PHYTOCHEMICAL AND PHARMACOLOGICAL SCREENING OF MOMORDICA DIOICA FOR HEPATOPROTECTIVE ACTIVITY IN RATS
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Keywords
Isoniazid and Rifampicin, M. dioica and Silymarin
Abstract
The present study was designed to evaluate hepatoprotective activity of Momordica dioica (M. dioica) in Wistar albino rats using Anti Tuberculosis drugs induced hepatic damaged experimental animals. Isoniazid and Rifampicin-induced was administered a 100 and 50 mg/kg bw dose to induce hepatotoxicity. M. dioica (300 and 500mg/kg, p.o ) and Silymarin 100mg/kg, p.o. were administered once daily for 30 days. The degree of hepatoprotection was measured using morphological parameters of changing in weight of liver, Biochemical parameters in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase (SALP), bilirubin. The histopathological parameters of histological changes in the liver architecture like architecture of hepatic lobules, swelling of liver cell, fatty changes, focal necrosis, inflammatory cell infiltration around portal areas, kupffer cell hyperplasia etc. The result of this study indicated that the M. dioica has got a hepatoprotective action against Isoniazid and Rifampicin induced hepatic damage in experimental animals.
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Kowti Rajesh
Research Scholar, Department of Pharmacy, Bir Tikendrajit University, Imphal, Manipur
Contact number :+91- 9886566249
Roshan. S
Research Supervisor, Department of Pharmacy, Bir Tikendrajit University, Imphal, Manipur