“A COMPREHENSIVE REVIEW OF BOTANICAL INGREDIENTS LIKE PUMPKIN SEEDS, BLACK CUMIN SEEDS AND BURDOCK ROOTS AND THEIR EFFICACY FOR HEALTHY HAIR AND PREVENTING PREMATURE GRAYING OF HAIRS.”
Main Article Content
Keywords
Hair Health, Pumpkin seeds, Black cumin seeds and Burdock roots
Abstract
Hair health and the prevention of premature graying have been enduring concerns for individuals seeking natural and effective remedies. Hair is a crucial aspect of an individual's appearance, enhancing their personality, glamour, self-esteem, and confidence. It is a protein filament that grows from dermal follicles and is derived from the skin's ectoderm. Hair growth and pigmentation are biological activities of hair follicles, and it is essential to care for both the hair follicle and the hair shaft for healthy, manageable hair. Micronutrients, such as vitamins and minerals, play essential roles in maintaining hair health and growth. Hair follicles undergo four stages: anagen (growth stage), catagen (degenerative phase), telogen (resting stage), and exogen (shedding stage). Pumpkin seeds, known for their rich nutrient profile, contain vitamins, minerals, and antioxidants that are crucial for hair health. Their potential to strengthen hair follicles, improve hair texture, and reduce hair loss will be explored in this review. Black cumin seeds, a source of essential fatty acids, vitamins, and minerals, have gained attention for their purported ability to combat hair loss, promote hair growth, and maintain natural hair color. Burdock roots, traditionally used for their detoxifying properties, are also recognized for their role in nourishing the scalp and supporting overall hair health
References
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15. Farhan N, Salih N, Salimon J. A REVIEW ON OLIVE OIL AND Nigella sativa L. BLACK CUMIN SEED OIL: COMPOSITION AND BIOLOGICAL ACTIVITY. Rasayan Journal of Chemistry. 2021 Oct 1;14(4).
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17. Hajhashemi V, Rajabi P, Mardani M. Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model. Avicenna journal of phytomedicine. 2019 Nov;9(6):499.
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23. Ibrahim IM, Hasan MS, Elsabaa KI, Elsaie ML. Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: A randomized comparative trial. Journal of Cosmetic Dermatology. 2021 Sep;20(9):2867-73.
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25. Lestari B, Meiyanto E. A review: the emerging nutraceutical potential of pumpkin seeds. Indonesian Journal of Cancer Chemoprevention. 2018 Jul 3;9(2):92-101.
26. Lim TK. Edible medicinal and non-medicinal plants. Dordrecht, The Netherlands:: Springer; 2012.
27. Lindner G, Botchkarev VA, Botchkareva NV, Ling G, van der Veen C, Paus R. Analysis of apoptosis during hair follicle regression (catagen). The American journal of pathology. 1997 Dec;151(6):1601.
28. Matsui T, Guth H, Grosch W. A comparative study of potent odorants in peanut, hazelnut, and pumpkin seed oils on the basis of aroma extract dilution analysis (AEDA) and gas chromatography‐olfactometry of headspace samples (GCOH). Lipid/Fett. 1998 Feb;100(2):51-6.
29. Meenakshisundaram A, Harikrishnan TJ, Anna T. Anthelmintic evaluation of Cucurbita pepo against gastrointestinal nematodes of sheep. Indian Journal of Animal Research. 2017;51(3):518-24.
30. Milner Y, Kashgarian M, Sudnik J, Filippi M, Kizoulis M, Stenn K. Exogen, shedding phase of the hair growth cycle: characterization of a mouse model. Journal of Investigative Dermatology. 2002 Sep 1;119(3):639-44.
31. Mir SA, Dar LA, Ali T, Kareem O, Rashid R, Khan NA, Chashoo IA, Bader GN. Arctium lappa: A review on its phytochemistry and pharmacology. Edible Plants in Health and Diseases: Volume II: Phytochemical and Pharmacological Properties. 2022 Mar 15:327-48.
32. Moraru DI, Ploscutanu G, Stoica M. Health benefits of edible round-fruited types of Cucurbita pepo-a short review. Journal of Agroalimentary Processes and Technologies. 2018;24(3):202-6.
33. Müller-Röver S, Foitzik K, Paus R, Handjiski B, van der Veen C, Eichmüller S, McKay IA, Stenn KS. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. Journal of investigative dermatology. 2001 Jul 1;117(1):3-15.
34. ONAR HÇ, Hasniye YA. New Natural Inventions Against Hair Loss (Alopecia). PIONEER AND CONTEMPORARY STUDIES IN NATURAL SCIENCE AND MATHEMATICS. 2023 Jul 17:41-58.
