NUTRITIONAL INTERVENTIONS FOR MALE REPRODUCTIVE HEALTH: A COMPREHENSIVE REVIEW ON THE IMPACT OF ALMONDS, WALNUTS, AND CASHEW NUTS

Main Article Content

Muhammad Hamza
Ghulam Fatima
Ayesha Khalid
Shameen Hashmi
Maria Javaid
Ahsan Zubair
Waleed Fahad Alhujaili
Iqra Rasheed

Keywords

Males Infertility, Reproductive Disorders, Almonds and Fertility, Walnuts and Fertility, Cashew Nuts and Fertility, Sperm Quality

Abstract

Objective: This review aims to investigate the potential impact of dietary interventions involving almonds, walnuts, and cashew nuts on preventing reproductive disorders and improving fertility in males.


Methodology: A thorough literature search was conducted across scientific databases, including Google Scholar, PubMed, and Web of Science, to identify relevant studies published up to the present date. Keywords such as "male fertility," "reproductive disorders," "almonds," "walnuts," and "cashew nuts" were used to filter articles. Studies focusing on the effects of these nuts on male reproductive parameters, including sperm quality, hormone levels, and overall reproductive health, were included in this review.


Results: Almonds, walnuts and cashew nuts have been found to contain a variety of bioactive compounds, including vitamin E, folate, zinc, copper, omega-3 fatty acids, and polyphenols that are associated with improved sperm productions, quality and protect sperms against oxidative stress, which can prevent the damage of sperm DNA and improves fertility. Additionally, these nuts may contribute to the reduction of inflammation, which is also a known contributor to reproductive disorders and infertility in males.


Conclusion: The present reviewed literature suggests a potential link between the consumption of almonds, walnuts, cashew nuts and improved male reproductive health. However, further well-designed clinical studies are needed to establish causal relationships and determine optimal dietary patterns. Including these nuts as part of a balanced and nutritious diet may offer a holistic approach to prevent reproductive disorders and enhance fertility in males.

