EXPLORING THE POTENTIAL OF SOME MEDICINAL PLANTS FOR THE TREATMENT OF GOUTY ARTHRITIS

Abstract

This in-depth review delves into the complex and historical condition of gout, a form of arthritis recognized since ancient Egypt, with a particular emphasis on its clinical feature, uricemia. The review covers the underlying causes of uricemia, tracing its historical background, and addresses the ongoing challenges in its treatment. It thoroughly explains the physiological impact of gout, highlighting how uric acid crystals form and affect various tissues and organs. The study dissects the triad of factors that contribute to gout, namely purine metabolism, nucleotide turnover, and renal function. Epidemiological data provide insights into age and gender disparities, as well as the prevalence rates of gout. The review also lists the various risk factors for developing gout, including genetic predisposition, hyperuricemia, lifestyle factors, medications, diet, and other specific conditions.

The research methodology involves a comprehensive literature survey using databases such as PubMed, Scopus, Science Direct, and Google Scholar, with an emphasis on clinical studies and Ayurvedic medicinal plants. The review evaluates conventional gout treatments like xanthine oxidase inhibitors, anti-inflammatory drugs, and urate-lowering agents, along with their limitations and potential side effects. Additionally, it explores the therapeutic potential of medicinal plants such as Tribulus Terrestris, Cichorium intybus Linn, Colchicum Autumnale, Curcuma longa Linn, Zingiber officinalis, Boswellia serrata, Withania somnifera, Nigella sativa, Glycyrrhiza glabra, and Trachyspermum Ammi, assessing their medicinal properties, chemical makeup, and anti-inflammatory effects.

In conclusion, the study underscores the potential benefits of integrating medicinal plants into gout management but calls for a cautious and evidence-based approach. The enduring legacy of traditional remedies provides valuable insights; however, the study stresses the importance of rigorous preclinical and clinical research to fully understand the efficacy and safety of plant-based treatments, ensuring their successful incorporation into modern healthcare.