Bio Reduction Of Zinc Oxide Nanoparticles Using Ipomoea Batatas & Its Antidiabetic Activity
Main Article Content
Keywords
Diabetes, Potato, Metabolism, Insulin, Pancreas, Inhibition
Abstract
Introduction: Ipomea batatas (sweet potato) have high fiber content, good choice for diabetes, lower blood sugar that does nothing but control blood sugar. This attempt was done by a photochemical study of the extract which revealed the presence of glycosides, glucosinolates, and alkaloids, a pre medicine for type 2 diabetes mellitus. This study is to analyze the efficacy of anti-diabetic activity of Ipomea batatas with synthesized zinc oxide nanoparticles.
Materials And Methods: Ipomea batatas weighing 10g added with 0.574g of zinc oxide nanoparticles & 100 ml of NaOH. The mixture is then subjected to heating or condensation for 5 minutes in a water bath. It is repeated and the mixture is allowed to condense to 5 ml & used for the alpha amylase test and glucosidase test. Ipomea batatas with zinc oxide nanoparticles have shown more activity against diabetes compared with standard.
Results Conclusion: Our results showed that Ipomea batatas with silver nanoparticles have good anti-diabetic activity when compared to the standard.
Conclusion: In future, this can be considered in the pharmaceutical companies & used as an adjuvant rather than promoting higher doses of insulin and oral drugs.
References
1. Begum JS, Manjunath K, Pratibha S, Dhananjaya N, Sahu P, Kashaw S. Bioreduction synthesis of zinc oxide nanoparticles using Delonix regia leaf extract (Gul Mohar) and its agro medicinal applications. Journal of Science: Advanced Materials and Devices. 2020 Dec 1;5(4):468-75.
2. Begum,J.S Manjunath,K.Pratibha ,s.Dhanajaya ‘Bioreduction synthesis of zinc oxide nanoparticles using Delonix renal leaf extract and agro medicinal applications’,2020.
3. Tahir IM, Akhter N, Parveen A, Mehboob H, Saleem S, Munir N, Ali Shah SM, Zaheer J, Khan FS, Sultana S, Akram M. Effects of methanolic and aqueous extracts of Ipomoea batatas L on mineral contents level (calcium and magnesium) in alloxan-induced diabetic rats. Pakistan Journal of Pharmaceutical Sciences. 2018 Sep 2.
4. Akhtar N, Akram M, Daniyal M, Ahmad S. Evaluation of antidiabetic activity of Ipomoea batatas L. extract in alloxan-induced diabetic rats. International journal of immunopathology and pharmacology. 2018 Nov;32:2058738418814678
5. Kamal S, Akhter N, Khan SG, Kiran S, Farooq T, Akram M, Shah SM, Tahir IM, Akhlaq M, Said F, Zaheer J. Anti-diabetic activity of aqueous extract of Ipomoea batatas L. in alloxan induced diabetic Wistar rats and its effects on biochemical parameters in diabetic rats. Pakistan Journal of Pharmaceutical Sciences. 2018 Jul 2;31.
6. Li F, Li Q, Gao D, Peng Y. The optimal extraction parameters and anti-diabetic activity of flavonoids from Ipomoea batatas leaf. AfricanJournal of Traditional, Complementary and Alternative Medicines. 2009;6(2).
7. Kusano S, Abe H, Tamura H. Isolation of antidiabetic components from white-skinned sweet potato (Ipomoea batatas L.). Bioscience, biotechnology, and biochemistry. 2001 Jan 1;65(1):109-14.
8. Panda V, Sonkamble M. Phytochemical constituents and pharmacological activities of Ipomoea batatas l.(Lam)–A review. International Journal of Research in Phytochemistry and Pharmacology. 2012 Feb 29;2(1):25-34.
9. Wang P, Su Z, Yuan W, Deng G, Li S. Phytochemical constituents and pharmacological activities of Eryngium L.(Apiaceae).
10. Khalafi T, Buazar F, Ghanemi K. Psychosynthesis and enhanced photocatalytic activity of zinc oxide nanoparticles toward organosulfur pollutants. Scientific reports. 2019 May 3;9(1):1-0.
11. Abidin, P. E., E. Dery, F. Kweku Amagloh, K. Asare, and E. E. Crey. 2015. Training of Trainers’ Module for Orange-Fleshed Sweetpotato (OFSP).: Utilization and Processing. International Potato Center.
