ASSOCIATION OF COAGULATION DYSFUNCTION WITH CARDIAC INJURY IN HOSPITALIZED PATIENTS WITH COVID-19

Main Article Content

Muizz Zahoor
Muhammad Shoaib
Saiqa Zahoor
Gul Rukh
Hafsa Tariq
Hamid Mahabat Khan

Keywords

COVID-19, Cardiac Injury, Coagulation Dysfunction

Abstract

Objective: To determine the association of coagulation dysfunction with cardiac injury in hospitalized patients with COVID-19.


Study Design: Descriptive Cross Sectional.


Place and Duration of Study: Department of Hematology, MTI-HayatabadMedical Complex, Peshawar, from Jun 2021 to Dec 2021.


Methodology: A total of 103 patients hospitalized for COVID-19 were included in this study. The sample size was calculated by WHO Sample Size calculator with 7.20% proportion of cardiac injury in hospitalized COVID-19 patients, 5% margin of error and 5% significance level. Cardiac and coagulation biomarkers were recorded at the time of admission and later during hospitalization. To establish association between coagulation dysfunction and cardiac injury, spearman correlation coefficient was used.


Results: Mean age of patients was 57.6+12.36 years. Mean d-dimer was 2.022+2.84 ug/mL, mean fibrin levels were 34.27+54.68 mg/dL and mean fibrinogen was 2.51+1.04 g/L, mean hsTn1 was 5.88+6.51 pg/mL, mean myohemoglobin was 65.49+52.2 ng/mL and mean CK-MB was 16.76+6.67 U/L. Cardiac injury was recorded in 23 (22.3%) patients hospitalized due to COVID-19.


Conclusion: This study demonstrated a significant association of coagulation dysfunction with the development of cardiac injury as markers of coagulation function were found significantly synchronized with the dynamic progression of cardiac biomarkers.

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