Indicators of Hepatic Function in Male Cement Handlers in Ekpoma, Nigeria. Electronic Journal of Medical and Educational Technologies, 2021,14(2).
[29] ZAWILLA N., TAHA F., IBRAHIM Y., Liver functions in silica-exposed workers in Egypt: possible role of matrix remodeling and immunological factors. International Journal of Occupational and environmental health, 2014, 20(2):146-56.
[30] YAQOOB M., BELL G.M., STEVENSON A., MASON H., PERCY D.F. Renal impairment with chronic hydrocarbon exposure. QJM: An International Journal of Medicine, 1993, 86, 3:165–174.
[31] MANDAL A., and PAUL S. Liver enzyme status and cardiovascular parameters of construction workers from West Bengal, India. Journal of Human Ergology, 2016, 2, 45(2):33-47.
[32] SANTAMARIA A.B., Manganese exposure, essentiality & toxicity. Indian Journal of Medical Research, 2008, 128, (4): 484–500.
[33] GE X., LIU Z., HOU Q., HUANG L., ZHOU Y., LI D., HUANG S., LUO X., LV Y., LI L., and Cheng H., Plasma metals and serum bilirubin levels in workers from manganese-exposed workers healthy cohort (MEWHC). Environmental Pollution, 2020, 258:113683.
[34] NWIBO A. N., UGWUJA E.I., NWAMBEKE N.O., EMELUMADU O.F., and OGBONNAYA L.U., Pulmonary problems among quarry workers of stone crushing industrial site at Umuoghara, Ebonyi State, Nigeria. International Journal of Occupational and Environmental Medicine, 2012, 3 (4):178–85.

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