PREVALENCE OF THROMBOCYTOPENIA AND ITS IMPACT ON MORTALITY AMONG NEONATES WITH NEONATAL SEPSIS
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Keywords
Neonatal sepsis, thrombocytopenia, neonatal mortality, neonatal intensive care, Escherichia coli, Staphylococcus aureus, Group B Streptococcus, Klebsiella species
Abstract
Background: Neonatal sepsis is a leading cause of morbidity and mortality in newborns, often complicated by thrombocytopenia. Understanding the prevalence of thrombocytopenia and its impact on neonatal outcomes is crucial for improving management and survival rates.
Objective: This study aims to determine the prevalence of thrombocytopenia among neonates with sepsis and assess its impact on in-hospital mortality.
Methods: We conducted a retrospective cohort study of 150 neonates diagnosed with sepsis in the neonatal intensive care unit (NICU) at Shaikh Zayed Hospital, Lahore. Data on demographic characteristics, clinical features, isolated pathogens, and outcomes were collected from electronic medical records. Thrombocytopenia was defined as a platelet count <150,000/µL. Logistic regression was used to analyze the association between thrombocytopenia and mortality, adjusting for potential confounders.
Results: The mean gestational age of the neonates was 32.5 ± 3.2 weeks, and the mean birth weight was 1.8 ± 0.5 kg. Thrombocytopenia was present in 80% of the neonates. The most common pathogens isolated were Escherichia coli (30%), Staphylococcus aureus (25%), and Streptococcus (20%), and Klebsiella species (15%). In-hospital mortality was significantly higher in neonates with thrombocytopenia (20.8%) compared to those without (3.3%). Logistic regression analysis showed that thrombocytopenia was significantly associated with increased in-hospital mortality (adjusted odds ratio: 4.2; 95% CI: 1.5-12.0; p=0.007).
Conclusion: Thrombocytopenia is highly prevalent among neonates with sepsis and is associated with a significantly increased risk of in-hospital mortality. These findings highlight the importance of early detection and management of thrombocytopenia in improving outcomes for neonates with sepsis.
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Atta ul Rehman Saadi
MBBS, Medical Officer, Khalida Memorial Hospital, Sialkot
Rabia Bashir
MBBS, RMP, Medical Graduate from Mohtarma Benazir Bhutto Shaheed Medical College Mirpur AJK
Muhammad Shoaib
MBBS, Medical Officer at Bahria International Hospital Orchard, Lahore
Sattra Sehar
(MBBS Ex House Officer at Sheikh Zaid Hospital, Lahore
Muhammad Zain UL Aabidin
Senior House Officer (SHO), A&E, Shaikh Zayed Hospital Lahore
Shehryar Haider
MBBS, House Officer Anesthesia Shaikh Zayed Hospital, Lahore