ASSOCIATION OF VITAMIN D DEFICIENCY WITH TUBERCULOSIS IN ADULT PATIENTS REPORTING TO A TERTIARY CARE HOSPITAL
Main Article Content
Keywords
Association, Vitamin D deficiency, Tuberculosis
Abstract
Background: Tuberculosis is a life threatening disease and lack of vitamin D has been linked to an increased risk of tuberculosis.
Objective: The aim of the current study was to explore the association of vitamin D deficiency with tuberculosis in adult patients.
Methodology: The current case control study was carried out at the Department of medicine, Bolan medical college/ Bolan medical complex hospital Quetta. The study duration was one year from July 2023 to August 2024 after taking permission from the ethical committee of the institute. A total of 52 individuals with lung infections were enrolled and 52 age and gender matched controls were also included. For the identification of tuberculosis the sputum of each individual was examine through the gene Xpert technology. Vitamin D insufficiency was diagnosed based on serum 25-hydroxvitamin D level <50 nmol/l. SPSS version 20 was used for analyzing the data.
Results: When comparing the mean vitamin D levels between the participants and controls, there was a statistically significant difference (with a p<0.001). It was shown that 18 (34.6%) controls and 49 participants (94%) had insufficient vitamin D. (95%, Odd's Ratio = 3.8) 0.001, with a p<0.001), CI corresponds to 2.423—5.999. MDR Tuberculosis participants had mean vitamin D level was 22.38 ± 16.60 nmol/l, although the variation was deemed insignificant (p > 0.05). Sensitive individuals with TB had mean levels of vitamin D in their serum of 18.55 ± 9.99 nmol/l.
Conclusion: Participants with recent tuberculosis diagnoses showed signs of severe vitamin D insufficiency. Although a link between vitamin D deficiency and TB has been reported, its causative function has not been demonstrated.
References
2. Ho-Pham LT, Nguyen ND, Nguyen TT, Nguyen DH, Bui PK, Nguyen VN, et al. Association between vitamin D insufficiency and tuberculosis in a Vietnamese population. BMC infectious diseases 2010; 10(1):306.
3. Chandra G, Selvaraj P, Jawahar M, Banurekha V, Narayanan P. Effect of Vitamin D3 on phagocytic potential of macrophages with live Mycobacterium tuberculosis and lympho proliferative response in pulmonary tuberculosis. J Clin Immunol 2004; 24: 249-57
4. Chan T. Vitamin D deficiency and susceptibility to tuberculosis. Calcif Tissue Int 2000; 66:476-8
5. Chan T, Poon P, Pang J. A study of the calcium and Vitamin D metabolism in Chinese patients with pulmonary tuberculosis. J Trop Med Hyg 1994; 97:26-0
6. Khan H. Prevalence of vitamin D deficiency in general population of Islamabad, Pakistan. Ann Pak Inst Med Sci 2013; 9(1):45-7
7. Sheikh A, Saeed Z, Jafri SAD, Yazdani I, Hussain SA. VitaminD levels in asymptomatic adults: a population survey in Karachi, Pakistan PLoS One 2012.7:e33452.
8. World Health Organisation. World tuberculosis report 2012. Geneva: WHO; 2012
9. Liu PT, Stenger S, Tang DH, Modlin RL. Cutting edge: Vitamin D mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol 2007; 179:2060-3.
10. Martineau AR, Wilkinson KA, Newton SM, Floto RA, Norman AW, Skolimowska K, et al. IFN-gamma- and TNF-independent Vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37. J Immunol 2007; 178:7190-98
11. Davies PD, Brown RC, Woodhead JS. Serum concentration of vitamin D metabolites in untreated tuberculosis. Thora 1985; 40:187-90.
12. Davies PD, Brown RC, Woodhead JS. Serum concentrations of vitamin D metabolites in untreated tuberculosis. Thorax 1985; 40:187-90
13. Gibney KB, MacGregor L, Leder K, Torresi J, Marshall C, Ebeling PR, et al. Vitamin D deficiency is associated with tuberculosis and latent tuberculosis infection in immigrants from sub-Saharan Africa. Clin Infect Dis 2008; 46:443-6
14. Rook GAW. The role of Vitamin D in tuberculosis. Am RevRespir Dis 1988; 138:768-70
15. New JP, Middleton RJ, Klebe B, Farmer CK, de Lusignan S,Stevens PE, et al. Assessing the prevalence, monitoring and management of chronic kidney disease in patients with diabetes compared with those without diabetes in general practice. Diabet Med 2007; 24:364-9
16. Khan S. Vitamin D deficiency and secondary hyperparathyroidism among patients with chronic kidney disease. Am J Med Sci 2007; 333:201-07
17. Mansoor S, Habib A, Ghani F, Fatmi Z, Badruddin S, Mansoor S, et al. Prevalence and significance of Vitamin D deficiency and insufficiency among apparently healthy adults. Clin.Biochem 43; 2010:1431-5
18. Ogunkolade WB, Boucher BJ, Bustin SA, Burrin JM, Noonan K. Vitamin D metabolism in peripheral blood mononuclear cells is influenced by chewing ''betel nut'' (Areca catechu) and Vitamin D status. J Clin Endocrinol Metab 2006; 91: 20.2612-7
19. Martineau AR, Wilkinson RJ, Wilkinson KA, Newton SM, Kampmann B, Hall BM, et al. A single dose of Vitamin D enhances immunity to mycobacteria. Am J Respir Crit Care Med 2007; 176:208-13.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Samreen Bugti
Assistant professor, Department of medicine, Bolan medical college/ Bolan medical complex hospital Quetta
Tariq Mehmood
Medicine PGMI/sheikh Khalifa Bin Zayyed al nehan Hospital, Quetta
Tahira
Assistant professor, Department of Medicine, Bolan Medical College/ Bolan Medical Complex Hospital, Quetta
Taqdees Zahra
Assistant Professor Medicine Department, Bolan Medical College/ Bolan Medical Complex Hospital, Quetta