12. Anita, Ramesh, Arumugam Paramasivam, Jayaseelan Vijayashree Priyadharsini, and Srinivasan Chitra. 2020. “The m6A Readers YTHDF1 and YTHDF3 Aberrations Associated with Metastasis and Predict Poor Prognosis in Breast Cancer Patients.” American Journal of Cancer Research 10 (8): 2546–54.
13. Barabadi, Hamed, Faraz Mojab, Hossein Vahidi, Boshra Marashi, Niloufar Talank, Omid Hosseini, and Muthupandian Saravanan. 2021. “Green Synthesis, Characterization, Antibacterial and Biofilm Inhibitory Activity of Silver Nanoparticles Compared to Commercial Silver Nanoparticles.” Inorganic Chemistry Communications. https://doi.org/10.1016/j.inoche.2021.108647.
14. Campos, Hugo, and Oscar Ortiz. 2019. The Potato Crop: Its Agricultural, Nutritional and Social Contribution to Humankind. Springer Nature.
15. Díaz-Gerevini, Gustavo Tomás, Alejandro Daín, María Eugenia Pasqualini, Cristina B. López, Aldo R. Eynard, and Gastón Repossi. 2019. “Diabetic Encephalopathy: Beneficial Effects of Supplementation with Fatty Acids ω3 and Nordihydroguaiaretic Acid in a Spontaneous Diabetes Rat Model.” Lipids in Health and Disease 18 (1): 43.
16. Faruqui, Arif. 2017. “Post Prandial Hyperglycemia: A Real Threat for Patients with Type 2 Diabetes Mellitus.” Advances in Diabetes and Metabolism. https://doi.org/10.13189/adm.2017.050302.
17. Feather, Adam, David Randall, and Mona Waterhouse. 2020. Kumar and Clark’s Clinical
Medicine. Elsevier.“Fig. 1. Features of Treatment to Reduce the Risk of Complications of Cardiovascular Disease in Patients with Diabetes Mellitus: SS - Cardiovascular; HDL Cholesterol - High Density Lipoprotein Cholesterol; LDL Cholesterol - Low Density Lipoprotein Cholesterol; PCSK-9 - Subtilizine / Kexin Type 9 Protein Convertase; TG - Triglycerides; OH - Total Cholesterol.” n.d. https://doi.org/10.14341/dm10351-5216.
18. Ganapathy, Dhanraj, Ramya Ramadoss, Monal Yuwanati, and Murthykumar Karthikeyan. 2022. “Rarity of Mucormycosis in Oral Squamous Cell Carcinoma: A Clinical Paradox?” Oral Oncology 125 (February): 105725.
19. Gougeon, R., K. Styhler, J. A. Morais, P. J. Jones, and E. B. Marliss. 2000. “Effects of Oral Hypoglycemic Agents and Diet on Protein Metabolism in Type 2 Diabetes.” Diabetes Care. https://doi.org/10.2337/diacare.23.1.1.
20. Gowhari Shabgah, Arezoo, Azwar Amir, Zhanna R. Gardanova, Angelina Olegovna Zekiy, Lakshmi Thangavelu, Maryam Ebrahimi Nik, Majid Ahmadi, and Jamshid Gholizadeh Navashenaq. 2021. “Interleukin-25: New Perspective and State-of-the-Art in Cancer Prognosis and Treatment Approaches.” Cancer Medicine 10 (15): 5191–5202.
21. Gupta, Twinkle, Nilanjan Das, and Sabiha Imran. 2019. “The Prevention and Therapy of Osteoporosis: A Review on Emerging Trends from Hormonal Therapy to Synthetic Drugs to Plant-Based Bioactives.” Journal of Dietary Supplements. https://doi.org/10.1080/19390211.2018.1472715.
22. Habtemariam, Solomon. 2019. Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases: The Chemical and Pharmacological Basis of Their Action. Academic Press.
23. Kanniah, Paulkumar, Jila Radhamani, Parvathiraja Chelliah, Natarajan Muthusamy, Emmanuel Joshua Jebasingh Sathiya Balasingh, Jesi Reeta Thangapandi, Subburathinam Balakrishnan, and Rajeshkumar Shanmugam. 2020. “Green Synthesis of Multifaceted Silver Nanoparticles Using the Flower Extract of Aerva Lanata and Evaluation of Its Biological and Environmental Applications.” ChemistrySelect 5 (7): 2322–31.
