LIQUORICE AS A NATURAL SUNSCREEN: A COMPRHENSIVE REVIEW

Main Article Content

Divy Patel.
Vaidehi Gurjar
Dr.Pragnesh Patani

Keywords

Cosmeceutical, Natural plant extracts, Cosmetic formulations, Glycyrrhiza genus, Flavonoids, Skin-whitening, Anti-aging, Sun protection, Hair care, Acne management, Licochalcone A, Glabridin, Dehydroglyasperin C, Licorice, Sunscreen, UV protection, Anti-inflammatory, Antioxidan Eco-friendly, Skin health.

Abstract

The use of natural plant extracts and compounds in cosmetics is gaining popularity.


These natural ingredients not only enhance the performance of cosmetics but also offer therapeutic benefits, known as cosmeceutical effects. The Glycyrrhiza genus, found in various regions worldwide and comprising over 30 species, is of particular interest. The roots and rhizomes of these plants are traditionally used in pharmaceuticals, functional foods, and supplements. Recently, there has been a growing interest in utilizing Glycyrrhiza extracts in cosmetic formulations, primarily for their skin-whitening properties.The beneficial effects of Glycyrrhiza extracts in cosmetics are largely attributed to specific compounds from the flavonoid class. This review focuses on the botany and chemistry of the main Glycyrrhiza species, such as G. glabra, G. uralensis, and G. inflata. It also explores their cosmeceutical benefits, including anti-aging, sun protection, hair care, and acne management. Within Glycyrrhiza extracts, three key flavonoids, namely licochalcone A, glabridin, and dehydroglyasperin C, have been extensively studied for their cosmetic effects.


 


Additionally, there are other promising molecules in licorice that may have valuable cosmeceutical properties. These findings suggest the need for further research to fully uncover their potential contributions to the cosmetics industry.This This review article examines how liquorice, a traditional herb from India, can be a valuable addition to sun protection products. Liquorice has garnered attention for its impressive natural sun-blocking properties, thanks to its strong anti-inflammatory, antioxidant, and UV-absorption qualities. This article takes a deep dive into the scientific evidence supporting liquorice's effectiveness in safeguarding the skin against harmful UV rays, reducing sun-related damage, and slowing down the aging process. Additionally, we explore the obstacles and advantages of incorporating liquorice into sunscreen formulations and emphasize its potential as an eco-friendly and skin-friendly substitute for synthetic UV filters. In summary, this comprehensive review provides valuable insights into how liquorice can play a promising role in improving sun protection and maintaining healthy skin[2].

