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Sana Fatima
Ayesha Khalid
Ammar Ijaz
Asna Tauqeer
Muneeb Abid
Ayesha Farooq
Sabila Ali
Iqra Rasheed
Zohaib Ahmed
Rida Rana


Vitamin B6, Anxiety, Depression, Vitamin B12. Neural influences.


Background: In the metabolic processes, the Vitamin B complex including B6 and B12 play a vital role like increasing the neural inhibition and decrease excitation.

Objective:  The objective of this study is to analyze the effect of essential vitamin, vitamin B And its association it’s like logical disorders like anxiety and depression.

Data source: The database of Google scholar and PubMed were searched for relevant articles.

Materials and Methods: This review article examines the impact of the high dose supplementation of vitamin B6 and B12 on various behavioral parameters like the balance between the inhibition and excitation of the neurons. In addition to this, it also showed inhibitory function that acted as various sensory measures. These included battery of tactile sensitivity, rate of binocular rivalry reversal, and detection of visual contrast.

Results: The results of the double-blind study suggest that high-dose supplementation of Vitamin B6 enhanced the neural influences i.e. inhibitory GABAergic. This inhibitory neural influence is known for its production of GABA.

Conclusion: The vitamin B6 supplementation started a trend towards decreasing depression and the reduction of self-reported anxiety. The supplementation also enhanced the visual contrast detection’s suppression. But, on other outcome measures, this supplementation had no reliable impact. Also, the vitamin B12 supplementation, induced a pattern towards visual processing and changes in anxiety.

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