RHODIOLA ROSEA TOPICAL GEL FOR WOUND HEALING ACTIVITY
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Keywords
R.rosea, Zeta potential, SEM, Excision wound.
Abstract
The aim of the present study is formulation and evaluation of Topical gel of R.rosea for its physical properties in-vitro permeation, and excision wound healing activity in rats. Topical gels were prepared by different two polymers Carbopol and Hydroxypropyl Methyl Cellulose(HPMC) (0.5-1.5%). The gels were evaluated for their viscosity, spreadability, content uniformity, In-vitro diffusion of gels using Franz diffusion cell. It was observed that with an increase in the polymer percentage, there was a proportional increase in the viscosity and reduced spreadability. Similarly, the rate of diffusion of the drug from the gels was also reduced with an increase in the polymer concentration. All the prepared formulations demonstrated content uniformity and moderate to good spreadability. Treatment of R.rosea Topical gel on Excision wound significantly decreased wound contraction time and Percentage wound is compare to control group. It concluded that R.rosea loaded Topical gels is a viable option for the treatment of wounds.
References
2. Kurmukov AG, Aizikov MI, Rakhimov SS: Pharmacology of the plant polyphenol epigalokhin. FarmakolToksikol .1986;49: 45–48.
3. Furmanowa M, Skopinska-Rozewska E, Rogala E, Hartwich M: Rhodiola rosea in vitro culture-phytochemical analysis and antioxidant action. Acta Soci Bota Pol. 1998;67: 69–73.
4. Maslov LN, Lishmanov YB, Maimessulova LA, Krashov EA: A mechanism of antiarrhythmic effect of Rhodiola rosea. Bull Exper Biol Med .1998;125: 374–376.
5. Bawa AS, Khanum F. Anti-inflammatory activity of Rhodiolaroseae" a second-generation adaptogen.Phytother Res2009;23:1099e102.
6. Chen TS, Liou SY, Chang YL..Antioxidant evaluation of three adaptogen extracts. Am J Chin Med. 2008;36:1209e17.
7. Skopinska-Rozewska E, Malinowski M, Wasiutynski A, Sommer E, Furmanowa M, Mazurkiewicz M, Siwicki AK.The influence of Rhodiolaquadrifida 50% hydro-alcoholic extract and salidroside on tumor-induced angiogenesis in mice. Pol J Vet Sci; 2008.11:97e104.
8. Syahmi, A.R.M.; Vijayarathna, S.; Sasidharan, S.; Latha, L.Y.; Kwan, Y.P.; Lau, Y.L.; Shin, L.N.; Chen, Y. Acute oral toxicity and brine shrimp lethality of Elaeisguineensis jacq., (oil palm leaf) methanol extract. Molecules ;2010, 15, 8111–8121.
9. Dave V, Kumar D, Lewis S, Paliwal S. Ethosome for enhanced transdermal drug delivery of aceclofenac. Int J Drug Deliv 2011;2:81-92.
10. Misal J, Dixit G, Gulkari V. Formulation and evaluation of herbal gel. Indian J Nat Prod Res 2012;3:501-5.
11. Nasir, M.A.M., N.L. Mahammad, S. Roshan and M.W. Ahmad,. Wound healing activity of poly herbal formulation in albino rats using excision wound model, incision wound model, dead space wound model and burn wound model. Int. J. Res. Deve. Pharm. Life Sci. 2016, 5: 2080-2087.
12. Roshan S., S. Ali, A. Khan, B. Tazneem and M.G. Purohit, Wound healing activity of Abutilon indicum. Pharmacogn. Mag. 2008, 4: 85-88.
13. Sultana, Z., M. Jabeen, P. Sultana, S. Begum and M. Begum et al.,. Pharmacological screening of poly herbal formulation for wound healing activity on albino rats. Int. J. Biol. Pharmaceut. Res. 2015, 6: 554-557.
14. Nayak, B.S., & Pinto Pereira, L.M. Catharanthus roseus flower extract has wound healing activity in Sprague Dawley rats. BMC Complementary and Alternative Medicine, 2006;6, 41–467
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Abdul Razak T K
Research Scholar, Department of Pharmacy, Bir Tikendrajit University, Imphal, Manipur E-mail- Contact number :+91- 8105430386
Roshan. S
Research Supervisor, Department of Pharmacy, Bir Tikendrajit University, Imphal, Manipur