DETERMINE THE PREVALENCE OF CANDIDA ISOLATES FROM URINE OF PATIENTS

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Rameez Ahmed Mughal
Yassar Hussain Patujo
Qazi Adil Inam
Muhammad Abbas
Sami Ullah
Nusrum Iqbal

Keywords

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Abstract

Introduction:The prevalence of candiduria, the presence of Candida in urine, has been increasingly perceived in hospitalized patients, particularly those with underlying conditions such as immunosuppression, urinary tract abnormalities, or delayed antibiotic use.


Objectives: The main objective of the study is to find the prevalence of candida isolates from urine of patients.


Methodology of the study: This prospective observational study was conducted at Benazir Bhutto Hospital, Rawalpindi from March 2023 to September 2023. Data were collected from 320 patients who underwent urine culture for clinical indications such as suspected urinary tract infection or routine surveillance. Data were collected through a designed performa which contain all the information related to patients. Urine samples were collected and processed for Candida identification using standard microbiological techniques, including culture, colony morphology assessment, and biochemical tests.


Results: Data were collected from 320 patients suffering from UTI. Mean age of the patients was 55.09±10.5 years. There were 176 (55%) male and 144 (45%) female patients. DM was most common 128 (40%) and after that hypertension 112(35%) most common comorbidity in patients. Candida albicans is the most prevalent species, comprising 60% of candiduria cases, followed by Candida glabrata (20%) and Candida tropicalis (10%). Antifungal susceptibility testing revealed high susceptibility rates to commonly used agents, with fluconazole exhibiting 85% efficacy, amphotericin B 90%, and echinocandins demonstrating susceptibility exceeding 95%.


Conclusion: It is concluded that candiduria represents a significant concern among hospitalized patients, with Candida albicans predominating as the causative species. Antifungal susceptibility testing indicates favorable profiles for commonly used agents such as fluconazole, amphotericin B, and echinocandins.

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