CLINICAL EFFECT OF AMOXICILLIN-CLAVULANATE POTASSIUM COMBINED WITH BUDESONIDE SUSPENSION INHALATION IN THE TREATMENT OF CHILDREN WITH SINUSITIS

Abstract

Objective: To study the clinical efficacy of amoxicillin-clavulanate potassium combined with budesonide suspension inhalation in the treatment of children with sinusitis.

Method: A total of 128 pediatric sinusitis patients admitted to the hospital from December 2018 to April 2020 were selected and divided into two groups according to the order of admission. The control group (n=64) received amoxicillin-clavulanate potassium therapy, and the study group (n=64) received amoxicillin-clavulanate potassium combined with budesonide suspension aerosol inhalation therapy. The improvement of clinical symptoms, curative effect, CT examination results before and after treatment, and adverse reaction rate were evaluated and compared between the two groups. Result：The subjective scores of clinical symptoms of headache, runny nose, nasal congestion and smelly breathing in the research group were lower than those in the control group (P<0.05); the curative effect of the research group was better than that of the control group (P<0.05). There was no significant difference in the result scores (P>0.05); after treatment, the CT examination results in the study group were lower than those in the control group (P<0.05); there was no significant difference in the adverse reaction rates between the two groups (P>0.05).

Conclusion：The application of amoxicillin-clavulanate potassium combined with budesonide suspension aerosol inhalation therapy for children with sinusitis has a synergistic effect and has a greater therapeutic advantage. This can effectively relieve the clinical symptoms of children without significantly increasing adverse reactions, suggesting that the combination of the two drugs is safe and has high clinical application value.