ENHANCING PATIENT SAFETY THROUGH MEDICATION RECONCILIATION IN SMALL HOSPITAL SETTINGS: A PROSPECTIVE ANALYSIS

Main Article Content

Ayesha Erum Hadi
Waheed Ur Rahman
Nijam Uddin Sarkar
Mohamed Afzana Mohamed Ismail
Dr. Shams Ullah
Aksa Alina Joy
Abdullah Tariq

Keywords

Medication Reconciliation, Patient Safety, Patient Discharge, Hospital Pharmacy Service, Pharmaceutical Assistance.

Abstract

Background: Medication reconciliation and discharge advice play crucial roles in identifying and mitigating medicine-related risks, particularly during transitions of care. Despite their significance, the extent of clinical pharmacy involvement in small hospitals remains underexplored.


Objective: To conduct a prospective study assessing medication reconciliation and pharmacy advice provision upon patients' discharge from a small hospital setting.


Methods: A pilot, prospective, descriptive, and exploratory study involved thirty hospitalized patients. Their medication regimens were monitored from admission through discharge, including the matching of medications and provision of pharmaceutical instructions.


Results: The majority of patients were female (57%) with an average age of 71, hospitalized for an average of three days. Pyelonephritis was the primary admission diagnosis (23%), while high blood pressure was the most prevalent comorbidity (60%). Medications predominantly targeted the nervous and circulatory systems (37%). Discrepancies in medication records totalled 100, with 10% intentional changes, primarily through drug substitution (70%), and 90% unintentional, mainly involving omitted medications (98%). 95% of pre-hospitalization drugs were implicated in discrepancies, with the coronary system most affected (42%). Documentation gaps were noted in medical records regarding patients' comorbidities, with omissions observed in both physician (50%) and nursing (25%) entries. The discharge medication list only accounted for 43% of administered drugs. Therapeutic discrepancies were prevalent, mainly due to unintentional omissions, highlighting the risk of medication omission during transitions of care.


Conclusion: Medication reconciliation and discharge advice play pivotal roles in enhancing patient safety during transitions of care. However, the study underscores significant gaps in clinical pharmacy involvement and documentation practices in small hospital settings, emphasizing the need for improved strategies to ensure medication safety and continuity of care.