35. Patel S, Sharma V, S Chauhan N, Thakur M, Dixit VK. Hair growth: focus on herbal therapeutic agent. Current drug discovery technologies. 2015 Mar 1;12(1):21-42.
36. Paulsen E. Contact sensitization from Compositae‐containing herbal remedies and cosmetics. Contact Dermatitis. 2002 Oct;47(4):189-98.
37. Paus R, Cotsarelis G. The biology of hair follicles. New England journal of medicine. 1999 Aug 12;341(7):491-7.
38. Penkar GM, Salkar MR, Chavan PS, Ambade MS, Parab SA, Padte TS, Salgoankar PL, Sawant MM, Jagtap VA. An Overview on Indian Herbs in Hair Care Therapy. Research Journal of Pharmacognosy and Phytochemistry. 2023 Apr 1;15(2):161-6.
39. Rajsekhar S, Kuldeep B. Pharmacognosy and pharmacology of Nigella sativa-A review. International Research Journal of Pharmacy. 2011;2(11):36-9.
40. Randall VA, Botchkareva NV. The biology of hair growth. Cosmetics Applications of Laser & Light-Based Systems. 2009 Jan 1:3-5.
41. Ratnam N, Naijibullah M, Ibrahim MD. A review on Cucurbita pepo. Int J Pharm Phytochem Res. 2017;9:1190-4.
42. Rifat-Uz-Zaman MS, Khan MS. Gastroprotective and anti-secretory effect of Nigella sativa seed and its extracts in indomethacin-treated rats. Pak J Biol Sci. 2004;7:995-1000.
43. Ruwanthika KH, Munasinghe MM, Marapana RU. Overview of Cucurbita spp.(pumpkin) and development of value-added products emphasizing its nutritional and chemical composition. World Journal of Advanced Research and Reviews. 2023;18(2):1215-26.
44. Salama M, Salama SG. Arctium lappa L.(Asteraceae); a new invasive highly specific medicinal plant growing in Egypt. Pyrex Journal of Plant and Agricultural Research. 2016.
45. Saraf S, Jharaniya M, Gupta A, Jain V, Saraf S. Herbal hair cosmetics: advancements and recent findings. World J Pharm Res. 2014 Jan 8;3(2):3278-94.
46. Satheeshan KN, Seema BR, Manjusha AM. Development and evaluation of VCO based herbal hair tonic. Journal of Pharmacognosy and Phytochemistry. 2020;9(3):485-93.
47. Sayyad TR, Chaudhari SS, Nikumbh PP, Bhurat MR. EVALUATION, COMPOSITION AND COMPARATIVE STUDY OF HAIR GROWING TONIC, Pharmaceutical Resonance 2023 Vol. VI - Issue I.
48. Schneider MR, Schmidt-Ullrich R, Paus R. The hair follicle as a dynamic miniorgan. Current biology. 2009 Feb 10;19(3):R132-42.
49. Semalty M, Semalty A, Joshi GP, Rawat MS. Hair growth and rejuvenation: an overview. Journal of dermatological treatment. 2011 Jun 1;22(3):123-32.
50. Shafiq H, Ahmad A, Masud T, Kaleem M. Cardio-protective and anti-cancer therapeutic potential of Nigella sativa. Iranian journal of basic medical sciences. 2014 Dec;17(12):967.
51. Shergill-Bonner R. Micronutrients. Paediatrics and Child Health. 2017 Aug 1;27(8):357-62.
52. Thakur S, Kaurav H, Chaudhary G. Nigella sativa (Kalonji): A black seed of miracle. International Journal of Research and Review. 2021;8(4):342-57.
53. Tkacheva N, Eliseeva T. Burdock (lat. Árctium). Journal of Healthy Nutrition and Dietetics. 2018;3(5):2-11.
54. Tripathi AK, Dhasade VV. Formulation Development and Standardisation of Herbal Hair Tonic. International Journal of Pharmaceutical Research and Applications Volume 7, Issue 5 Sep-Oct 2022, pp: 617-624.
55. Van der Veen C, Handjiski B, Paus R, Müller-Röver S, Maurer M, Eichmüller S, Ling G, Hofmann U, Foitzik K, Mecklenburg L. A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis. Journal of Investigative Dermatology. 1999 Oct 1;113(4):523-32.
56. Yadav M, Jain S, Tomar R, Prasad GB, Yadav H. Medicinal and biological potential of pumpkin: an updated review. Nutrition research reviews. 2010 Dec;23(2):184-90.