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References

1. Skakkebaek, N. E., Rajpert-De Meyts, E., Buck Louis, G. M., Toppari, J., Andersson, A. M., Eisenberg, M. L., ... & Juul, A. (2016). Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility. Physiological reviews, 96(1), 55-97.
2. World Health Organization. (2013). Health topics: infertility. Geneva (Switzerland): Department of Reproductive Health and Research, WHO.
3. Obeagu, E. I., Njar, V. E., & Obeagu, G. U. (2023). Infertility: Prevalence and consequences. Int. J. Curr. Res. Chem. Pharm. Sci, 10(7), 43-50.
4. Agarwal, A., Mulgund, A., Hamada, A., & Chyatte, M. R. (2015). A unique view on male infertility around the globe. Reproductive biology and endocrinology, 13(1), 1-9.
5. Qi, X., Wang, K., Zhou, G., Xu, Z., Yu, J., & Zhang, W. (2016). The role of testicular artery in laparoscopic varicocelectomy: a systematic review and meta-analysis. International Urology and Nephrology, 48, 955-965.
6. Babakhanzadeh, E., Nazari, M., Ghasemifar, S., & Khodadadian, A. (2020). Some of the factors involved in male infertility: a prospective review. International journal of general medicine, 29-41.
7. Cui, C., Wang, L., & Wang, X. (2021). Effects of self-esteem on the associations between infertility-related stress and psychological distress among infertile chinese women: a cross-sectional study. Psychology Research and Behavior Management, 1245-1255.
8. Sharma, A. (2017). Male infertility; evidences, risk factors, causes, diagnosis and management in human. Ann Clin Lab Res, 5(3), 188.
9. Krausz, C., & Riera-Escamilla, A. (2018). Genetics of male infertility. Nature Reviews Urology, 15(6), 369-384.
10. Mahdi, M. A., Shwish, D. L., & Almhmdi, N. A. (2018). Evaluation of the impact of the level of (Testosterone, Luteinizing Hormone, Follicle-Stimulating Hormone and Prolactin) on some semen parameters in infertile males. Tik. J. of Pure Sci., 23(7), 27-31.
11. Alahmar, A., Dutta, S., & Sengupta, P. (2019). Thyroid hormones in male reproduction and infertility. Asian Pacific Journal of Reproduction, 8(5), 203-210.
12. Maggi, M., Buvat, J., Corona, G., Guay, A., & Torres, L. O. (2013). Hormonal causes of male sexual dysfunctions and their management (hyperprolactinemia, thyroid disorders, GH disorders, and DHEA). The journal of sexual medicine, 10(3), 661-677.
13. Comhaire, F. H., Mahmoud, A. M. A., Depuydt, C. E., Zalata, A. A., & Christophe, A. B. (1999). Mechanisms and effects of male genital tract infection on sperm quality and fertilizing potential: the andrologist's viewpoint. Human Reproduction Update, 5(5), 393-398.
14. Punjani, N., & Lamb, D. J. (2020). Male infertility and genitourinary birth defects: there is more than meets the eye. Fertility and Sterility, 114(2), 209-218.
15. Sajjad, A., Akhtar, M. A., & Sajjad, Y. (2018). Pathologies of the Male Reproductive Tract. Clinical Reproductive Science, 159.
16. Urinalysis, P. E. (2017). Non-obstructive Diseases of the Testes. Atlas of Imaging in Infertility: A Complete Guide Based in Key Images, 161.
17. Skoracka, K., Eder, P., Łykowska-Szuber, L., Dobrowolska, A., & Krela-Kaźmierczak, I. (2020). Diet and nutritional factors in male (in) fertility—underestimated factors. Journal of clinical medicine, 9(5), 1400.
18. Ahmed-Farid, O. A., Nasr, M., Ahmed, R. F., & Bakeer, R. M. (2017). Beneficial effects of curcumin nano-emulsion on spermatogenesis and reproductive performance in male rats under protein deficient diet model: Enhancement of sperm motility, conservancy of testicular tissue integrity, cell energy and seminal plasma amino acids content. Journal of Biomedical Science, 24(1), 1-14.
19. Pascoal, G. D. F. L., Geraldi, M. V., Maróstica Jr, M. R., & Ong, T. P. (2022). Effect of paternal diet on spermatogenesis and offspring health: focus on epigenetics and interventions with food bioactive compounds. Nutrients, 14(10), 2150.
20. Salas‐Huetos, A., Maghsoumi‐Norouzabad, L., James, E. R., Carrell, D. T., Aston, K. I., Jenkins, T. G., ... & Salas‐Salvadó, J. (2021). Male adiposity, sperm parameters and reproductive hormones: An updated systematic review and collaborative meta‐analysis. Obesity Reviews, 22(1), e13082.
21. Du Plessis, S. S., Cabler, S., McAlister, D. A., Sabanegh, E., & Agarwal, A. (2010). The effect of obesity on sperm disorders and male infertility. Nature Reviews Urology, 7(3), 153-161.
22. Sermondade, N., Faure, C., Fezeu, L., Shayeb, A. G., Bonde, J. P., Jensen, T. K., ... & Czernichow, S. (2013). BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis. Human reproduction update, 19(3), 221-231.
23. Ferramosca, A., & Zara, V. (2022). Diet and male fertility: The impact of nutrients and antioxidants on sperm energetic metabolism. International journal of molecular sciences, 23(5), 2542.
24. Salas-Huetos, A., Bulló, M., & Salas-Salvadó, J. (2017). Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies. Human reproduction update, 23(4), 371-389.
25. Swan, S. H., Kruse, R. L., Liu, F., Barr, D. B., Drobnis, E. Z., Redmon, J. B., ... & Study for Future Families Research Group. (2003). Semen quality in relation to biomarkers of pesticide exposure. Environmental health perspectives, 111(12), 1478-1484.
