ANTI GENOTOXIC ACTIVITY OF LUTEOLIN ON CYCLOPHOSPHAMIDE INDUCED GENOTOXICITY IN ALBINO MICE.
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Keywords
CP, Micronuclei, Luteolin, P/N ratio
Abstract
The present study was designed to investigate the effect of Luteolin on Cyclophosphamide (CP) induced genotoxicity in mice. A dose of Luteolin 40mg/kg was selected for the study, Animals received 30 days pretreatment of Luteolin followed by induction of genotoxicity by CP (40mg/kg) 24 hours before sacrifice of Mice bone marrow micronucleus assay were employed for the study. Results shows the CP induced significantly increased bone micronucleus Polychromatic, Micronucles, Bilobed cells and P/N ratio, however CP decreased Normal cells. Treatment with Luteolin Results showed that a significant increase normal cells, Decreased in Micronuclei (MN) formation in polychromatic erythrocytes of Micronucles, Bilobed cells and P/N ratio. Micronuclei (MN) formation in polychromatic erythrocytes, produced cytotoxicity in mouse bone marrow cells Pretreatments with Luteolin, significantly inhibited cytotoxicity in mouse bone marrow cells induced by CP. Our studies revealed that Luteolin has protective effect against genotoxicity induced by CP.
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Ruksana Syeda
Research Scholar, Mewar University, Chittorgarh, Rajasthan, India.
Roshan. S
Research Supervisor, Mewar University, Chittorgarh, Rajasthan, India