2. Abou-Zeid SM, AbuBakr HO, Mohamed MA, El-Bahrawy A. Ameliorative effect of pumpkin seed oil against emamectin induced toxicity in mice. Biomedicine & Pharmacotherapy. 2018 Feb 1;98:242-51.
3. Adams GG, Imran S, Wang S, Mohammad A, Kok S, Gray DA, Channell GA, Morris GA, Harding SE. The hypoglycaemic effect of pumpkins as anti-diabetic and functional medicines. Food Research International. 2011 May 1;44(4):862-7.
4. Adnan M, Gul S, Batool S, Fatima B, Rehman A, Yaqoob S, Shabir H, Yousaf T, Mussarat S, Ali N, Khan SN. A review on the ethnobotany, phytochemistry, pharmacology and nutritional composition of Cucurbita pepo L. The Journal of Phytopharmacology. 2017;6(2):133-9.
5. Aktaş N, Uzlaşır T, Tunçil YE. Pre-roasting treatments significantly impact thermal and kinetic characteristics of pumpkin seed oil. Thermochimica Acta. 2018 Nov 10;669:109-15.
6. Albakry Z, Karrar E, Ahmed IA, Oz E, Proestos C, El Sheikha AF, Oz F, Wu G, Wang X. Nutritional composition and volatile compounds of black cumin (Nigella sativa L.) seed, fatty acid composition and tocopherols, polyphenols, and antioxidant activity of its essential oil. Horticulturae. 2022 Jun 24;8(7):575.
7. Almohanna HM, Ahmed AA, Tsatalis JP, Tosti A. The role of vitamins and minerals in hair loss: a review. Dermatology and therapy. 2019 Mar;9(1):51-70.
8. Amin MZ, Islam T, Uddin MR, Uddin MJ, Rahman MM, Satter MA. Comparative study on nutrient contents in the different parts of indigenous and hybrid varieties of pumpkin (Cucurbita maxima Linn.). Heliyon. 2019 Sep 1;5(9).
9. Aziz AR, AbouLaila MR, Aziz M, Omar MA, Sultan K. In vitro and in vivo anthelmintic activity of pumpkin seeds and pomegranate peels extracts against Ascaridia galli. Beni-Suef University Journal of Basic and Applied Sciences. 2018 Jun 1;7(2):231-4.
10. Carlotto J, da Silva LM, Dartora N, Maria-Ferreira D, Sabry DD, Arquimedes Filho PS, de Paula Werner MF, Sassaki GL, Gorin PA, Iacomini M, Cipriani TR. Identification of a dicaffeoylquinic acid isomer from Arctium lappa with a potent anti-ulcer activity. Talanta. 2015 Apr 1;135:50-7.
11. Demay MB, MacDonald PN, Skorija K, Dowd DR, Cianferotti L, Cox M. Role of the vitamin D receptor in hair follicle biology. The Journal of steroid biochemistry and molecular biology. 2007 Mar 1;103(3-5):344-6.
12. Dotto JM, Chacha JS. The potential of pumpkin seeds as a functional food ingredient: A review. Scientific African. 2020 Nov 1;10:e00575.
13. Eduardovna KN, Alexandrovich KS, Valentinovna IN, Yurievna AN, Vladimirovna KD, Sergeevich BR, Vladimirovna ZL, Hasan AA, Anatolevich BR. Pharmacognostic Studies of the Leaves and Fructus of Arctium lappa L.(Asteraceae Bercht. & J. Presl). Pharmacognosy Journal. 2021;13(6s).
14. El-Mahmoudy A, Matsuyama H, Borgan MA, Shimizu Y, El-Sayed MG, Minamoto N, Takewaki T. Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages. International immunopharmacology. 2002 Oct 1;2(11):1603-11.
15. Farhan N, Salih N, Salimon J. A REVIEW ON OLIVE OIL AND Nigella sativa L. BLACK CUMIN SEED OIL: COMPOSITION AND BIOLOGICAL ACTIVITY. Rasayan Journal of Chemistry. 2021 Oct 1;14(4).
16. Goldberg LJ, Lenzy Y. Nutrition and hair. Clinics in dermatology. 2010 Jul 1;28(4):412-9.
17. Hajhashemi V, Rajabi P, Mardani M. Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model. Avicenna journal of phytomedicine. 2019 Nov;9(6):499.
18. Halver JE. The vitamins. InFish nutrition 2003 Jan 1 (pp. 61-141). Academic Press.
19. Hannan MA, Rahman MA, Sohag AA, Uddin MJ, Dash R, Sikder MH, Rahman MS, Timalsina B, Munni YA, Sarker PP, Alam M. Black cumin (Nigella sativa L.): A comprehensive review on phytochemistry, health benefits, molecular pharmacology, and safety. Nutrients. 2021 May 24;13(6):1784.
