EFFECT OF SCAPHIUM AFFINE ON FORCED SWIMMING TEST AND COLD STRESS INDUCED ULCER IN RATS
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Keywords
S. affine Cold stress, Ulcer, IL-6, IL-8andTNF-α
Abstract
The present study was carried out to evaluate the effect of ethanolic fruit extract of Scaphium affine on swimming endurance test and cold stress induced Ulcer in albino rats. The effect was assessed by swimming survival time, estimation of ulcer index, PH of gastric juice, biochemical parameters like Glucose, Cholesterol, Triglycerides, Plasma cortisol and Blood urea nitrogen (BUN) oxidative marker MDA, MPO, serum nitrate content, SOD and GSH content and pro inflammatory cytokines IL-6, IL-8 and TNF -α and histopathology of stomach at a dose of 300 and 500 mg/kg (per oral) were determined. S. affine extract significantly (p<0.001) increases swimming time, decrease in blood glucose, cholesterol, triglyceride, cortisol and BUN. Significant (p<0.01) decrease in ulcer index and increase PH of gastric juice was observed compared to control group, Increased in SOD, GSH, CAT and NO decrease in MPO and MDA contents, pro inflammatory cytokines IL-6, IL-8 andTNF-α significantly decrease and histopathology of stomach restore to normal compare to control, this obtained results revealed that the extract of S. affine has significant anti stress and anti ulcer activity in rats
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Lakshmana V Bendre
Research Scholar, Department of Pharmacy, Bir Tikendrajit University, Imphal, Manipur
Contact number :+91- 9008603508
Roshan. S
Research Supervisor, Department of Pharmacy, Bir Tikendrajit University, Imphal, Manipur