PROTON PUMP INHIBITOR MISUSE IN A TERTIARY CARE SETTING FOR THE PREVENTION OF STRESS ULCERS
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Keywords
Proton Pump Inhibitor, Misuse, Prevention, Stress Ulcers
Abstract
Background: Proton Pump Inhibitor is now one of the most potent medicines in the word due to its increasing prescription, due to its remarkable effectiveness and safety profile. But many people use these drugs without the doctor prescription for the prevention of stress ulcer which leads to undesirable effects in the human body.
Objective: The aim of the study was to find out Proton Pump Inhibitor misuse in a Tertiary Care Setting for the Prevention of Stress Ulcers
Methodology: The current prospective study was conducted at the Department of medicine, Bolan medical college/ Bolan medical complex hospital Quetta from January 2023 to July 2023 after taking approval from the ethical committee of the institute. A total of 204 individuals who were admitted in the hospital and got PPI were enrolled. PPI appropriately indicated participants were those who were taking Proton pump inhibitors due to disease selected by American Gastroenterology Association (AGA) while individuals PPI inappropriately were those who were taking PPIs without disease described by AGA. Data was analyzed through SPSS and entered into Microsoft excel and presented in the form of frequency and percentages.
Results: A total of 204 patients took part in the current study, out of the total proton pump inhibitor formulation the most prevalent was esomeprazole 112(54.90%) followed by omeprazole 81(39.7%) and Dexlanprazole 11(5.3%) received by the study population respectively. 152(74.50%) individuals taken the medicines orally and 52(25.4%) in injectable form (IV). The doses of omeprazole and esomeprazole were 40mg in 182 (89.2%) and 30mg Dexlansoprazole 9(4.4%). There were 13(6.3%) patients who continuously received omeprazole infusion of 9 mg per hour. The frequency of PPI was once a day in 182 (89.2%), Twice a day in 16(7.8%) and continuous infusion in 6(2.9%). Out of 204 Participants 142(69.60%) received PPI without any specific indication while 62(30.3%) taken with appropriate indication.
Conclusion: Our study concluded that misuse of Proton pump inhibitors is very common among hospitalized patients. Institutional rules, evidence-based medicine education, and frequent treatment plan reviews are necessary to avoid the incorrect use of PPIs.
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Samreen Bugti
Assistant professor, Department of medicine, Bolan medical college/ Bolan medical complex hospital Quetta
Tariq Mehmood
Medicine PGMI/sheikh Khalifa Bin Zayyed al nehan hospital Quetta
Tahira
Assistant professor, Department of medicine, Bolan medical college/ Bolan medical complex hospital Quetta
Taqdees Zahra
Assistant professor Medicine department, Bolan Medical College/ Bolan medical complex hospital Quetta