26. Meeker, J. D., Calafat, A. M., & Hauser, R. (2009). Urinary metabolites of di (2‐ethylhexyl) phthalate are associated with decreased steroid hormone levels in adult men. Journal of andrology, 30(3), 287-297.
27. Bansal, A. K., & Cheema, R. S. (2019). Role of Life Style Factors in Male Reproductive Functions: A Review. Theriogenology Insight-An International Journal of Reproduction in all Animals, 9(3), 111-116.
28. El Hawary, S. S., Sokkar, N. M., El Halawany, A. M., & Mokbel, H. A. (2014). Study of nutritional contents of Prunus amygdalus Batsch seeds. The Egyptian Journal of Hospital Medicine, 57(October), 437-443.
29. United States Department of Agriculture (USDA). (2021). Basic Report: 12061, Nuts, almonds. Retrieved from https://fdc.nal.usda.gov/fdc-app.html#/food-details/171970/nutrients
30. Dikmen, D. (2015). Sert kabuklu kuruyemişler ve sağlık üzerine etkileri. Beslenme ve Diyet Dergisi, 43(2), 174-182.
31. Kırca, L., & Karadeniz, T. (2022). Chemical composition of almond fruit. Fruits for human use in various aspects.
32. Dehghani Bidgoli, R. (2019). Vegetarian food recommendation in the traditional Islamic teachings to increase the fertility of men. Journal of Ethnic Foods, 6, 1-7.
33. Adebayo, A. A., Oboh, G., & Ademosun, A. O. (2021). Effect of dietary inclusion of almond fruit on sexual behavior, arginase activity, pro‐inflammatory, and oxidative stress markers in diabetic male rats. Journal of food biochemistry, 45(3), e13269.
34. Salas-Huetos, A., Moraleda, R., Giardina, S., Anton, E., Blanco, J., Salas-Salvadó, J., & Bulló, M. (2018). Effect of nut consumption on semen quality and functionality in healthy men consuming a Western-style diet: a randomized controlled trial. The American journal of clinical nutrition, 108(5), 953-962.
35. REHMAN, I., AHMAD, A., WASEEM, N., SHABBIR, F., GILL, M., RASUL, A., & ASHFAQ, M. (2021). Effect of Almonds and Atenolol on Sperm Morphology in male Balb-C Mice. Pakistan Journal of Medical and Health Sciences, 15(4), 699-702.
36. Agarwal, A., Nandipati, K. C., Sharma, R. K., Zippe, C. D., & Raina, R. (2005). Role of oxidative stress in pathophysiology of erectile dysfunction. J Androl, 27, 335-347.
37. Adebayo, A. A., Oboh, G., & Ademosun, A. O. (2022). Nutraceutical potential of almond fruits in managing diabetes‐related erectile dysfunction: Effect on Nrf‐2 level and smooth muscle/collagen ratio. Andrologia, 54(11), e14636.
38. Ali, M., Ullah, A., Ullah, H., Khan, F., Ibrahim, S. M., Ali, L., & Ahmad, S. (2010). Fruit properties and nutritional composition of some walnut cultivars grown in Pakistan. Pakistan Journal of Nutrition, 9(3), 240-244.
39. Ghorbani, R., Mokhtari, T., Khazaei, M., Salahshoor, M. R., Jalili, C., & Bakhtiari, M. (2014). The Effect of Walnut on the Weight, Blood Glucose and Sex Hormones of Diabetic Male Rats. International Journal of Morphology, 32(3).
40. Robbins, W. A., Xun, L., FitzGerald, L. Z., Esguerra, S., Henning, S. M., & Carpenter, C. L. (2012). Walnuts improve semen quality in men consuming a Western-style diet: randomized control dietary intervention trial. Biology of reproduction, 87(4), 101-1.
41. Masterson, J. M., Kim, H. H., & Robbins, W. A. (2020). Walnuts improve semen quality in infertile men: a randomized control dietary intervention trial. Fertility and Sterility, 114(3), e23-e24.
42. Ikwuka, D. C., Anyaehie, B. U., Nwobodo, E., Umegbolu, E. I., & Nworgu, C. C. (2021). Ameliorative effects of African walnut on nicotine-induced reproductive toxicity in rat model. International Journal of Health Sciences, 15(1), 3.
43. Bostani, M., Aqababa, H., Hosseini, S. E., & Ashtiyani, S. C. (2014). A study on the effects of walnut oil on plasma levels of testosterone pre and post puberty in male rats. American Journal of Ethnomedicine, 1(4), 266-275.
44. Nair, K. P., & Nair, K. P. (2021). Cashew nut (Anacardium occidentale L.). Tree Crops: Harvesting Cash from the World's Important Cash Crops, 27-77.
45. Ahmed, U., & Birnin-Yauri, U. A. (2008). Comparative analysis of the nutrient composition of cashew (Anacardium occidentale) apple and nut.
46. Karikari, A. A., Anim-Jnr, A. S., Sarfo, G. K., Hamidu, J. A., & Osei, S. A. Effects of partial replacement of maize with cashew kernel meal on the growth and reproductive performance of layer pullets and semen characteristics of cockerels.
47. Akomolafe, S. F., Aina, B., Bajulaye, J., Ogundare, I., Olulade, D., Adeniji, R., ... & Asogwa, N. T. (2021). Modulatory effect of cashew (Anacardium occidentale L.) nut supplemented diet on fertility activity of clomiphene citrate in male rats. biomedical journal, 44(2), 190-200.
48. Omobolanle, A. F., Olaoye, I. M., Olaolu, K. N., Adebayo, L. I., Ademola, B. S., Adedoyin, A. D., ... & Lydia, A. A. (2023). Anacardium occidentale Methanolic Nut Extract Attenuated Testicular Dysfunctions in High-fat Diet and Streptozotocin-Induced Diabetic Male Wistar Rats. Journal of Applied Pharmaceutical Sciences and Research, 6(1), 16.

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