POLY-PHARMACYAND DRUG INTERACTIONS IN PATIENTS WITH COEXISTING DIABETES MELLITUS AND SYSTEMIC ARTERIAL HYPERTENSION

Main Article Content

Dr. Rebecca Caruana
Dr. Muhammad Furqan
Dr. Anurag rawat
Majid.Ali
Dr. Shanullah
Ehitzaz Afsar

Keywords

Diabetes Mellitus, Systemic Arterial Hypertension, Antihypertensives, Hypoglycemics

Abstract

Objective: This study aims to identify and report potential drug interactions (DIs) in the prescriptions of patients with both Systemic Arterial Hypertension (SAH) and Diabetes Mellitus (DM) receiving treatment at Mayo Hospital Lahore Hospital Lahore. The focus is on understanding the impact of poly-pharmacy on the occurrence of drug interactions.


 


Methods: The research involved the analysis of 50 medical records from patients with coexisting SAH and DM. Participants who did not provide data on the studied variables were excluded from the analysis. The relationship between poly-pharmacy and the development of drug interactions was systematically examined. The study sheds light on the association between the quantity of prescribed drugs and the frequency of interactions.


 


Results: Poly-pharmacy emerged as the predominant risk factor for the occurrence of drug interactions in patients with both SAH and DM. The research findings highlight a significant relationship between poly-pharmacy and the development of drug interactions, indicating that an increase in the number of prescribed drugs correlates with a higher frequency of interactions. The study emphasizes the need for further research, advocating for well-designed, randomized studies to enhance the understanding of diagnosis, treatment, and prevention in this patient population.


 


Conclusion: This research underscores the critical role of poly-pharmacy in contributing to potential drug interactions among patients with SAH and DM. The identified association between the quantity of prescribed drugs and the frequency of interactions necessitates a more comprehensive understanding of medication management. The study advocates for future randomized research initiatives to enhance the precision of protocols and improve the overall quality of life for individuals with coexisting SAH and DM.


Objective: This study aims to identify and report potential drug interactions (DIs) in the prescriptions of patients with both Systemic Arterial Hypertension (SAH) and Diabetes Mellitus (DM) receiving treatment at Mayo Hospital Lahore Hospital Lahore. The focus is on understanding the impact of poly-pharmacy on the occurrence of drug interactions.


 


Methods: The research involved the analysis of 50 medical records from patients with coexisting SAH and DM. Participants who did not provide data on the studied variables were excluded from the analysis. The relationship between poly-pharmacy and the development of drug interactions was systematically examined. The study sheds light on the association between the quantity of prescribed drugs and the frequency of interactions.


 


Results: Poly-pharmacy emerged as the predominant risk factor for the occurrence of drug interactions in patients with both SAH and DM. The research findings highlight a significant relationship between poly-pharmacy and the development of drug interactions, indicating that an increase in the number of prescribed drugs correlates with a higher frequency of interactions. The study emphasizes the need for further research, advocating for well-designed, randomized studies to enhance the understanding of diagnosis, treatment, and prevention in this patient population.


 


Conclusion: This research underscores the critical role of poly-pharmacy in contributing to potential drug interactions among patients with SAH and DM. The identified association between the quantity of prescribed drugs and the frequency of interactions necessitates a more comprehensive understanding of medication management. The study advocates for future randomized research initiatives to enhance the precision of protocols and improve the overall quality of life for individuals with coexisting SAH and DM.