20. Hardy MH. The secret life of the hair follicle. Trends in Genetics. 1992 Feb 1;8(2):55-61.
21. Hossain MS, Sharfaraz A, Dutta A, Ahsan A, Masud MA, Ahmed IA, Goh BH, Urbi Z, Sarker MM, Ming LC. A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L. Biomedicine & Pharmacotherapy. 2021 Nov 1;143:112182.
22. Houschyar KS, Borrelli MR, Tapking C, Popp D, Puladi B, Ooms M, Chelliah MP, Rein S, Pförringer D, Thor D, Reumuth G. Molecular mechanisms of hair growth and regeneration: current understanding and novel paradigms. Dermatology. 2020 Mar 12;236(4):271-80.
23. Ibrahim IM, Hasan MS, Elsabaa KI, Elsaie ML. Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: A randomized comparative trial. Journal of Cosmetic Dermatology. 2021 Sep;20(9):2867-73.
24. Krause K, Foitzik K. Biology of the hair follicle: the basics. InSeminars in cutaneous medicine and surgery 2006 Mar 1 (Vol. 25, No. 1, pp. 2-10). Philadelphia, PA: WB Saunders Co., c1996.
25. Lestari B, Meiyanto E. A review: the emerging nutraceutical potential of pumpkin seeds. Indonesian Journal of Cancer Chemoprevention. 2018 Jul 3;9(2):92-101.
26. Lim TK. Edible medicinal and non-medicinal plants. Dordrecht, The Netherlands:: Springer; 2012.
27. Lindner G, Botchkarev VA, Botchkareva NV, Ling G, van der Veen C, Paus R. Analysis of apoptosis during hair follicle regression (catagen). The American journal of pathology. 1997 Dec;151(6):1601.
28. Matsui T, Guth H, Grosch W. A comparative study of potent odorants in peanut, hazelnut, and pumpkin seed oils on the basis of aroma extract dilution analysis (AEDA) and gas chromatography‐olfactometry of headspace samples (GCOH). Lipid/Fett. 1998 Feb;100(2):51-6.
29. Meenakshisundaram A, Harikrishnan TJ, Anna T. Anthelmintic evaluation of Cucurbita pepo against gastrointestinal nematodes of sheep. Indian Journal of Animal Research. 2017;51(3):518-24.
30. Milner Y, Kashgarian M, Sudnik J, Filippi M, Kizoulis M, Stenn K. Exogen, shedding phase of the hair growth cycle: characterization of a mouse model. Journal of Investigative Dermatology. 2002 Sep 1;119(3):639-44.
31. Mir SA, Dar LA, Ali T, Kareem O, Rashid R, Khan NA, Chashoo IA, Bader GN. Arctium lappa: A review on its phytochemistry and pharmacology. Edible Plants in Health and Diseases: Volume II: Phytochemical and Pharmacological Properties. 2022 Mar 15:327-48.
32. Moraru DI, Ploscutanu G, Stoica M. Health benefits of edible round-fruited types of Cucurbita pepo-a short review. Journal of Agroalimentary Processes and Technologies. 2018;24(3):202-6.
33. Müller-Röver S, Foitzik K, Paus R, Handjiski B, van der Veen C, Eichmüller S, McKay IA, Stenn KS. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. Journal of investigative dermatology. 2001 Jul 1;117(1):3-15.
34. ONAR HÇ, Hasniye YA. New Natural Inventions Against Hair Loss (Alopecia). PIONEER AND CONTEMPORARY STUDIES IN NATURAL SCIENCE AND MATHEMATICS. 2023 Jul 17:41-58.
35. Patel S, Sharma V, S Chauhan N, Thakur M, Dixit VK. Hair growth: focus on herbal therapeutic agent. Current drug discovery technologies. 2015 Mar 1;12(1):21-42.
36. Paulsen E. Contact sensitization from Compositae‐containing herbal remedies and cosmetics. Contact Dermatitis. 2002 Oct;47(4):189-98.
37. Paus R, Cotsarelis G. The biology of hair follicles. New England journal of medicine. 1999 Aug 12;341(7):491-7.
38. Penkar GM, Salkar MR, Chavan PS, Ambade MS, Parab SA, Padte TS, Salgoankar PL, Sawant MM, Jagtap VA. An Overview on Indian Herbs in Hair Care Therapy. Research Journal of Pharmacognosy and Phytochemistry. 2023 Apr 1;15(2):161-6.
