CLINICO-BIOCHEMICAL STUDY USING DIFFERENT SUTURE MATERIALS AND ANESTHETIC COMBINATIONS DURING PERFORMING HERNIORRHAPHY IN CALVES

Main Article Content

Sohaib Safdar
Sadaf Aslam
Ali Qaisar
Abdul Aziz
Areesha Arkan
Sania Arif Dar
Syed Mohsin Abbas
Obaid Muhammad Abdullah

Keywords

Livestock Production, Calf Herniorrhaphy, Surgical Stress, Anesthetic Agents, Suture Material Selection

Abstract

The agricultural sector of Pakistan is economically dependent on livestock production, which makes a substantial contribution to the agricultural domain. Agriculture accounts for 11% of the gross domestic product (GDP), with livestock contributing a significant 56.3% to the agricultural GDP. With a specific emphasis on calf herniorrhaphy, this research highlights the importance of livestock and a considerable threat it poses to the livestock industry. This study investigates the various forms and etiology of hernias in calves, with a particular focus on the high incidence of congenital hernias and the contributing factors that facilitate their development. The physiological reaction to surgical procedures is also investigated, with particular emphasis on the stress response. Compensatory surgical stress has the potential to result in extended recovery periods and heightened morbidity. The study underscores the criticality of reducing surgical tension in order to facilitate a speedier recovery following the procedure. In addition, the paper examines the effects of various anesthetic agents on physiological parameters and stress indicators, focusing on the combined effects of propofol and ketamine. Suture material selection is a critical factor in determining the efficacy of calf herniorrhaphy procedures. Chromatomal cat gut and polyglactin 910, two frequently employed suture materials, are compared in this study with respect to digestion, strength of tensile, and tissue reaction.


The selection of suture material is critical in terms of attaining the precision and accuracy that surgeons seek during surgical procedures.The objective of this study is to address a knowledge gap in the current body of research by examining the stress levels experienced by calves undergoing umbilical hernia surgery under various types of general anesthesia (propofol and ketamine), as per cortisol levels. Additionally, a comparative analysis is performed in the study between suture materials composed of polyglactin 910 and chromic catgut. The results obtained from this investigation provide significant contributions to the understanding of how to optimize surgical procedures and improve outcomes following calf herniorrhaphy.