24. Kumar, K. V. S. Hari, K. V. Hari Kumar, and S. K. Patnaik. 2018. “A Long Term Follow-up Study from India Assessing the Risk of Diabetes Mellitus in Service Population.” Diabetes & Metabolic Syndrome: Clinical Research & Reviews. https://doi.org/10.1016/j.dsx.2017.09.002.
25. Muthukrishnan, Lakshmipathy. 2021. “Multidrug Resistant Tuberculosis - Diagnostic Challenges and Its Conquering by Nanotechnology Approach- An Overview.” Chemico-Biological Interactions 337 (March): 109397.
26. PradeepKumar, Angambakkam Rajasekharan, Hagay Shemesh, Malli Sureshbabu Nivedhitha, M. Mohamed Jubair Hashir, Selva Arockiam, Tirupambaram Natarajasundaram Uma Maheswari, and Velmurugan Natanasabapathy. 2021. “Diagnosis of Vertical Root Fractures by Cone-Beam Computed Tomography in Root-Filled Teeth with Confirmation by Direct Visualization: A Systematic Review and Meta-Analysis.” Journal of Endodontia 47 (8): 1198–1214.
27. Ramesh Kumar, K. R., K. K. Shanta Sundari, A. Venkatesan, and Shymalaa Chandrasekar. 2011. “Depth of Resin Penetration into Enamel with 3 Types of Enamel Conditioning Methods: A Confocal Microscopic Study.” American Journal of Orthodontics and Dentofacial Orthopedics: Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics 140 (4):
479–85.
28. Samuel, Srinivasan Raj, Syed Kuduruthullah, Al Moutassem Billah Khair, Maher Al Shayeb, Abed Elkaseh, Sudhir Rama Varma, Gulrez Nadeem, Issameldin Abdalla Elkhader, and Awad Ashekhi. 2021. “Impact of Pain, Psychological-Distress, SARS-CoV2 Fear on Adults’ OHRQOL during COVID-19 Pandemic.” Saudi Journal of Biological Sciences 28 (1): 492–94.
29. Vaidya, Ashok, Rama Vaidya, and Nutan Nabar. 2014. “Current Status of Indigenous Drugs and Alternative Medicine in the Management of Diabetes Mellitus.” RSSDI Textbook of Diabetes Mellitus. https://doi.org/10.5005/jp/books/12626_46.
30. Xu, Linlin, Wei Wang, and Wei Song. 2022. “A Combination of Metformin and Insulin Improve Cardiovascular and Cerebrovascular Risk Factors in Individuals with Type 1 Diabetes Mellitus.” Diabetes Research and Clinical Practice 191 (September): 110073.
2. Begum,J.S Manjunath,K.Pratibha ,s.Dhanajaya ‘Bioreduction synthesis of zinc oxide nanoparticles using Delonix renal leaf extract and agro medicinal applications’,2020.
3. Tahir IM, Akhter N, Parveen A, Mehboob H, Saleem S, Munir N, Ali Shah SM, Zaheer J, Khan FS, Sultana S, Akram M. Effects of methanolic and aqueous extracts of Ipomoea batatas L on mineral contents level (calcium and magnesium) in alloxan-induced diabetic rats. Pakistan Journal of Pharmaceutical Sciences. 2018 Sep 2.
4. Akhtar N, Akram M, Daniyal M, Ahmad S. Evaluation of antidiabetic activity of Ipomoea batatas L. extract in alloxan-induced diabetic rats. International journal of immunopathology and pharmacology. 2018 Nov;32:2058738418814678
5. Kamal S, Akhter N, Khan SG, Kiran S, Farooq T, Akram M, Shah SM, Tahir IM, Akhlaq M, Said F, Zaheer J. Anti-diabetic activity of aqueous extract of Ipomoea batatas L. in alloxan induced diabetic Wistar rats and its effects on biochemical parameters in diabetic rats. Pakistan Journal of Pharmaceutical Sciences. 2018 Jul 2;31.
6. Li F, Li Q, Gao D, Peng Y. The optimal extraction parameters and anti-diabetic activity of flavonoids from Ipomoea batatas leaf. AfricanJournal of Traditional, Complementary and Alternative Medicines. 2009;6(2).
