A COMPREHENSIVE ANALYSIS OF FREQUENCY AND SEVERITY OF HYPONATREMIA IN ISCHEMIC STROKE PATIENTS
Main Article Content
Keywords
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Abstract
1: Introduction
Hyponatremia refers to the serum sodium concentration less than 135-145 mmol/L, which is the normal range [1]. Generally, it is recognised as common electrolyte disturbance observed in clinical setting, especially among stroke patients. Such consideration can have severe implications for stroke patients that complicates the clinical course and impacting outcomes [2]. In wake of this, gaining the frequency and severity of hyponatremia in the population becomes integral to optimise patient management and improve results.
References
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3. Zhongyun Chen, Qingxia Jia, Chunyan Liu Journal of Stroke and Cerebrovascular Diseases 28 (6), 1674-1683, 2019
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5. George Liamis, Fotios Barkas, Efstathia Megapanou, Eliza Christopoulou, Andromachi Makri, Konstantinos Makaritsis, George Ntaios, Moses Elisaf, Haralampos Milionis European Neurology 82 (1-3), 32-40, 2020
6. Sienkiewicz-Jarosz H, et al. (2014) The occurrence of hyponatremia in patients with ischemic stroke. Neurologia i Neurochirurgia Polska48(2):83-87.
7. Chien Huang WY, Weng WC, Peng TI, Chien YY, Wu CL, Lee M, Hung CC, Chen KH. Association of hyponatremia in acute stroke stage with three-year mortality in patients with first-ever ischemic stroke. Cerebrovasc Dis. 201234(1):55-62. doi: 10.1159/000338906. Epub 2012 Jun 29. PMID: 22759703.
8. Eze CO, Afolabi OF, Kalu AU. Prevalence of Hyponatremia in Acute Stroke Patients in a Federal Teaching Hospital, Abakaliki, Nigeria. West Afr J Med. 2022 Nov 3039(11):1188-1192. PMID: 36455196.
9. Chen, Z., Jia, Q. and Liu, C., 2019. Association of hyponatremia and risk of short-and long-term mortality in patients with stroke: a systematic review and meta-analysis. Journal of Stroke and Cerebrovascular Diseases, 28(6), pp.1674-1683.
10. Saleem S, Yousuf I, Gul A, Gupta S, Verma S. Hyponatremia in stroke. Ann Indian Acad Neurol. 2014 Jan17(1):55-7. doi: 10.4103/0972-2327.128554. PMID: 24753660 PMCID: PMC3992770.
11. Ali K, et al. (2016) Hyponatremia in acute ischemic stroke. Journal of the College of Physicians and Surgeons Pakistan26(3):192-195.
12. Ali Z, et al. (2018) Frequency of hyponatremia in acute ischemic stroke. JPMA. The Journal of the Pakistan Medical Association68(9):1339-1342.
13. He, L., Guo, Z.N., Qu, Y. and Jin, H., 2022. Hyponatremia is associated with post-thrombolysis hemorrhagic transformation and poor clinical outcome in ischemic stroke patients. Frontiers in Molecular Neuroscience, 15, p.879863.
14. He L, Guo ZN, Qu Y, Jin H. Hyponatremia Is Associated With Post-thrombolysis Hemorrhagic Transformation and Poor Clinical Outcome in Ischemic Stroke Patients. Front Mol Neurosci. 2022 Jul 1815:879863. doi: 10.3389/fnmol.2022.879863. PMID: 35923753 PMCID: PMC9341483
15. Shima, Shogo, Yasunari Niimi, Yosuke Moteki, Osamu Takahashi, Shinsuke Sato, Tatsuya Inoue, and Yoshikazu Okada. "Prognostic significance of hyponatremia in acute stroke: a systematic review and meta-analysis." Cerebrovascular Diseases 49, no. 5 (2020): 531-539.
16. Chen, Zhongyun, Qingxia Jia, and Chunyan Liu. "Association of hyponatremia and risk of short-and long-term mortality in patients with stroke: a systematic review and meta-analysis." Journal of Stroke and Cerebrovascular Diseases 28, no. 6 (2019): 1674-1683.
17. Karunanandham, Sivakumar, Thamarai Rajappa, and Kalavathy Selvaraju. "Hyponatremia in Patients Admitted with Stroke." Journal of Clinical & Diagnostic Research 12, no. 8 (2018).