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References

1. Al Musawi, A., Hellström, L., Axelsson, M., Midlöv, P., Rämgård, M., Cheng, Y., & Eriksson, T. (2024). Intervention for a correct medication list and medication use in older adults: a non-randomized feasibility study among inpatients and residents during care transitions. International Journal of Clinical Pharmacy, 1-9.
2. Avvaru, D., Reddy, M. S., Azar, S., Wali, S., Patil, M. V., Bhandari, R., & Ganachari, M. (2024). Assessment of medication discrepancy, medication appropriateness, and cost analysis among patients with pediatric nephrotic syndrome: An ambispective cohort observational study. Archives de Pédiatrie, 31(2), 106-111.
3. Bailly, R., Wuyts, S., Toelen, L., Mets, T., Van Hauwermeiren, C., Scheerlinck, T., . . . Lieten, S. (2024). Introducing a pharmacist-led transmural care program to reduce drug-related problems in orthogeriatric patients: a prospective interventional study. BMC geriatrics, 24(1), 47.
4. Balaban, U., Kara, E., Pınar, A., Özcebe, O., Demirkan, S., & Ünal, S. Antimicrobial treatments during therapeutic plasma exchange: a questionnaire on practices.
5. Bamgboye, A. O., Hassan, I. A., Fatoye, E. O., Ozuluoha, C. C., Folami, S. O., & Uwizeyimana, T. (2024). We are enhancing the care transition performance of community pharmacies in Nigeria: Health Science Reports, 7(2), e1904.
6. Bormann, T. M., Brower, K. I., & Forshay, C. M. (2024). Implementation of pharmacy-led preoperative medication reconciliation in surgical oncology patients. Journal of the American Pharmacists Association.
7. Butler, T. A., Heiman, E., Bianco, J., Blanco, D., Carris, N. W., & Martinez, A. (2024). Evaluation of pharmacist impact on multidisciplinary transitions of care service in Bundled Payments for Care Improvement Advanced model patients. Journal of the American College of Clinical Pharmacy, 7(1), 15-24.
8. Canning, M. L., Barras, M., McDougall, R., Yerkovich, S., Coombes, I., Sullivan, C., & Whitfield, K. (2024). Defining quality indicators, pharmaceutical care bundles and outcomes of clinical pharmacy service delivery using a Delphi consensus approach. International Journal of Clinical Pharmacy, 1-12.
9. Chandran, M. M., Cohen, E., Doligalski, C. T., Bowman, L. J., Kaiser, T. E., & Taber, D. J. (2024). The measure of impact: Proposal of quality metrics for solid organ transplant pharmacy practice. American Journal of Transplantation, 24(2), 164-176.
10. de Oliveira, A. M., Romeiro, B. F., Rodrigues, J. P. V., Varallo, F. R., & Leira Pereira, L. R. (2024). Empowerment Provided by Health Education and its Impact on Self-care: Report of a Pharmaceutical Intervention. Current Drug Therapy, 19(1), 116-121.
11. Farajallah, A. A., Zainal, H., & Palaian, S. (2024). Medication reconciliation practices in Gulf Cooperation Council countries: A review. Journal of Applied Pharmaceutical Science, 14(2), 061-072.
12. Fentie, A. M., Huluka, S. A., Gebremariam, G. T., Gebretekle, G. B., Abebe, E., & Fenta, T. G. (2024). Impact of pharmacist-led interventions on medication-related problems among patients treated for cancer: A systematic review and meta-analysis of randomized control trials. Research in Social and Administrative Pharmacy.
13. Gormley, L., Mullins, C., & Sylvia, L. M. (2024). Implementation of a Synergistic, Complementary Pharmacy Practice Model for an Advanced Heart Failure/Heart Transplant Program. Journal of Pharmacy Practice, 37(1), 17-26.
14. Hahn, B., Ball, T., Diab, W., Choi, C., Bleau, H., & Flynn, A. (2024). Utilization of a multidisciplinary hospital-based approach to reduce readmission rates. SAGE Open Medicine, 12, 20503121241226591.
15. Henman, M. C., Ravera, S., & Lery, F.-X. (2024). Council of Europe Resolution on the Implementation of Pharmaceutical Care—A Step Forward in Enhancing the Appropriate Use of Medicines and Patient-Centred Care. Paper presented at the Healthcare.
16. Hernandez, T., Barisano, D., Welsh, C., Rosano, J., & Papiro, T. (2024). Development of a Discharge Counseling and Medication Reconciliation Process for Pediatric Patients Within a Large, Academic Health System. The Journal of Pediatric Pharmacology and Therapeutics, 29(1), 76-81.
17. Hoffman, A. M., Walls, J. L., Prusch, A., & Roberts, J. (2024). It prevented harm and cost avoidance with pharmacist intervention while utilizing a discharge medication reconciliation tool—American Journal of Health-System Pharmacy, 81(1), e37-e44.
18. Jackson, A. B., Lewis, M., Meek, R., Kim-Blackmore, J., Khan, I., Deng, Y., . . . Egerton-Warburton, D. (2024). Regular Medications in the Emergency Department Short Stay Unit (ReMedIES): Can Prescribing be Improved Without Increasing Resources? Hospital Pharmacy, 59(1), 110-117.
19. Khartabil, N., Haghparast, P., Al‐Chokachi, Z., & Clemens, E. (2024). The impact of pharmacists on medication safety in mental health: A narrative review. Journal of the American College of Clinical Pharmacy.
20. Lee, K. M. K., Koeper, I., Johnson, M. E., Page, A., Rowett, D., & Johnson, J. (2024). Multidisciplinary perspectives on roles of hospital pharmacists in tertiary settings: a qualitative study. International Journal for Quality in Health Care, 36(1), mzad110.
21. Lekpittaya, N., Kocharoen, S., Angkanavisul, J., Siriudompas, T., Montakantikul, P., & Paiboonvong, T. (2024). Drug-related problems identified by clinical pharmacists in an academic medical centre in Thailand. Journal of Pharmaceutical Policy and Practice, 17(1), 2288603.