7. Kusano S, Abe H, Tamura H. Isolation of antidiabetic components from white-skinned sweet potato (Ipomoea batatas L.). Bioscience, biotechnology, and biochemistry. 2001 Jan 1;65(1):109-14.
8. Panda V, Sonkamble M. Phytochemical constituents and pharmacological activities of Ipomoea batatas l.(Lam)–A review. International Journal of Research in Phytochemistry and Pharmacology. 2012 Feb 29;2(1):25-34.
9. Wang P, Su Z, Yuan W, Deng G, Li S. Phytochemical constituents and pharmacological activities of Eryngium L.(Apiaceae).
10. Khalafi T, Buazar F, Ghanemi K. Psychosynthesis and enhanced photocatalytic activity of zinc oxide nanoparticles toward organosulfur pollutants. Scientific reports. 2019 May 3;9(1):1-0.
11. Abidin, P. E., E. Dery, F. Kweku Amagloh, K. Asare, and E. E. Crey. 2015. Training of Trainers’ Module for Orange-Fleshed Sweetpotato (OFSP).: Utilization and Processing. International Potato Center.
12. Anita, Ramesh, Arumugam Paramasivam, Jayaseelan Vijayashree Priyadharsini, and Srinivasan Chitra. 2020. “The m6A Readers YTHDF1 and YTHDF3 Aberrations Associated with Metastasis and Predict Poor Prognosis in Breast Cancer Patients.” American Journal of Cancer Research 10 (8): 2546–54.
13. Barabadi, Hamed, Faraz Mojab, Hossein Vahidi, Boshra Marashi, Niloufar Talank, Omid Hosseini, and Muthupandian Saravanan. 2021. “Green Synthesis, Characterization, Antibacterial and Biofilm Inhibitory Activity of Silver Nanoparticles Compared to Commercial Silver Nanoparticles.” Inorganic Chemistry Communications. https://doi.org/10.1016/j.inoche.2021.108647.
14. Campos, Hugo, and Oscar Ortiz. 2019. The Potato Crop: Its Agricultural, Nutritional and Social Contribution to Humankind. Springer Nature.
15. Díaz-Gerevini, Gustavo Tomás, Alejandro Daín, María Eugenia Pasqualini, Cristina B. López, Aldo R. Eynard, and Gastón Repossi. 2019. “Diabetic Encephalopathy: Beneficial Effects of Supplementation with Fatty Acids ω3 and Nordihydroguaiaretic Acid in a Spontaneous Diabetes Rat Model.” Lipids in Health and Disease 18 (1): 43.
16. Faruqui, Arif. 2017. “Post Prandial Hyperglycemia: A Real Threat for Patients with Type 2 Diabetes Mellitus.” Advances in Diabetes and Metabolism. https://doi.org/10.13189/adm.2017.050302.
17. Feather, Adam, David Randall, and Mona Waterhouse. 2020. Kumar and Clark’s Clinical
Medicine. Elsevier.“Fig. 1. Features of Treatment to Reduce the Risk of Complications of Cardiovascular Disease in Patients with Diabetes Mellitus: SS - Cardiovascular; HDL Cholesterol - High Density Lipoprotein Cholesterol; LDL Cholesterol - Low Density Lipoprotein Cholesterol; PCSK-9 - Subtilizine / Kexin Type 9 Protein Convertase; TG - Triglycerides; OH - Total Cholesterol.” n.d. https://doi.org/10.14341/dm10351-5216.
18. Ganapathy, Dhanraj, Ramya Ramadoss, Monal Yuwanati, and Murthykumar Karthikeyan. 2022. “Rarity of Mucormycosis in Oral Squamous Cell Carcinoma: A Clinical Paradox?” Oral Oncology 125 (February): 105725.
19. Gougeon, R., K. Styhler, J. A. Morais, P. J. Jones, and E. B. Marliss. 2000. “Effects of Oral Hypoglycemic Agents and Diet on Protein Metabolism in Type 2 Diabetes.” Diabetes Care. https://doi.org/10.2337/diacare.23.1.1.
20. Gowhari Shabgah, Arezoo, Azwar Amir, Zhanna R. Gardanova, Angelina Olegovna Zekiy, Lakshmi Thangavelu, Maryam Ebrahimi Nik, Majid Ahmadi, and Jamshid Gholizadeh Navashenaq. 2021. “Interleukin-25: New Perspective and State-of-the-Art in Cancer Prognosis and Treatment Approaches.” Cancer Medicine 10 (15): 5191–5202.