18. Liamis, George, Fotios Barkas, Efstathia Megapanou, Eliza Christopoulou, Andromachi Makri, Konstantinos Makaritsis, George Ntaios, Moses Elisaf, and Haralampos Milionis. "Hyponatremia in acute stroke patients: pathophysiology, clinical significance, and management options." European Neurology 82, no. 1-3 (2020): 32-40.
19. Kalita, Jayantee, Rajesh Kumar Singh, and Usha Kant Misra. "Cerebral salt wasting is the most common cause of hyponatremia in stroke." Journal of Stroke and Cerebrovascular Diseases 26, no. 5 (2017): 1026-1032.
20. Rodrigues, Bernardo, Ilene Staff, Gilbert Fortunato, and Louise D. McCullough. "Hyponatremia in the prognosis of acute ischemic stroke." Journal of stroke and Cerebrovascular Diseases 23, no. 5 (2014): 850-854.
21. Ahangar, Alijan Ahmadi, Bahareh Bazuiar, Payam Saadat, Hamed Hosseinzadeh, Roughaie Mortazavinezhad, Sekine Faraji, Samaneh Hosseinalipour, and Shayan Alijanpour. "Hyponatremia And Disability, Prevalence And Prognosis In Babol Stroke Patients." Advances in Biosciences & Clinical Medicine (2017): 11.
22. Soiza, Roy L., Kirsten Cumming, Allan B. Clark, Joao H. Bettencourt-Silva, Anthony K. Metcalf, Kristian M. Bowles, John F. Potter, and Phyo K. Myint. "Hyponatremia predicts mortality after stroke." International Journal of Stroke 10, no. SA100 (2015): 50-55.
23. Shima, Shogo, Yasunari Niimi, Yosuke Moteki, Osamu Takahashi, Shinsuke Sato, Tatsuya Inoue, and Yoshikazu Okada. "Prognostic significance of hyponatremia in acute stroke: a systematic review and meta-analysis." Cerebrovascular Diseases 49, no. 5 (2020): 531-539.
24. Liamis, George, Fotios Barkas, Efstathia Megapanou, Eliza Christopoulou, Andromachi Makri, Konstantinos Makaritsis, George Ntaios, Moses Elisaf, and Haralampos Milionis. "Hyponatremia in acute stroke patients: pathophysiology, clinical significance, and management options." European Neurology 82, no. 1-3 (2020): 32-40.
25. Maniram, R. S., Lalji Patel, and K. K. Kaware. "Hyponatremia in stroke patients and its association with early mortality." Journal of Evolution of Medical and Dental Sciences 4, no. 54 (2015): 9485-9492.
26. Kuramatsu, Joji B., Tobias Bobinger, Bastian Volbers, Dimitre Staykov, Hannes Lücking, Stephan P. Kloska, Martin Köhrmann, and Hagen B. Huttner. "Hyponatremia is an independent predictor of in-hospital mortality in spontaneous intracerebral hemorrhage." Stroke 45, no. 5 (2014): 1285-1291.
27. Barkas, Fotios, Georgia Anastasiou, George Liamis, and Haralampos Milionis. "A step-by-step guide for the diagnosis and management of hyponatraemia in patients with stroke." Therapeutic Advances in Endocrinology and Metabolism 14 (2023): 20420188231163806.
28. Zhang, Xu, and Xiao-Ying Li. "Prevalence of hyponatremia among older inpatients in a general hospital." European Geriatric Medicine 11 (2020): 685-692.
2. Mahesar SA, Memon SF, Mustafa S, Javed A, Butt SM. Evaluation of Hyponatremia in Ischemic Stroke Patients in a Tertiary Care Hospital of Karachi, Pakistan. Cureus. 2019 Jan 2111(1):e3926. doi: 10.7759/cureus.3926. PMID: 30937232 PMCID: PMC6433087.
3. Zhongyun Chen, Qingxia Jia, Chunyan Liu Journal of Stroke and Cerebrovascular Diseases 28 (6), 1674-1683, 2019
4. Shima, S., Niimi, Y., Moteki, Y., Takahashi, O., Sato, S., Inoue, T. and Okada, Y., 2020. Prognostic significance of hyponatremia in acute stroke: a systematic review and meta-analysis. Cerebrovascular Diseases, 49(5), pp.531-539 .