Abstract 375 | pdf Downloads 106

References

Older Adults: Standards of Care in Diabetes—2024. (2024). Diabetes Care, 47(Supplement_1), S244-S257.
2. Ali, M., Shoaib, M. H., Nesar, S., Jamal, M., Gul, S., Shahnaz, S., . . . Imran, J. (2024). A prospective observational study of estimating drug related problems and clinical outcomes in subtypes of stroke patients. PLoS ONE, 19(1), e0295208.
3. Almalki, Z. S., Imam, M. T., Ahmed, N. J., Ghanem, R. K., Alanazi, T. S., Juweria, S., . . . Hasino, F. H. (2024). The influence of telemedicine in primary healthcare on diabetes mellitus control and treatment adherence in Riyadh region. Saudi Pharmaceutical Journal, 32(1), 101920.
4. Benetos, A. (2024). Hypertension in older people. In hypertension (pp. 518-527): Elsevier.
5. Bullock, J. E. (2024). Provider adherence to American Diabetes Association cardiovascular risk–reduction guidelines: An integrative review. Journal of the American Association of Nurse Practitioners, 36(1), 17-22.
6. Chang, H.-Y., Wu, H.-W., Hung, C.-S., Chen, Y.-H., Huang, C.-C., Yang, L.-T., . . . Ho, Y.-L. (2024). Costs and Cardiovascular Benefits of a Fourth-Generation Synchronous Telehealth Program on Mortality and Cardiovascular Outcomes for Patients With Atrial Fibrillation: Retrospective Cohort Study. Journal of Medical Internet Research, 26(1), e48748.
7. Charchar, F. J., Prestes, P. R., Mills, C., Ching, S. M., Neupane, D., Marques, F. Z., . . . Korostovtseva, L. (2024). Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension. Journal of hypertension, 42(1), 23-49.
8. Chen, Y.-T., Lin, C.-C., Huang, P.-H., & Li, S.-Y. (2024). Comparative analysis of hemodialysis and peritoneal dialysis on the risk of new onset diabetes mellitus. Journal of the Formosan Medical Association.
9. Eshiet, U. I., Igwe, C. N., & Ogbeche, A. O. (2024). Comparative assessment of medication knowledge among ambulatory patients: A cross-sectional study in Nigeria. Exploratory Research in Clinical and Social Pharmacy, 13, 100388.
10. Fedorowski, A., Fanciulli, A., Raj, S. R., Sheldon, R., Shibao, C. A., & Sutton, R. (2024). Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden. Nature Reviews Cardiology, 1-17.
11. Giannella, A. D., Cavaiola, T. S., & Kulasa, K. (2024). Inpatient Type 1 Diabetes. In Diabetes Management in Hospitalized Patients: A Comprehensive Clinical Guide (pp. 51-63): Springer.
12. Hsu, H.-F., Lo, K.-Y., Yeh, Y.-P., Chen, T. H.-H., & Luh, D.-L. (2024). Do abnormal screening results for chronic diseases motivate inactive people to start exercising? A community-based prospective cohort study in Changhua, Taiwan. Preventive Medicine, 107860.
13. Huang, M., Yang, L., Zhang, C., & Gan, X. (2024). Glucose management in critically ill adults: A qualitative study from the experiences of health care providers. Heliyon.
14. Jaber, D., Al Shihab, A., & Tamimi, L. N. (2024). Efficacy and Safety of Pharmacist-Managed NSAIDs Deprescribing: A Jordanian Outpatient Study. Journal of Clinical Pharmacy and Therapeutics, 2024.
15. Joglar, J. A., Chung, M. K., Armbruster, A. L., Benjamin, E. J., Chyou, J. Y., Cronin, E. M., . . . Gopinathannair, R. (2024). 2023 ACC/AHA/ACCP/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation, 149(1), e1-e156.
16. Keller, M. S., Qureshi, N., Mays, A. M., Sarkisian, C. A., & Pevnick, J. M. (2024). Cumulative Update of a Systematic Overview Evaluating Interventions Addressing Poly-pharmacy. JAMA Network Open, 7(1), e2350963-e2350963.
17. Klopotowska, J. E., Leopold, J. H., Bakker, T., Yasrebi‐de Kom, I., Engelaer, F. M., de Jonge, E., . . . Jong, B. T. (2024). Adverse drug events caused by three high‐risk drug–drug interactions in patients admitted to intensive care units: A multicentre retrospective observational study. British journal of clinical pharmacology.
18. Leszczak, J., Czenczek-Lewandowska, E., Asif, M., Baran, J., Mazur, A., & Wyszyńska, J. (2024). Risk factors and prevalence of hypertension in older adults from south-eastern Poland: an observational study. Scientific Reports, 14(1), 1450.
19. Mallamaci, F., & Tripepi, G. (2024). Risk Factors of Chronic Kidney Disease Progression: Between Old and New Concepts. Journal of Clinical Medicine, 13(3), 678.
20. Martins, A., Vitorino, J., Maia, E., & Praça, I. Pharmitech: Addressing Poly-pharmacy Challenges Through Ai-Driven Solutions. Available at SSRN 4668688.
21. Mellot, M., Jawal, L., Morel, T., Fournier, J.-P., Tubach, F., Cadwallader, J.-S., . . . Zerah, L. (2024). Barriers and Enablers for Deprescribing Glucose-Lowering Treatment in Older Adults: A Systematic Review. Journal of the American Medical Directors Association.
22. Mohajan, D., & Mohajan, H. K. (2024). Oral Hypoglycaemic Agents: Non-Insulin Medications for Type 2 Diabetes Patients. Innovation in Science and Technology, 3(1), 23-31.
23. Nelson, A. J., Pagidipati, N. J., & Bosworth, H. B. (2024). Improving medication adherence in cardiovascular disease. Nature Reviews Cardiology, 1-13.
