MAGNETIC RESONANCE IMAGING ALTERATION OF THEBRAIN IN APATIENT WITH CORONAVIRUS DISEASE 2019(COVID-19) ANDANOSMIA

Abstract

Magnetic resonance imaging (MRI) is a non-invasive medical imaging technique that uses a strong magnetic field and radio waves to produce detailed images of internal body structures. Recent studies have shown that COVID-19 infection can lead to alterations in brain structure and function, which can be detected using MRI. The main objective of this meta-analysis is to find the magnetic resonance imaging alteration of the brain in a patient with COVID-19 and anosmia. For this study, Preferred Reporting Items guideline for conducting this meta-analysis was followed. Electronic articles from January 2020 to January 2023 were searched on PUB Med, online Willey library, and ScienceDirect site. At the start, the initial symptoms of selected studies were noted. During analysis the main symptoms of Covid infected patients were fever and dry cough, decrease in the count of white blood cells and lymphocyte count, and increase the frequency of C-reactive protein among the affected patients. The meta-analysis may reveal that COVID-19 patients with anosmia have a significantly higher likelihood of experiencing MRI alterations in certain brain regions compared to COVID-19 patients without anosmia. In conclusion, this meta-analysis highlights the consistent magnetic resonance imaging (MRI) alterations observed in COVID-19 patients with anosmia, indicating the potential involvement of the central nervous system (CNS) in COVID-19 pathophysiology. The observed MRI alterations may be related to direct viral invasion, immune-mediated damage, or disruption of the blood-brain barrier.