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Anand R Hiremath
Roshan. S


R.rosea. INH+RF, Liver injury and CAT


Rhodiola rosea has been used as food and folk medicine to recover several diseases. In the present study were evaluated effect of ethanolic extract of R.rosea on Isoniazid and Rifampicin induced liver injury on rats. Isoniazid and Rifampicin was administered a 100 and 50 mg/kg bw dose to induced hepatotoxicity. R.rosea (400 and 600mg/kg, p.o ) and Silymarin 100mg/kg, p.o. were administered once daily for 28 days. The liver injury was estimated by liver function function parameters ALP,AST,ALT,TP andTB. Oxidative stress markers GSH, MPO,MDA,SOD CAT as well histopathology of liver. Isoniazid and Rifampicin drugs significantly reduction in liver weight,  increases in serum liver  biochemical, decreses in Oxidative stress and changes in histopathology of liver. Treatment with R.rosea in a dose depended manner significantly changing in weight liver, liver function estimation , lipid peroxidation and histopathology of liver compare to control and Silymarin group. The present studies evidence that the ethanolic extract of R.rosea has shown hepatoprotective activity

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