24. Niriayo, Y. L., Kifle, R., Asgedom, S. W., & Gidey, K. (2024). Drug therapy problems among hospitalized patients with cardiovascular disease. BMC Cardiovascular Disorders, 24(1), 50.
25. Palomo-Piñón, S., Enciso-Muñoz, J. M., Meaney, E., Díaz-Domínguez, E., Cardona-Muller, D., Pérez, F. P., . . . Antonio-Villa, N. E. (2024). Strategies to prevent, diagnose and treat kidney disease related to systemic arterial hypertension: a narrative review from the Mexican Group of Experts on Arterial Hypertension. BMC nephrology, 25(1), 1-17.
26. Quesada-Caballero, M., Carmona-García, A., García-Lara, R. A., Caballero-Mateos, A. M., Suleiman-Martos, N., Cañadas-De la Fuente, G. A., & Romero-Béjar, J. L. (2024). Assessing the Risk of Hypertension in Chronic, Elderly Patients during the COVID-19 Pandemic: A Prospective Study. Journal of Cardiovascular Development and Disease, 11(1), 21.
27. Ramani, S., Bahuguna, M., Spencer, J., Pathak, S., Shende, S., Pantvaidya, S., . . . Jayaraman, A. (2024). Many hops, many stops: care-seeking “loops” for diabetes and hypertension in three urban informal settlements in the Mumbai Metropolitan Region. Frontiers in Public Health, 11, 1257226.
28. Ramsingh, N., Lin, H. M., Ouyang, Y., Ravona‐Springer, R., Livny, A., Soleimani, L., . . . Sano, M. (2024). Poor self‐rated health is associated with faster cognitive decline and greater small vessel disease in older adults with type 2 diabetes. Diabetes/Metabolism Research and Reviews, 40(1), e3761.
29. Reimers Wessberg, M. (2024). Aspects on heart failure and drug treatment in geriatric patients.
30. Smith, C., Sarteau, A. C., Qu, X., Noe, V., Young, L. A., Lich, K. H., & Kahkoska, A. R. (2024). A conceptual model of the continuous glucose monitoring integration process for older adults with diabetes developed using participatory systems science methods. Diabetes Research and Clinical Practice, 207, 111053.
31. Søgaard, M., Jensen, M., Højen, A. A., Larsen, T. B., Lip, G. Y., Ording, A. G., & Nielsen, P. B. (2024). Net Clinical Benefit of Oral Anticoagulation Among Frail Patients With Atrial Fibrillation: Nationwide Cohort Study. Stroke, 55(2), 413-422.
32. Srinivas, V., Choubey, U., Kapparath, S., Shaik, T., Singh, B., Mahmood, R., . . . Jain, R. (2024). Age-Related Orthostatic Hypotension: A Comprehensive Analysis of Prevalence, Mechanisms, and Management in the Geriatric Population. Cardiology in Review, 10.1097.
33. Trolle Lagerros, Y., Grotta, A., Freyland, S., Grannas, D., & Andersson, D. P. (2024). Risk of death in patients with coronary artery disease taking nitrates and phosphodiesterase-5 inhibitors. Journal of the American College of Cardiology, 83(3), 417-426.
34. Ulgu, M. M., Erturkmen, G. B. L., Yuksel, M., Namli, T., Postacı, Ş., Gencturk, M., . . . Dogac, A. (2024). A Nationwide Chronic Disease Management Solution via Clinical Decision Support Services: Software Development and Real-Life Implementation Report. JMIR Medical Informatics, 12(1), e49986.
35. Valitabar, N., Esmaily, H., Sistanizad, M., Roshanzamiri, S., Farrokhian, A., & Mohammadnezhad, G. (2024). Drug-Related Problems and Clinical Pharmacist-Led Medication Therapy Management; Three-Year Survey in an Educational Pharmacotherapy Clinic.
36. Wang, C., Zhang, H., Wang, F., Guo, J., Yuan, J., Hou, G., . . . Health, M. P. S. G. o. S. (2024). Efficacy and safety of PDE5 inhibitors in middle-aged and old patients with and without hypogonadism. The Aging Male, 27(1), 2288347.
37. Wang, S., Jiang, Q., Lou, Y., You, Q., & Cao, S. (2024). Association of social isolation and loneliness with the risk of hypertension in middle aged and older adults: Findings from a national representative longitudinal survey. Journal of Affective Disorders.
38. Wu, Y.-W., Wang, C.-Y., Cheng, N.-C., Lin, H.-J., Huang, H.-L., Huang, J.-H., . . . Hsu, P.-C. (2024). 2024 TSOC/TSPS Joint Consensus: Strategies for Advanced Vascular Wound Management in Arterial and Venous Diseases. Acta Cardiologica Sinica, 40(1), 1.
39. Wyss, F., Barrios, V., Méndez, M., Ramos, S., Gonzalez, Á., Ortiz, H., . . . Franco, C. E. (2024). Central American and Caribbean Consensus Document for the Optimal Management of Oral Anticoagulation in Patients with Non-Valvular Atrial Fibrillation Endorsed by the Central American and Caribbean Society of Arterial Hypertension and Cardiovascular Prevention. Journal of Clinical Medicine, 13(2), 314.
40. Yu, Y., Wang, S., & You, L. (2024). Understanding the Integrated Health Management System Policy in China From Multiple Perspectives: Systematic Review and Content Analysis. Journal of Medical Internet Research, 26, e47197.
41. ZENG, S., YANG, R., DENG, X., YANG, R., & YANG, X. (2024). Management Standards of Poly-pharmacy in Type 2 Diabetes Combined with Atherosclerotic Cardiovascular Diseases in the Elderly. Chinese General Practice, 27(05), 597.

Most read articles by the same author(s)