5. George Liamis, Fotios Barkas, Efstathia Megapanou, Eliza Christopoulou, Andromachi Makri, Konstantinos Makaritsis, George Ntaios, Moses Elisaf, Haralampos Milionis European Neurology 82 (1-3), 32-40, 2020
6. Sienkiewicz-Jarosz H, et al. (2014) The occurrence of hyponatremia in patients with ischemic stroke. Neurologia i Neurochirurgia Polska48(2):83-87.
7. Chien Huang WY, Weng WC, Peng TI, Chien YY, Wu CL, Lee M, Hung CC, Chen KH. Association of hyponatremia in acute stroke stage with three-year mortality in patients with first-ever ischemic stroke. Cerebrovasc Dis. 201234(1):55-62. doi: 10.1159/000338906. Epub 2012 Jun 29. PMID: 22759703.
8. Eze CO, Afolabi OF, Kalu AU. Prevalence of Hyponatremia in Acute Stroke Patients in a Federal Teaching Hospital, Abakaliki, Nigeria. West Afr J Med. 2022 Nov 3039(11):1188-1192. PMID: 36455196.
9. Chen, Z., Jia, Q. and Liu, C., 2019. Association of hyponatremia and risk of short-and long-term mortality in patients with stroke: a systematic review and meta-analysis. Journal of Stroke and Cerebrovascular Diseases, 28(6), pp.1674-1683.
10. Saleem S, Yousuf I, Gul A, Gupta S, Verma S. Hyponatremia in stroke. Ann Indian Acad Neurol. 2014 Jan17(1):55-7. doi: 10.4103/0972-2327.128554. PMID: 24753660 PMCID: PMC3992770.
11. Ali K, et al. (2016) Hyponatremia in acute ischemic stroke. Journal of the College of Physicians and Surgeons Pakistan26(3):192-195.
12. Ali Z, et al. (2018) Frequency of hyponatremia in acute ischemic stroke. JPMA. The Journal of the Pakistan Medical Association68(9):1339-1342.
13. He, L., Guo, Z.N., Qu, Y. and Jin, H., 2022. Hyponatremia is associated with post-thrombolysis hemorrhagic transformation and poor clinical outcome in ischemic stroke patients. Frontiers in Molecular Neuroscience, 15, p.879863.
14. He L, Guo ZN, Qu Y, Jin H. Hyponatremia Is Associated With Post-thrombolysis Hemorrhagic Transformation and Poor Clinical Outcome in Ischemic Stroke Patients. Front Mol Neurosci. 2022 Jul 1815:879863. doi: 10.3389/fnmol.2022.879863. PMID: 35923753 PMCID: PMC9341483
15. Shima, Shogo, Yasunari Niimi, Yosuke Moteki, Osamu Takahashi, Shinsuke Sato, Tatsuya Inoue, and Yoshikazu Okada. "Prognostic significance of hyponatremia in acute stroke: a systematic review and meta-analysis." Cerebrovascular Diseases 49, no. 5 (2020): 531-539.
16. Chen, Zhongyun, Qingxia Jia, and Chunyan Liu. "Association of hyponatremia and risk of short-and long-term mortality in patients with stroke: a systematic review and meta-analysis." Journal of Stroke and Cerebrovascular Diseases 28, no. 6 (2019): 1674-1683.
17. Karunanandham, Sivakumar, Thamarai Rajappa, and Kalavathy Selvaraju. "Hyponatremia in Patients Admitted with Stroke." Journal of Clinical & Diagnostic Research 12, no. 8 (2018).
18. Liamis, George, Fotios Barkas, Efstathia Megapanou, Eliza Christopoulou, Andromachi Makri, Konstantinos Makaritsis, George Ntaios, Moses Elisaf, and Haralampos Milionis. "Hyponatremia in acute stroke patients: pathophysiology, clinical significance, and management options." European Neurology 82, no. 1-3 (2020): 32-40.
19. Kalita, Jayantee, Rajesh Kumar Singh, and Usha Kant Misra. "Cerebral salt wasting is the most common cause of hyponatremia in stroke." Journal of Stroke and Cerebrovascular Diseases 26, no. 5 (2017): 1026-1032.
20. Rodrigues, Bernardo, Ilene Staff, Gilbert Fortunato, and Louise D. McCullough. "Hyponatremia in the prognosis of acute ischemic stroke." Journal of stroke and Cerebrovascular Diseases 23, no. 5 (2014): 850-854.