Abstract 224 | Pdf Downloads 84

References

1. Aderriotis D, Sàndor GK. 1999. Outcomes of irradiated polyglactin 910 Vicryl Rapide fast-absorbing suture in oral and scalp wounds. J Can Dent Assoc. 65: 345-347.
2. Adetunji A, Ajadi R. 2002. Repeat bolus versus continues propofol infusion technique. J Israel Veterinary Med Associ. 57(4): 35-50.
3. Afzal M. 2008. Corporate dairy farming in Pakistan-Is there a future. Pak J Agri Sci. 45(2).
4. Anandmay A, Dass L, Sharma A, Gupta M, Singh K, Roy B. 2016. Clinico-anesthetic changes following administration of propofol alone and in combination of meperidine and pentazocine lactate in dogs. Vet world. 9(11): 1178.
5. Anis N, Berry S, Burton N, Lodge D. 1983. The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br J Pharmacol. 79(2): 565.
6. Aslam S, Akhtar R, Khan MA, Akbar H, Masood S, Fareed U, Nasir S, Ahmed SF, Ahmed SS, Saeed S. Clinico-biochemical study on different pre-anesthetic drugs combined with propofol for neutering dogs.
7. Bates RO, Straw B. 2008. Hernias in growing pigs. Michigan state university pork quarterly. 13: 1-4.
8. Bednarski R, Grimm K, Harvey R, Lukasik VM, Penn WS, Sargent B, Spelts K. 2011. AAHA anesthesia guidelines for dogs and cats. J Am Anim Hosp Assoc. 47(6): 377-385.
9. Beteg F, Muste A, Mates N, Donisa A, Scurtu L, Bota A, Krupaci A. 2010. Observation concerning the effects of medetomidine-microdose on diazepamketamine induced anaesthesia in dogs. Lucrari Sfiinfifice-Universitatea de Sfiinte Agricole a Banatului Timisoara, Medicina Veterinara. 43(10): 95-99.
10. Blomstedt B, Jacobsson S. 1977. Experiences with polyglactin 910 (Vicryl) in general surgery. Acta Chir Scand. 143(5): 259.
11. Bodh D. 2011. Evaluation of propofol and isofluorane for general anaesthesia under midazolam butorphanol premedication in bovine. Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana.
12. Cassu RN, Luna SP, Clark RM, Kronka SN. 2008. Electroacupuncture analgesia in dogs: is there a difference between uni-and bi-lateral stimulation? Vet Anaesth Analg. 35(1): 52-61.
13. Celestine Okwudili U, Athanasius Chinedu E, Jonas Anayo O. 2014. Biochemical effects of xylazine, propofol, and ketamine in West African dwarf goats. J Vet Med. 2014.
14. Chandio AA, Yuansheng J, Rahman T, Khan MN, Guangshun X, Zhi Z. 2015. Analysis of agricultural subsectors contribution growth rate in the agriculture GDP growth rate of Pakistan. Int J Humanit Soc Sci Invent. 4(8): 101-105.
15. Church D, Nicholson A, Ilkiw J, Emslie D. 1994. Effect of non-adrenal illness, anaesthesia and surgery on plasma cortisol concentrations in dogs. Res Vet Sci. 56(1): 129-131.
16. Coggins M, Rosenzweig A. 2012. The fire within: cardiac inflammatory signaling in health and disease.
17. Circ Res. 110(1): 116-125.
18. CorsseB G, Domino E. 1966. Dissociative anesthesia: further pharmacological studies and first clinical experience with the phencyclidine derivative CI-581. Anesth Analg.(Cleve.). 45: 29.
19. Craig P, Williams J, Davis K, Magoun A, Levy A, Bogdansky S, Jones Jr J. 1975. A biologic comparison of polyglactin 910 and polyglycolic acid synthetic absorbable sutures. Surg Gynecol Obste. 141(1): 1-10.
20. Dad Brohi R, Kalhoro AB, Kachiwal AB, Kalhoro IB, Kalhoro DH, Ahmed S, Khan FA, Talpur HS, Bhattaria D. 2019. Comparative Effect of Propofol and Thiopentone Sodium in Sheep Sedated with Xylazine Hydrochloride. Pak J Zool. 51(1).
21. de Mattos Junior E, dos Santos GJvG, Russo C, Saut JPE, Headley SA. 2009. Evaluation of cortisol and glycemia levels of dogs anesthetized with sevoflurane and premedicated with either butorphanol or phetidine. Semina: Cienc Agra. 30(2): 425-434.
22. DEMİRKAN İ, Atalan G, GÖKCE Hİ, ÖZAYDIN İ, ÇELEBİ F. 2002. Comparative study of butorphanol-ketamin HCl and xylazine-ketamin HCl combinations for their clinical and cardiovascular/respiratory effects in healthy dogs. Turk J Vet Anim Sci. 26(5): 1073-1079.
23. Dewangan R, Tiwari S, Sharda R, Kalim M. 2016. Haemato-biochemical response to xylazine-propofol anaesthesia in dogs. Int J Sci Environ Technol. 5(4): 2331-2336.

