AGE-STRATIFIED ANALYSIS OF ANTIBIOTIC PRESCRIBING PRACTICES: A COMPREHENSIVE STUDY ON EXTENDED-SPECTRUM ANTIBIOTICS IN ICU WITH APACHE IV SCORING
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Abstract
This prospective study delves into the complex antibiotic prescribing practices, focusing on the distribution of extended-spectrum antibiotics in ICU within various age categories and their association with the severity of illness assessed by the APACHE IV scoring system. Analyzing data from ICU admitted patients, distinct age-related patterns was observed, age below 50 categories exhibiting the highest percentage of extended-spectrum antibiotic prescriptions. Correlation with APACHE IV scores revealed a strategic alignment of antibiotic choices with illness severity. Statistical analyses such as Chi-square test, fisher’s exact test (p > 0.005) confirmed a significant association between age categories and extended-spectrum antibiotic use. While these findings provide valuable clinical insights, the study's limitations, including potential biases and short-term perspectives, necessitate careful consideration. In conclusion, this research contributes to a nuanced understanding of antibiotic prescribing, highlighting the need for age-specific and severity-basis approaches in clinical settings
References
2. Wojcik G, Ring N, McCulloch C, Willis DS, Williams B, & Kydonaki K. Understanding the Complexities of Antibiotic Prescribing Behaviour in Acute Hospitals: A Systematic Review and Meta-Ethnography. Archives of Public Health. 2021;79(1):1-19.
3. Borek AJ, Pouwels KB, van Hecke O, Robotham JV, Butler CC, & Tonkin-Crine S. Role of Locum Gps in Antibiotic Prescribing and Stewardship: A Mixed-Methods Study. British Journal of General Practice. 2022;72(715):e118-e27.
4. Nikolich-Žugich J, Bradshaw CM, Uhrlaub JL, & Watanabe M. Immunity to Acute Virus Infections with Advanced Age. Current opinion in virology. 2021;46:45-58.
5. Kramer AA, Zimmerman JE, & Knaus WA. Severity of Illness and Predictive Models in Society of Critical Care Medicine’s First 50 Years: A Tale of Concord and Conflict. Critical Care Medicine. 2021;49(5):728-40.
6. Luo Y, Wang Z, & Wang C. Improvement of Apache Ii Score System for Disease Severity Based on Xgboost Algorithm. BMC Medical Informatics and Decision Making. 2021;21(1):1-12.
7. Mirzakhani F, Sadoughi F, Hatami M, & Amirabadizadeh A. Which Model Is Superior in Predicting Icu Survival: Artificial Intelligence Versus Conventional Approaches. BMC Medical Informatics and Decision Making. 2022;22(1):1-13.
8. Gutiérrez-Gutiérrez B, Pérez-Nadales E, Pérez-Galera S, Fernández-Ruiz M, Carratalà J, Oriol I, et al. Propensity Score and Desirability of Outcome Ranking Analysis of Ertapenem for Treatment of Nonsevere Bacteremic Urinary Tract Infections Due to Extended-Spectrum-Beta-Lactamase-Producing Enterobacterales in Kidney Transplant Recipients. Antimicrobial agents and chemotherapy. 2021;65(11):10.1128/aac. 01102-21.
9. Rhee C, Kadri SS, Dekker JP, Danner RL, Chen H-C, Fram D, et al. Prevalence of Antibiotic-Resistant Pathogens in Culture-Proven Sepsis and Outcomes Associated with Inadequate and Broad-Spectrum Empiric Antibiotic Use. JAMA Network Open. 2020;3(4):e202899-e.
10. Song M, Liu Y, Huang X, Ding S, Wang Y, Shen J, et al. A Broad-Spectrum Antibiotic Adjuvant Reverses Multidrug-Resistant Gram-Negative Pathogens. Nature Microbiology. 2020;5(8):1040-50.
11. Zubair S, Jamil S, Fatima S, Sibtain ST, Nawab A, Khurshid M, et al. Evaluation of Severity, Antibiotic Prescribing Patterns, and Outcomes of Sepsis in the Icu Using the Apache-Iv Scale. Journal of Hunan University Natural Sciences. 2023;50(8).
12. Biswas S, Dasgupta S, Bhowmick MM, Gupta S, Sinha S, Ghosh S, et al. Impact of Appropriate Antibiotics within One Hour and Patients' Outcome: A Study and Review. International Journal of Clinical Nephrology. 2023;5(2).
13. Larcher R, Maury C, Faivre G, Dagod G, Dumont Y, Le Moing V, et al. Acquisition of Extended-Spectrum Cephalosporin-Resistant Gram-Negative Bacteria: Epidemiology and Risk Factors in a 6-Year Cohort of 507 Severe Trauma Patients. Journal of Global Antimicrobial Resistance. 2022;31:363-70.
14. Li A, & Bergan RC. Clinical Trial Design: Past, Present, and Future in the Context of Big Data and Precision Medicine. Cancer. 2020;126(22):4838-46.
15. Lenze EJ, Nicol GE, Barbour DL, Kannampallil T, Wong AW, Piccirillo J, et al. Precision Clinical Trials: A Framework for Getting to Precision Medicine for Neurobehavioural Disorders. Journal of Psychiatry and Neuroscience. 2021;46(1):E97-E110.
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Sidra Zubair
Lecturer, Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan
Subia Jamil
Professor, Head of the Department, Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women. Karachi, Pakistan
Sakina Fatima
Assistant Professor, Department of Pharmaceutics, Institute of Pharmaceutical Science, Jinnah Sindh Medical University, Karachi, Pakistan
Sana Waqar
Lecturer, Institute of Pharmaceutical Science, Jinnah Sindh Medical University, Karachi, Pakistan
Hira Raees
Lecturer, Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan
Asma Eraj
Lecturer, Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan
Mahrukh Khurshid
Lecturer, Department of Pharmacology, Faculty of Pharmacy, Jinnah University for Women, Karachi, Pakistan
Zarnab Mary Augustine
Manager Pharmacy and Store SMBB institute of trauma, Karachi, Pakistan