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Jeet Patel
Ms. Krupa Vyas
Dr. Pragnesh Patani


dermatophytes, antifungal activity, fungitoxicity, herbs[medicinal plants]


- millions of people each year are affected by dermatophytes, which are the most frequent cause of fungal infections worldwide. The emergence of resistance among dermatophytes and the availability of antifungal susceptibility tests appropriate for testing antifungal agents against this group of fungi make the combinatorial approach particularly interesting to be investigated. As a result, we examined the scientific literature on antifungal combinations that are effective against dermatophytes. A pubmed search of the relevant literature produced 68 publications: 37 articles mentioning in vitro studies and 31 articles mentioning case reports or clinical studies. More than 400 clinical isolates of dermatophytes (mostly trichophyton spp., microsporum spp., and 2% epidermophyton floccosum) were used in in vitro studies. Combinations included two antifungal substances or an antifungal substance plus a second chemical substance, such as plant extracts

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