24. Dimitrov D, Aminkov K, Marinov G. Influence of different anesthetics on some physiological parameters and stress markers during and after surgery of a dog.
25. Dobson GP. 2015. Addressing the global burden of trauma in major surgery. Front Surg. 2: 43.
26. Dragoo JL, Braun HJ, Durham JL, Ridley BA, Odegaard JI, Luong R, Arnoczky SP. 2012. Comparison of the acute inflammatory response of two commercial platelet-rich plasma systems in healthy rabbit tendons. Am J Sports Med. 40(6): 1274-1281.
27. Eichner R, Prior R, Kvasnicka W. 1979. Xylazine-induced hyperglycemia in beef cattle. Am J Vet Res.
28. 40(1): 127.
29. Fathy M. 2018. Estimate the effect of propofol and ketamine on clinical and hematological parameters in xylazine pre-meditated baladi Egyptian Donkeys. Vet Sci Res Rev. 4(2): 35-42.
30. Ferreira JP, Brighton Dzikiti T, Zeiler GE, Buck R, Nevill B, Gummow B, Bester L. 2015. Anaesthetic induction and recovery characteristics of a diazepam-ketamine combination compared with propofol in dogs. J S Afr Vet Assoc. 86(1): 01-07.
31. Frias AF, Mársico F, de Segura IAG, Nascimento Jr PR, Nascimento A, Soares JH, Almosny NR. 2003. Evaluation of different doses of propofol in xylazine pre–medicated horses. Vet Anaesth Analg. 30(4): 193-201.
32. Gaynor JS, Muir WW. 2014. Handbook of Veterinary Pain Management-E-Book. Elsevier Health Sciences.
33. Gehring R, Coetzee J, Tarus‐Sang J, Apley M. 2009. Pharmacokinetics of ketamine and its metabolite norketamine administered at a sub‐anesthetic dose together with xylazine to calves prior to castration. J Vet Pharmacol Ther. 32(2): 124-128.
34. Genccelep M, Aslan L, Sahin A, Sindak N. 2005. Effect of propofol anaesthesia in calves. Indian Vet.
35. 82(5): 516-518.
36. GH R, MM S, M Halfaya F. 2017. Comparison of quality of anesthetic effect between intramuscularly administered ketamine, intravenously administered ketamine and intravenously administered propofol in diazepam premedicated goats. J Vet Med Res. 24(2): 247-256.
37. Glowaski MM, Wetmore LA. 1999. Propofol: application in veterinary sedation and anesthesia. Clin Tech Small Anim Pract. 14(1): 1-9.
38. Greenwald D, Shumway S, Albear P, Gottlieb L. 1994. Mechanical comparison of 10 suture materials before and after in vivo incubation. J Surg Res. 56(4): 372-377.
39. Gross ME, Dodam JR, Pope ER, Jones BD. 2002. A comparison of thiopental, propofol, and diazepam- ketamine anesthesia for evaluation of laryngeal function in dogs premedicated with butorphanol- glycopyrrolate. J Am Anim Hosp Assoc. 38(6): 503-506.
40. Gweba M, Onifade K, Faleke O. 2010. Effect of xylazine sedation on some clinico-physiological and haematological parameters in Sokoto red goats. Niger Vet J. 31(2).
41. Hassen D, Kawo H, Gondore M. 2017. A Preliminary Study on Hernia in Domestic Animals in Gondar Town, North Gondar, North West Ethiopia. J Vet Sci Technol. 8: 420-427.
42. Hellebrekers LJ, de Boer E-JW, van Zuylen MA, Vosmeer H. 1997. A comparison between medetomidine-ketamine and medetomidine-propofol anaesthesia in rabbits. Lab Anim. 31(1): 58- 69.
43. Herrmann JB, Kelly RJ, Higgins GA. 1970. Polyglycolic acid sutures: laboratory and clinical evaluation of a new absorbable suture material. Arch Surg. 100(4): 486-490.
44. Hobbs B, Rolhall T, Sprenkel T, Anthony K. 1991. Comparison of several combinations for anesthesia in rabbits. Am J Vet Res. 52(5): 669.
45. Hodgkinson O, Dawson L. 2007. Practical anaesthesia and analgesia in sheep, goats and calves. In Pract.
46. 29(10): 596-603.
47. Hofmeister EH, Williams CO, Braun C, Moore PA. 2008. Propofol versus thiopental: effects on peri- induction intraocular pressures in normal dogs. Vet Anaesth Analg. 35(4): 275-281.
48. Hug JC, McLeskey C, Nahrwold M, Roizen M, Stanley T, Thisted R, Walawander C, White P, Apfelbaum J, Grasela T. 1993. Hemodynamic effects of propofol: data from over 25,000 patients. Anesth Analg. 77(4 Suppl): S21-29.
49. Ivanovs I, Mihelsons M, Boka V editors. Proceedings of the Latvian Academy of Sciences. Sci B Nat
50. Exact Appl Sci.; 2012.
51. Jena B, Das J, Nath I, Sardar KK, Sahoo A, Beura SS, Painuli A. 2014. Clinical evaluation of total

