ICU ANTIBIOTIC THERAPY DYNAMICS: EXAMINING EXTENDED-SPECTRUM ANTIBIOTICS FROM ADMISSION TO DISCHARGE
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Keywords
Extended-spectrum antibiotics, ICU, monotherapy, combination therapy, prospective study
Abstract
This prospective observational study investigates antibiotic prescription patterns among 460 Intensive Care Unit (ICU) patients in Karachi, Pakistan, with a specific focus on extended-spectrum antibiotics. The study analyzes data from the first to the last day of admission, exploring mono and combination antibiotic therapies and their association with extended-spectrum regimens. The findings reveal dynamic shifts in antibiotic utilization, with a notable decrease in combination therapies over the ICU stay. Examining the extended-spectrum antibiotic, the study identifies a significant increase in monotherapy on the last day of admission. This reflects a potential refinement in antibiotic choices as patients progress through their ICU stay. Notably, the association analysis highlights a significant link between extended-spectrum antibiotics and the choice between mono and combination therapy on the last day, emphasizing the evolving nature of antibiotic decision-making in critical care settings. The results underscore the importance of ongoing monitoring and adaptation of antibiotic regimens based on clinical responses and microbial data. The study contributes valuable insights for antibiotic stewardship in the ICU, emphasizing the need for regular reassessment and adjustment of treatment plans. While acknowledging study limitations, including its prospective nature, these findings provide a foundation for future research aimed at optimizing antibiotic use and improving patient outcomes in critical care settings.
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Sidra Zubair
Lecturer, Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan
Subia Jamil
Professor, Head of the Department, Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women. Karachi, Pakistan
Sakina Fatima
Assistant Professor, Department of Pharmaceutics, Institute of Pharmaceutical Science, Jinnah Sindh Medical University, Karachi, Pakistan
Hira Afshan
Lecturer and Researcher, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan
Sana Waqar
Lecturer, Institute of Pharmaceutical Science, Jinnah Sindh Medical University, Karachi, Pakistan
Mahrukh Khurshid
Lecturer, Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan
Zarnab Mary Augustine
Manager Pharmacy and Store SMBB institute of trauma, Karachi, Pakistan
Maham Maqsood
Pharmacist, Germany