22. Leung, C. K., Walton, N. C., Kheder, E., Zalpour, A., Wang, J., Zavgorodnyaya, D., . . . Bruera, E. (2024). Understanding Potentially Preventable 7-day Readmission Rates in Hospital Medicine Patients at a Comprehensive Cancer Center. American Journal of Medical Quality, 39(1), 14-20.
23. Liang, M.-Y., Feng, L., Zhu, W., & Yang, Q.-Q. (2024). Effect of frailty on medication deviation during the hospital-family transition period in older patients with cardiovascular disease: An observational study. Medicine, 103(2), e36893.
24. Lias, N., Lindholm, T., Holmström, A.-R., Uusitalo, M., Kvarnström, K., Toivo, T., . . . Airaksinen, M. (2024). Harmonizing the definition of medication reviews for their collaborative implementation and documentation in electronic patient records: A Delphi consensus study. Research in Social and Administrative Pharmacy.
25. Loh, C. (2024). The prevalence and preventability of medication-related readmissions after bariatric surgery: an interim analysis.
26. Mahomedradja, R. F., Tichelaar, J., Mokkink, L. B., Sigaloff, K. C., & van Agtmael, M. A. (2024). Quality indicators for appropriate in‐hospital pharmacotherapeutic stewardship: An international modified Delphi study. British journal of clinical pharmacology.
27. Mills, W. R., Howard, S., Pitzen, K., Smitherman, J., Cole, L., Wolfram, J., . . . Poltavski, D. (2024). A Novel Home-Based Medication Management Program and Its Influence on Hospitalization Rates among Home Health Care Recipients. Journal of the American Medical Directors Association, 25(1), 155-157. e151.
28. Moshman, R., Martirosyan, D., & Sibblis, J. (2024). Improving Education On Discharge For Patients Admitted With Heart Failure. Journal of Cardiac Failure, 30(1), 165.
29. Mundell, R., Jamieson, D., Shaw, G., Thomson, A., & Forsyth, P. (2024). Patient Experiences of Community Pharmacy Medication Supply and Medicines Reconciliation at Hospital Discharge: A Qualitative Study.
30. Ndai, A. M., Morris, E. J., Winterstein, A. G., & Vouri, S. M. (2024). Evaluating Provider and Pharmacy Discordance in Potential Calcium Channel Blocker–Loop Diuretic Prescribing Cascade. Drugs & Aging, 1-10.
31. Očovská, Z., Procházková, J., Maříková, M., & Vlček, J. (2024). Renal drug dosage adjustments and adverse drug events in patients with chronic kidney disease admitted to the hospital: a cross-sectional study. Expert Opinion on Drug Safety, 1-11.
32. Ojo, S., Okoye, T. O., Olaniyi, S. A., Ofochukwu, V. C., Obi, M. O., Nwokolo, A. S., . . . Obodo, O. R. (2024). Ensuring Continuity of Care: Effective Strategies for the Post-hospitalization Transition of Psychiatric Patients in a Family Medicine Outpatient Clinic. Cureus, 16(1).
33. Pitman, S. K., Clouse, A., Hiner, M., & So, J. (2024). Admission medication history quality: Considering nonprescription medications, limited English proficiency, and medication history sources. American Journal of Health-System Pharmacy, 81(1), e45-e48.
34. Prasad, N., Lau, E. C., Wojt, I., Penm, J., Dai, Z., & Tan, E. C. (2024). Prevalence of and Risk Factors for Drug-Related Readmissions in Older Adults: A Systematic Review and Meta-Analysis. Drugs & Aging, 41(1), 1-11.
35. Promraj, R., Susomboon, T., Tovikkai, C., & Kositamongkol, P. (2024). We are improving Patient Safety in Medication Management through Medication Reconciliation and Pharmaceutical Care Process in the Post-Liver Transplant Clinic—paper presented in the Transplantation Proceedings.
36. Rahuel, C., Pautrat, M., Aïdoud, A., Fougère, B., & Debacq, C. (2024). Providing information about medication changes upon discharge from a geriatric unit: the community healthcare professionals' point of view. BMC geriatrics, 24(1), 39.
37. Rangchian, M., Makhdoumi, M., Zamanirafe, M., Parvaneh, E., Eshraghi, A., Entezari-Maleki, T., & Mehrpooya, M. (2024). Impact of Clinical Pharmacist-conducted Medication Reconciliation at Admission and Discharge on Medication Safety in Patients Hospitalized with Acute Decompensated Heart Failure. Current Drug Safety.
38. Rhoten, B., Jones, A. C., Maxwell, C., & Stolldorf, D. P. (2024). Hospital Adaptions to Mitigate the COVID-19 Pandemic Effects on MARQUIS Toolkit Implementation and Sustainability. The Journal for Healthcare Quality (JHQ), 46(1), 1-11.
39. Sellers, K., Wright, A., Wallace, C., & Nieuwstraten, C. Quantifying Clinical Pharmacy Key Performance Indicators (cpKPIs) at St. Joseph's Healthcare Hamilton (SJHH) using a Standardized Documentation Approach: A Quality Improvement Initiative.
40. Sheth, S., Bialostozky, M., Hollenbach, K., Heitzman, L., O’Crump, D., Mishra, S., . . . Billman, G. (2024). Standardizing Medication Reconciliation in a Pediatric Emergency Department. Pediatrics, 153(2).
41. Szwak, J. A., Assadi, R. A., Gonzalez, J., Hong, L. T., Meyenburg, L. K., Miesner, A. R., . . . Fritz, M. K. (2024). Nationwide evaluation of the clinical impact of acute care adult medicine pharmacists. Journal of the American College of Clinical Pharmacy.
42. Tasseff, N., Axtell, S., & Nixon, B. (2024). Effect of extended pharmacist involvement in discharge transitions of care on hospital readmission rates: Prospective, randomized, parallel-arm design trial. Journal of the American College of Clinical Pharmacy, 7(1), 8-14.
43. Treadwell, J. R., Jepson, C., Ivlev, I., & Reston, J. T. (2024). Reducing Adverse Drug Events Related to Anticoagulant Use in Adults Making Healthcare Safer IV: A Continuous Updating of Patient Safety Harms and Practices [Internet]: Agency for Healthcare Research and Quality (US).
44. Yamamoto, M. (2024). Improving Medication Safety Through Medication Reconciliation in Ambulatory Care. Azusa Pacific University.

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