52. intravenous anaesthesia using xylazine or dexmedetomidine with propofol in surgical management of canine patients. Vet World. 7(9).
53. Ježek J, Klopčič M, Klinkon M. 2006. Influence of age on biochemical parameters in calves. Bull Vet Inst Pulawy. 50: 211-214.
54. Ji-wan K, In-ho J. 1999. The Effects of Xylazine Premedication on the Propofol Anesthesia in the Dog.
55. Korean J Vet Clin Med. 16(1): 86-94.
56. Kanaya N, Hirata N, Kurosawa S, Nakayama M, Namiki A. 2003. Differential effects of propofol and sevoflurane on heart rate variability. Anesthesiology: The Journal of the American Society of Anesthesiologists. 98(1): 34-40.
57. KEEGAN RD, GREENE SA. 1993. Cardiovascular Effects of a Continuous Two‐Hour Propofol Infusion in Dogs Comparison With Isoflurane Anesthesia. Vet Surg. 22(6): 537-543.
58. Kilic N. 2008. Cardiopulmonary, biochemical and haematological changes after detomidine-midazolam- ketamine anaesthesia in calves. Bull Vet Inst Pulawy. 52(3): 453-456.
59. Kinjavdekar P, Aithal H, Pawde A, Pathak M, Borena B, Malik V. 2010. Physiological and biochemical effects of medetomidine-butorphanolpropofol anaesthesia in dogs undergoing orthopaedic surgery. Indian J Vet Surg. 31(2): 101-104.
60. Kinjavdekar P, Singh G, Aithal H, Pawde A. 2007. Clinicophysiological effects of spinally administered ketamine and its combination with xylazine and medetomidine in healthy goats. Vet Res Commun. 31(7): 847-861.
61. Ko J, Thurmon J, Tranquilli W, Benson G, Olson W. 1992. A comparison of medetomidine-propofol and medetomidine-midazolam-propofol anesthesia in rabbits. Lab Anim Sci. 42(5): 503-507.
62. Ko JC, Mandsager RE, Lange DN, Fox SM. 2000. Cardiorespiratory responses and plasma cortisol concentrations in dogs treated with medetomidine before undergoing ovariohysterectomy. J Am Vet Med Assoc. 217(4): 509-514.
63. Kobayashi T. 2009. Long-term results of stereotactic gamma knife radiosurgery for pituitary adenomas.
64. In. Japanese Experience with Gamma Knife Radiosurgery. Karger Publishers. p. 77-95.
65. Koichev K, Golemanov D, Houbenov H, Aminkov B. 1988. Experimental Study On The Effect of “Domosedan” in Sheep and Cattle. J Assoc Vet Anaesthetists of Great Britain and Ireland. 15(1): 114-126.
66. Kumar D, Kumar S. 2015. Acquired ventral abdominal hernia in a male giraffe calf. Indian J Vet Pathol.
67. 39(1): 102-103.
68. Lerche P, Reid J, Nolan A. 2000. Comparative study of propofol or propofol and ketamine for the induction of anaesthesia in dogs. Vet Rec. 146(20): 571-574.
69. Maan MK, Khan MA, Bokhari SG, Ijaz M, Akbar H, Umar S, Sohail ML. 2018. Clinico-biochemical Effects of xylazine-ketamine and isoflurane on rabbits undergoing ovariohysterectomy. Pak J Zool. 50(2).
70. Mair AR, Pawson P, Courcier E, Flaherty D. 2009. A comparison of the effects of two different doses of ketamine used for co-induction of anaesthesia with a target-controlled infusion of propofol in dogs. Vet Anaesth Analg. 36(6): 532-538.
71. Manat DL. Studies on anaesthetic evaluation of propofol-thiopentone sodium as an induction and maintenance agent in dogs (Canis domestica). AAU, Anand.
72. Maney JK, Shepard MK, Braun C, Cremer J, Hofmeister EH. 2013. A comparison of cardiopulmonary and anesthetic effects of an induction dose of alfaxalone or propofol in dogs. Vet Anaesth analg. 40(3): 237-244.
73. McKeirnan KL, Gross ME, Rochat M, Payton M. 2014. Comparison of propofol and propofol/ketamine anesthesia for evaluation of laryngeal function in healthy dogs. J Am Anim Hosp Assoc. 50(1): 19-26.
74. Mion G, Villevieille T. 2013. Ketamine pharmacology: an update (pharmacodynamics and molecular aspects, recent findings). CNS Neurosci Ther. 19(6): 370-380.
75. Monsang WS, Baishya MP, Kumar M, Roy J, Pal SK. 2014. A Rare Case of Umbilical Hernia in a Chinchilla Rabbit (Oryctolagus cuniculus): Its Surgical Management. J Adv Vet Res. 4(3): 149- 151.
76. Mook D. 2006. Anesthetic management of rodents and rabbits. In.
77. Mottelib A, El‐Gindi M. 1975. Studies on Buffaloes Tranquillized by Rompum‐“Bayer”. Zentralbl