39. Rajsekhar S, Kuldeep B. Pharmacognosy and pharmacology of Nigella sativa-A review. International Research Journal of Pharmacy. 2011;2(11):36-9.
40. Randall VA, Botchkareva NV. The biology of hair growth. Cosmetics Applications of Laser & Light-Based Systems. 2009 Jan 1:3-5.
41. Ratnam N, Naijibullah M, Ibrahim MD. A review on Cucurbita pepo. Int J Pharm Phytochem Res. 2017;9:1190-4.
42. Rifat-Uz-Zaman MS, Khan MS. Gastroprotective and anti-secretory effect of Nigella sativa seed and its extracts in indomethacin-treated rats. Pak J Biol Sci. 2004;7:995-1000.
43. Ruwanthika KH, Munasinghe MM, Marapana RU. Overview of Cucurbita spp.(pumpkin) and development of value-added products emphasizing its nutritional and chemical composition. World Journal of Advanced Research and Reviews. 2023;18(2):1215-26.
44. Salama M, Salama SG. Arctium lappa L.(Asteraceae); a new invasive highly specific medicinal plant growing in Egypt. Pyrex Journal of Plant and Agricultural Research. 2016.
45. Saraf S, Jharaniya M, Gupta A, Jain V, Saraf S. Herbal hair cosmetics: advancements and recent findings. World J Pharm Res. 2014 Jan 8;3(2):3278-94.
46. Satheeshan KN, Seema BR, Manjusha AM. Development and evaluation of VCO based herbal hair tonic. Journal of Pharmacognosy and Phytochemistry. 2020;9(3):485-93.
47. Sayyad TR, Chaudhari SS, Nikumbh PP, Bhurat MR. EVALUATION, COMPOSITION AND COMPARATIVE STUDY OF HAIR GROWING TONIC, Pharmaceutical Resonance 2023 Vol. VI - Issue I.
48. Schneider MR, Schmidt-Ullrich R, Paus R. The hair follicle as a dynamic miniorgan. Current biology. 2009 Feb 10;19(3):R132-42.
49. Semalty M, Semalty A, Joshi GP, Rawat MS. Hair growth and rejuvenation: an overview. Journal of dermatological treatment. 2011 Jun 1;22(3):123-32.
50. Shafiq H, Ahmad A, Masud T, Kaleem M. Cardio-protective and anti-cancer therapeutic potential of Nigella sativa. Iranian journal of basic medical sciences. 2014 Dec;17(12):967.
51. Shergill-Bonner R. Micronutrients. Paediatrics and Child Health. 2017 Aug 1;27(8):357-62.
52. Thakur S, Kaurav H, Chaudhary G. Nigella sativa (Kalonji): A black seed of miracle. International Journal of Research and Review. 2021;8(4):342-57.
53. Tkacheva N, Eliseeva T. Burdock (lat. Árctium). Journal of Healthy Nutrition and Dietetics. 2018;3(5):2-11.
54. Tripathi AK, Dhasade VV. Formulation Development and Standardisation of Herbal Hair Tonic. International Journal of Pharmaceutical Research and Applications Volume 7, Issue 5 Sep-Oct 2022, pp: 617-624.
55. Van der Veen C, Handjiski B, Paus R, Müller-Röver S, Maurer M, Eichmüller S, Ling G, Hofmann U, Foitzik K, Mecklenburg L. A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis. Journal of Investigative Dermatology. 1999 Oct 1;113(4):523-32.
56. Yadav M, Jain S, Tomar R, Prasad GB, Yadav H. Medicinal and biological potential of pumpkin: an updated review. Nutrition research reviews. 2010 Dec;23(2):184-90.
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Jan 16, 2024
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Dolly M. Patel, Kuntupalli Sandhya Rani, & Dr. Pragnesh Patani. (2024). “A COMPREHENSIVE REVIEW OF BOTANICAL INGREDIENTS LIKE PUMPKIN SEEDS, BLACK CUMIN SEEDS AND BURDOCK ROOTS AND THEIR EFFICACY FOR HEALTHY HAIR AND PREVENTING PREMATURE GRAYING OF HAIRS.”. Journal of Population Therapeutics and Clinical Pharmacology, 31(1), 2171–2188. https://doi.org/10.53555/jptcp.v31i1.4442
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Author Biographies
Dolly M. Patel
Student, Khyati College of Pharmacy, Palodia, Ahmedabad
Kuntupalli Sandhya Rani
Assistant Professor, Khyati College of Pharmacy, Palodia, Ahmedabad
Dr. Pragnesh Patani
Principal and Professor, Khyati College of Pharmacy, Palodia, Ahmedabad