21. Ahangar, Alijan Ahmadi, Bahareh Bazuiar, Payam Saadat, Hamed Hosseinzadeh, Roughaie Mortazavinezhad, Sekine Faraji, Samaneh Hosseinalipour, and Shayan Alijanpour. "Hyponatremia And Disability, Prevalence And Prognosis In Babol Stroke Patients." Advances in Biosciences & Clinical Medicine (2017): 11.
22. Soiza, Roy L., Kirsten Cumming, Allan B. Clark, Joao H. Bettencourt-Silva, Anthony K. Metcalf, Kristian M. Bowles, John F. Potter, and Phyo K. Myint. "Hyponatremia predicts mortality after stroke." International Journal of Stroke 10, no. SA100 (2015): 50-55.
23. Shima, Shogo, Yasunari Niimi, Yosuke Moteki, Osamu Takahashi, Shinsuke Sato, Tatsuya Inoue, and Yoshikazu Okada. "Prognostic significance of hyponatremia in acute stroke: a systematic review and meta-analysis." Cerebrovascular Diseases 49, no. 5 (2020): 531-539.
24. Liamis, George, Fotios Barkas, Efstathia Megapanou, Eliza Christopoulou, Andromachi Makri, Konstantinos Makaritsis, George Ntaios, Moses Elisaf, and Haralampos Milionis. "Hyponatremia in acute stroke patients: pathophysiology, clinical significance, and management options." European Neurology 82, no. 1-3 (2020): 32-40.
25. Maniram, R. S., Lalji Patel, and K. K. Kaware. "Hyponatremia in stroke patients and its association with early mortality." Journal of Evolution of Medical and Dental Sciences 4, no. 54 (2015): 9485-9492.
26. Kuramatsu, Joji B., Tobias Bobinger, Bastian Volbers, Dimitre Staykov, Hannes Lücking, Stephan P. Kloska, Martin Köhrmann, and Hagen B. Huttner. "Hyponatremia is an independent predictor of in-hospital mortality in spontaneous intracerebral hemorrhage." Stroke 45, no. 5 (2014): 1285-1291.
27. Barkas, Fotios, Georgia Anastasiou, George Liamis, and Haralampos Milionis. "A step-by-step guide for the diagnosis and management of hyponatraemia in patients with stroke." Therapeutic Advances in Endocrinology and Metabolism 14 (2023): 20420188231163806.
28. Zhang, Xu, and Xiao-Ying Li. "Prevalence of hyponatremia among older inpatients in a general hospital." European Geriatric Medicine 11 (2020): 685-692.
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Aug 31, 2024
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Dr. Afaq Naeem, Dr. Mujeeb ur Rehman Abid Butt, Adil Saeed, Maryyam Tariq, Maryam Ahmad, & Bilal Qammar. (2024). A COMPREHENSIVE ANALYSIS OF FREQUENCY AND SEVERITY OF HYPONATREMIA IN ISCHEMIC STROKE PATIENTS. Journal of Population Therapeutics and Clinical Pharmacology, 31(8), 1951-1960. https://doi.org/10.53555/bbhen383
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Author Biographies
Dr. Afaq Naeem
Post Graduate Trainee, Shalamar Hospital, Lahore Pakistan.
Dr. Mujeeb ur Rehman Abid Butt
Chair Department of Medicine & Allied, Shalamar Hospital, Lahore Pakistan.
Adil Saeed
Medical Officer, Pakistan Kidney and Liver Institute (PKLI), Lahore Pakistan.
Maryyam Tariq
House Officer, Department of Medicine, Shalamar Hospital, Lahore Pakistan.
Maryam Ahmad
House Officer, Department of Medicine, Shalamar Hospital, Lahore Pakistan.
Bilal Qammar
House Officer, Department of Medicine, Shalamar Hospital, Lahore Pakistan.
How to Cite
Dr. Afaq Naeem, Dr. Mujeeb ur Rehman Abid Butt, Adil Saeed, Maryyam Tariq, Maryam Ahmad, & Bilal Qammar. (2024). A COMPREHENSIVE ANALYSIS OF FREQUENCY AND SEVERITY OF HYPONATREMIA IN ISCHEMIC STROKE PATIENTS. Journal of Population Therapeutics and Clinical Pharmacology, 31(8), 1951-1960. https://doi.org/10.53555/bbhen383