78. Veterinarmed A. 22(5): 407-413.
79. Naddaf H, Varzi HN, Sabiza S, Falah H. 2014. Effects of xylazine-ketamine anesthesia on plasma levels of cortisol and vital signs during laparotomy in dogs. Open Vet J. 4(2): 85-89.
80. Pai A, Heining M. 2007. Ketamine. Continuing Education in Anaesthesia, Critical Care & Pain. 7(2): 59- 63.
81. Psatha E, Alibhai HI, Jimenez-Lozano A, Armitage-Chan E, Brodbelt DC. 2011. Clinical efficacy and cardiorespiratory effects of alfaxalone, or diazepam/fentanyl for induction of anaesthesia in dogs that are a poor anaesthetic risk. Vet Anaesth Analg. 38(1): 24-36.
82. Pypendop BH, Ilkiw JE. 2005. The effects of intravenous lidocaine administration on the minimum alveolar concentration of isoflurane in cats. Anesth Analg. 100(1): 97-101.
83. Rehman A, Jingdong L, Chandio AA, Hussain I. 2017. Livestock production and population census in Pakistan: Determining their relationship with agricultural GDP using econometric analysis. Inf Process Agric. 4(2): 168-177.
84. Restitutti F, Raekallio M, Vainionpää M, Kuusela E, Vainio O. 2012. Plasma glucose, insulin, free fatty acids, lactate and cortisol concentrations in dexmedetomidine-sedated dogs with or without MK- 467: a peripheral α-2 adrenoceptor antagonist. Vet J. 193(2): 481-485.
85. Robertson S, Johnston S, Beemsterboer J. 1992. Cardiopulmonary, anesthetic, and postanesthetic effects of intravenous infusions of propofol in greyhounds and non-greyhounds. Am J Vet Res. 53(6): 1027-1032.
86. Robinson R, Borer–Weir K. 2013. A dose titration study into the effects of diazepam or midazolam on the propofol dose requirements for induction of general anaesthesia in client owned dogs, premedicated with methadone and acepromazine. Vet Anaesth Analg. 40(5): 455-463.
87. Saidu AM, Bokko PB, Mohammed A, Bukbuk DN, Igwenagu E. 2016. Serum cortisol of Sahel goats following rumenotomy with assorted anaesthetics and sutures. Int J Vet Sci Med. 4(1): 23-26.
88. Sainsbury J, Stoddart J, Watson M. 1981. Plasma cortisol levels: a comparison between sick patients and volunteers given intravenous cortisol. Anaesth. 36(1): 16-21.
89. Sarrafzadeh-Rezaei F, Rezazadeh F, Behfar M. 2007. Comparison of caudal epidural administration of lidocaine and xylazine to xylazine/ketamine combination in donkey (Equus asinus). Iran J Vet Surg. 2(5): 7-16.
90. Short CE, Bufalari A. 1999. Propofol anesthesia. Vet Clin North Am Small Anim Pract. 29(3): 747-778. Singh GD, Kinjavdekar P, Aithal HP, Pawde AM, Zama M, Singh J, Tiwary R. 2013. Clinicophysiological and haemodynamic effects of fentanyl with xylazine, medetomidine and dexmedetomidine in isoflurane-anaesthetised water buffaloes (Bubalus bubalis). J S Afr Vet
91. Assoc. 84(1): 1-11.
92. Singh P, Pratap K, Kinjavdekar P, Aithal H, Singh G. 2005. Effects of xylazine, lignocaine and their combination for lumbar epidural analgesia in water buffalo calves (Bubalus bubalis). J S Afr Vet Assoc 76(3): 151-158.
93. Sjaastad OV, Hove K, Sand O. 2010. Physiology of domestic animals. Scan Vet Press. Slatter DH. 2003. Textbook of small animal surgery.
94. Slingsby L, Waterman-Pearson A. 2000. The post-operative analgesic effects of ketamine after canine ovariohysterectomy—a comparison between pre-or post-operative administration. Res Vet Sci. 69(2): 147-152.
95. Soliman M, El Amrousi S, Khamis M. 1965. The influence of tranquillisers and barbiturate anaesthesia on the blood picture and electrolytes of dogs. Vet Rec. 77(43): 1256.
96. Struys M, Vanpeteghem C, Huiku M, Uutela K, Blyaert N, Mortier E. 2007. Changes in a surgical stress index in response to standardized pain stimuli during propofol–remifentanil infusion. Br J Anaesth. 99(3): 359-367.
97. Suarez MA, Dzikiti BT, Stegmann FG, Hartman M. 2012. Comparison of alfaxalone and propofol administered as total intravenous anaesthesia for ovariohysterectomy in dogs. Vet Anaesth Analg. 39(3): 236-244.
98. Sutradhar BC, Hossain MF, Das BC, Kim G, Hossain MA. 2009. Comparison between open and closed methods of herniorrhaphy in calves affected with umbilical hernia. J Vet Sci. 10(4): 343-347.
99. Thaller SR. 2014. Grabb and Smith’s plastic surgery. Plast Reconstr Surg. 133(5): 1311-1312.
100. Tiwari S, Chonde M, Shinkar D, Gawande P. 2004. Surgical repair of ventral hernia in cattle: A report of

