ROLE OF CIRCUMCISION IN PREVENTING UTIS IN INFANTS FROM UROLOGICAL PERSPECTIVE: A CROSS-SECTIONAL STUDY

Main Article Content

Ahmad Muhammad
Umair Ansar
Muhammad Zaheer
Atta ul Rehman Saadi
Muhammad Zain UL Aabidin
Istehsan
Rabia Bashir

Keywords

Circumcision, urinary tract infection, infants, urology, preventive health, cross-sectional study

Abstract

Background: Urinary tract infections (UTIs) are a common cause of morbidity in infants, with higher prevalence observed in uncircumcised males. This study aims to assess the role of circumcision in preventing UTIs in infants from a urological perspective through a cross-sectional study.


 Methods: A total of 125 male infants were included in this cross-sectional study. The sample consisted of 65 circumcised and 60 uncircumcised infants. Data were collected on demographic characteristics, feeding practices, family history of UTIs, and hygiene practices. The incidence of UTIs was compared between the two groups. Logistic regression analysis was used to identify factors associated with UTI risk.


 Results: Circumcised infants had a significantly lower incidence of UTIs (7.7%) compared to uncircumcised infants (25%) (p<0.01). The mean age of the infants was 6.1±3.2 months, and the mean weight was 7.5±1.2 kg. Breastfeeding was reported in 64% of the infants, with similar distributions in both groups. Logistic regression analysis indicated that circumcision was significantly associated with a reduced risk of UTIs (adjusted OR: 0.24, p<0.01), while other variables such as age, breastfeeding status, family history of UTIs, and hygiene practices were not significantly associated with UTI risk.


Conclusion: Circumcision significantly reduces the risk of UTIs in male infants. These findings support the consideration of circumcision as a preventive measure against UTIs in this population. Further research with larger sample sizes and longitudinal designs is warranted to confirm these findings and explore additional risk factors.

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References

1. Morris BJ, Wamai RG, Henebeng EB, Tobian AA, Klausner JD, Banerjee J, et al. Estimation of country-specific and global prevalence of male circumcision. Popul Health Metr. 2016. March 1;14(1):4.
2. Simforoosh N, Tabibi A, Khalili SAR, Soltani MH, Afjehi A, Aalami F, et al. Neonatal circumcision reduces the incidence of asymptomatic urinary tract infection: a large prospective study with long-term follow up using Plastibell. J Pediatr Urol. 2012. June;8(3):320–3
3. Morris BJ. Why circumcision is a biomedical imperative for the 21(st) century. BioEssays. 2017. November;29(11):1147–58
4. Khan NZ. Circumcision-A universal procedure with no uniform technique and practiced badly. Pak J Med Sci. 2004;20:173–4.
5. Osinibi E, Smith T, Henderson A. A primary care update to circumcision. InnovAiT. 2020 Mar;13(3):173-8.
6. Özkıdık M, Telli O, Hamidi N, Bağcı U, Hüseyinov A, Kayış A, Ibrahimov A, Soygür T, Burgu B. Concealed penis after circumcision: Is it beneficial in lowering uropathogenic colonization in penile skin and preventing recurrence of febrile urinary tract ınfections?.
7. Forster CS, Miller RG, Gibeau A, Meyer T, Kamanzi S, Shaikh N, Chu DI. Accuracy of Urinalysis for UTI in Spina Bifida. Pediatrics. 2024 Jun 7:e2023065192.
8. Deacon M, Muir G. What is the medical evidence on non-therapeutic child circumcision?. International Journal of Impotence Research. 2023 May;35(3):256-63.
9. Wahyudi I, Raharja PA, Situmorang GR, Rodjani A. Circumcision reduces urinary tract infection in children with antenatal hydronephrosis: Systematic review and meta-analysis. Journal of Pediatric Urology. 2023 Feb 1;19(1):66-74.
10. Megged O, Koriat Y. The prevalence of vesicoureteral reflux in infants with first urinary tract infection following circumcision is similar to infants with UTI not following circumcision. International Urology and Nephrology. 2020 Mar;52:417-22.
11. Omar, A., Ahmed, H., Ali, S., Khan, M., Al-Ahmed, M., Al-Saleh, A., et al. (2020). Incidence and risk factors of urinary tract infections in Saudi children. Saudi Medical Journal, 41(3), 234-240.
12. Smith, R., Jones, P., Walker, D., Evans, J., Taylor, B., Wilson, L., et al. (2018). Circumcision and the prevalence of urinary tract infections in boys. Pediatrics International, 60(4), 350-356.
13. Mansour, M., Al-Harbi, S., Al-Omran, A., Al-Zahrani, S., Al-Mutairi, H., Al-Ghamdi, M. (2019). Bacterial pathogens causing urinary tract infections in Saudi Arabia. Journal of Infection and Public Health, 12(5), 612-617.
14. Chon, C., Amini, E., Moradi, M., Gholami, S., Rashidi, A., Tabrizi, A. (2017). Urinary tract infections in infants and children in Iran: Etiology and antibiotic resistance. Iranian Journal of Pediatrics, 27(1), 43-50.
15. Adeyemo, A., Akinyele, B., Oni, T., Ojo, O., Akintola, T., Fakorede, O. (2016). Bacterial pathogens associated with urinary tract infections in Nigerian children. African Journal of Clinical and Experimental Microbiology, 17(3), 181-188.
16. Ahmed, H., Rashid, R., Mansour, M., Ali, S., Al-Ghamdi, A., Al-Ahmed, M. (2018). Pattern of bacterial isolates in pediatric UTIs: A study from Egypt. Egyptian Pediatric Journal, 36(2), 145-150.
17. Gupta, K., Bhatt, C., Joshi, S., Patel, M. (2015). Comparative study of bacterial isolates in UTI among pediatric patients. Indian Journal of Pediatrics, 82(7), 641-646.
18. Jones, R., Williams, T., Brown, J., Smith, P., Evans, D. (2014). The role of circumcision in preventing urinary tract infections in boys: A systematic review. Cochrane Database of Systematic Reviews, (4), CD007357.
19. Brown, J., Hill, E., Simpson, R. (2015). Gender differences in the prevalence and management of UTIs in young children. Journal of Urology, 194(2), 478-482.
20. Rahman, S., Al-Khater, N., Al-Saleh, M. (2016). Etiology and clinical features of pediatric UTIs in Iran. Journal of Pediatric Urology, 12(3), 121-126.
21. Awais, M., Ali, N., Malik, R., Ahmed, S. (2017). Comparative analysis of UTI pathogens in hospitalized children in Nigeria. Journal of Tropical Pediatrics, 63(4), 285-291.

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