21. Gupta, Twinkle, Nilanjan Das, and Sabiha Imran. 2019. “The Prevention and Therapy of Osteoporosis: A Review on Emerging Trends from Hormonal Therapy to Synthetic Drugs to Plant-Based Bioactives.” Journal of Dietary Supplements. https://doi.org/10.1080/19390211.2018.1472715.
22. Habtemariam, Solomon. 2019. Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases: The Chemical and Pharmacological Basis of Their Action. Academic Press.
23. Kanniah, Paulkumar, Jila Radhamani, Parvathiraja Chelliah, Natarajan Muthusamy, Emmanuel Joshua Jebasingh Sathiya Balasingh, Jesi Reeta Thangapandi, Subburathinam Balakrishnan, and Rajeshkumar Shanmugam. 2020. “Green Synthesis of Multifaceted Silver Nanoparticles Using the Flower Extract of Aerva Lanata and Evaluation of Its Biological and Environmental Applications.” ChemistrySelect 5 (7): 2322–31.
24. Kumar, K. V. S. Hari, K. V. Hari Kumar, and S. K. Patnaik. 2018. “A Long Term Follow-up Study from India Assessing the Risk of Diabetes Mellitus in Service Population.” Diabetes & Metabolic Syndrome: Clinical Research & Reviews. https://doi.org/10.1016/j.dsx.2017.09.002.
25. Muthukrishnan, Lakshmipathy. 2021. “Multidrug Resistant Tuberculosis - Diagnostic Challenges and Its Conquering by Nanotechnology Approach- An Overview.” Chemico-Biological Interactions 337 (March): 109397.
26. PradeepKumar, Angambakkam Rajasekharan, Hagay Shemesh, Malli Sureshbabu Nivedhitha, M. Mohamed Jubair Hashir, Selva Arockiam, Tirupambaram Natarajasundaram Uma Maheswari, and Velmurugan Natanasabapathy. 2021. “Diagnosis of Vertical Root Fractures by Cone-Beam Computed Tomography in Root-Filled Teeth with Confirmation by Direct Visualization: A Systematic Review and Meta-Analysis.” Journal of Endodontia 47 (8): 1198–1214.
27. Ramesh Kumar, K. R., K. K. Shanta Sundari, A. Venkatesan, and Shymalaa Chandrasekar. 2011. “Depth of Resin Penetration into Enamel with 3 Types of Enamel Conditioning Methods: A Confocal Microscopic Study.” American Journal of Orthodontics and Dentofacial Orthopedics: Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics 140 (4):
479–85.
28. Samuel, Srinivasan Raj, Syed Kuduruthullah, Al Moutassem Billah Khair, Maher Al Shayeb, Abed Elkaseh, Sudhir Rama Varma, Gulrez Nadeem, Issameldin Abdalla Elkhader, and Awad Ashekhi. 2021. “Impact of Pain, Psychological-Distress, SARS-CoV2 Fear on Adults’ OHRQOL during COVID-19 Pandemic.” Saudi Journal of Biological Sciences 28 (1): 492–94.
29. Vaidya, Ashok, Rama Vaidya, and Nutan Nabar. 2014. “Current Status of Indigenous Drugs and Alternative Medicine in the Management of Diabetes Mellitus.” RSSDI Textbook of Diabetes Mellitus. https://doi.org/10.5005/jp/books/12626_46.
30. Xu, Linlin, Wei Wang, and Wei Song. 2022. “A Combination of Metformin and Insulin Improve Cardiovascular and Cerebrovascular Risk Factors in Individuals with Type 1 Diabetes Mellitus.” Diabetes Research and Clinical Practice 191 (September): 110073.
Article Sidebar
Published
Jun 25, 2023
Article Details
How to Cite
Sriraj Gannamaneni, Suganya Panneer Selvam, Rajeshkumar Shanmugam, Ramya Ramadoss, Sandhya Sundar, & Pratibha Ramani. (2023). Bio Reduction Of Zinc Oxide Nanoparticles Using Ipomoea Batatas & Its Antidiabetic Activity. Journal of Population Therapeutics and Clinical Pharmacology, 30(7), 439–445. https://doi.org/10.47750/jptcp.2023.30.07.048
Issue
Section
Articles
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.