101. six cases. Indian Vet J. 81(6): 695-696.
102. Tramer M, Moore R, McQuay H. 1997. Propofol and bradycardia: causation, frequency and severity. Br J Anaesth. 78(6): 642-651.
103. Umar M, Adam M. 2013. Effects of combination of ketamine-medetomidine anaesthesia on haematology and some serum chemistry parameters in dogs. Niger Vet J. 34(3).
104. VanNatta ME, Rex DK. 2006. Propofol Alone Titrated to Deep Sedation Versus Propofol in Combination with Opioids and/or Benzodiazepines and Titrated to Moderate Sedation for Colonoscopy: CME. Am J Gastroenterol. 101(10): 2209-2217.
105. Venugopalan A. 2000. Paravertebral Nerve Block In Bovine. Essentials of Veterinary Surgery. 8th Ed., Oxford & IBH Publishing Co. PVT. LTD, New Delhi, India. pp. 483-484.
106. Von Fraunhofer J, Storey R, Stone I, Masterson B. 1985. Tensile strength of suture materials. J Biomed Mater Res. 19(5): 595-600.
107. White KL, Shelton K, Taylor PM. 2001. Comparison of diazepam–ketamine and thiopentone for induction of anaesthesia in healthy dogs. Vet Anaesth Analg. 28(1): 42-48.
108. Wyatt J, Scott R, Richardson M. 1989. The effects of prolonged ketamine-xylazine intravenous infusion on arterial blood pH, blood gases, mean arterial blood pressure, heart and respiratory rates, rectal temperature and reflexes in the rabbit. Lab Anim Sci. 39(5): 411-416.
109. Yaltirik M, Dedeoglu K, Bilgic B, Koray M, Ersev H, Issever H, Dulger O, Soley S. 2003. Comparison of four different suture materials in soft tissues of rats. Oral Dis. 9(6): 284-286.
110. Zoran D, Riedesel D, Dyer D. 1993. Pharmacokinetics of propofol in mixed-breed dogs and greyhounds. Am J Vet Res. 54(5): 755-760.

Most read articles by the same author(s)