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References

1. Ding Y, Brand E, Wang W, Zhao Z. Liquorice: Resources, applications in ancient and modern times. J Ethnopharmacol. Nov 2022 15;298-306.
2. Giulia pastorino, Laura cornora, Sonia soares. Liquorice: A phytochemical & pharmacological review. Phytother res. Dec, 2018; 32(12) 2323-2339.
3. Shadma Wahab, Sivakumar Annadurai et al. Liquorice: a comprehensive review on its phytochemistry & biological activity, clinical evidence & toxicology, PMC Dec 2021;10(12) 2751-2763.
4. Dheeraj bhatt, Mohhamad rashid, Rajeshwar kamal kant arya, Deepak kumar, Sushil Kumar Chaudhary et al. Revisiting liquorice as anti-inflammatory, antivirals and immunomodulators: Potential pharmacological applications with mechanistic insight. phytomedicine plus, feb 2022; 2(1) 100206-100212.
5. Lim, T.K. Glycyrrhiza glabra. In Edible Medicinal and Non-Medicinal Plants; Springer: Dordrecht, The Netherlands, 2016; Volume 10, pp. 354–457.
6. Song-Yi Yang, Yu-Ri Choi, Myung-Jin Lee, Min-Kyung Kang. Antimicrobial Effects against Oral Pathogens and Cytotoxicity of Glycyrrhiza uralensis Extract. Plants 2020, 9 (7) , 838-846.
7. Lin Zhang, Chen-xiang Wang, Jing Wu, Tian-Yun Wang, Qiao-Qiao Zhong,et al. Metabolic proSling of mice plasma, bile, urine and feces after oral administration of two licorice javonones. Journal of Ethnopharmacology 2020, 257-266.
8. Fiore, C.; Eisenhut, M.; Ragazzi, E.; Zanchin, G.; Armanini, D. A history of the therapeutic use of liquorice in Europe. J. Ethnopharmacol. 2005, 99, 317–324.
9. Ali EM (2013) Phytochemical composition, antifungal, antiaflatoxigenic, antioxidant, and anticancer activities of Glycyrrhiza glabra L. and Matricaria chamomilla L. essential oils. J Med Plants Res 7(29):2197–2207
10. Al-Qarawi AA, Abdel-Rahman HA, Ali BH, El Mougy SA (2002) Liquorice (Glycyrrhiza glabra) and the adrenal-kidney-pituitary axis in rats. Food Chem Toxicol 40(10):1525–1527
11. Hayashi, H.; Yokoshima, K.; Chiba, R.; Fujii, I.; Fattokhov, I.; Saidov, M. Field survey of Glycyrrhiza plants in Central Asia (5). Chemical characterization of G. bucharica Collected in Tajikistan. Chem. Pharm. Bull. 2019, 67, 534–539.
12. Kang, M.R.; Park, K.H.; Oh, S.J.; Yun, J.; Lee, C.W.; Lee, M.Y.; Han, S.-B.; Kang, J.S. Cardiovascular protective effect of glabridin: Implications in LDL oxidation and inflammation. Int. Immunopharmacol. 2015, 29, 914–918.
13. Ashraf, A.; Ashraf, M.M.; Rafiqe, A.; Aslam, B.; Galani, S.; Zafar, S.; Asad, F.; Asghar, R.D.; Akram, S.; Ahmed, H.; et al. In vivo antiviral potential of Glycyrrhiza glabra extract against Newcastle disease virus. Pak. J. Pharm. Sci. 2017, 30, 567–572.
14. lagawany, M.; Elnesr, S.S.; Farag, M.R. Use of liquorice (Glycyrrhiza glabra) in poultry nutrition: Global impacts on performance, carcass and meat quality. World’s Poult. Sci. J. 2019, 1–11.
15. Pastorino, G.; Cornara, L.; Soares, S.; Rodrigues, F.; Oliveira, M.B.P.P. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytother. Res. 2018, 32, 2323–2339.
16. Damle, M. Glycyrrhiza glabra (Liquorice)-A potent medicinal herb. Int. J. Herb. Med. 2014, 2, 132–136
17. Hayashi, H.; Yokoshima, K.; Chiba, R.; Fujii, I.; Fattokhov, I.; Saidov, M. Field survey of Glycyrrhiza plants in Central Asia (5). Chemical characterization of G. bucharica Collected in Tajikistan. Chem. Pharm. Bull. 2019, 67, 534–539.
18. Song-Yi Yang, Yu-Ri Choi, Myung-Jin Lee, Min-Kyung Kang. Antimicrobial Effects against Oral Pathogens and Cytotoxicity of Glycyrrhiza uralensis Extract. Plants 2020, 9 (7) , 838-846.
19. Jiang, M.; Zhao, S.; Yang, S.; Lin, X.; He, X.; Wei, X.; Song, Q.; Li, R.; Fu, C.; Zhang, J.; et al. An “Essential Herbal Medicine”—Licorice: A Review of Phytochemicals and Its Effects in Combination Preparations. J. Ethnopharmacol. 2020, 249, 112439.
20. Pastorino, G.; Cornara, L.; Soares, S.; Rodrigues, F.; Oliveira, M.B.P.P. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytother. Res. 2018, 32, 2323–2339.
21. Wang, L.; Yang, R.; Yuan, B.; Liu, Y.; Liu, C. The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb. Acta Pharm. Sin. B 2015, 5, 310–315.
22. Shibata, S. A Drug over the Millennia: Pharmacognosy, chemistry, and pharmacology of Licorice. Yakugaku Zasshi 2000, 120, 849–862.
23. ohma, H.S.; Gulçin, I. Antioxidant and radical scavenging activity of aerial parts and roots of Turkish liquorice (Glycyrrhiza glabra L.). Int. J. Food Prop. 2010, 13, 657–671.
24. Tang, Z.-H.; Li, T.; Tong, Y.-G.; Chen, X.-J.; Chen, X.-P.; Wang, Y.-T.; Lu, J.-J. A Systematic review of the anticancer properties of compounds isolated from licorice (Gancao). Planta Med. 2015, 81, 1670–1687.
25. Hatano, T.; Aga, Y.; Shintani, Y.; Ito, H.; Okuda, T.; Yoshida, T. Minor flavonoids from licorice. Phytochemistry 2000, 55, 959–963.
26. He, J.; Chen, L.; Heber, D.; Shi, W.; Lu, Q.Y. Antibacterial compounds from Glycyrrhiza uralensis. J. Nat. Prod. 2006, 69, 121–124.
27. Villinski, J.R.; Bergeron, C.; Cannistra, J.C.; Gloer, J.B.; Coleman, C.M.; Ferreira, D.; Azelmat, J.; Grenier, D.; Gafner, S. Pyrano-isoflavans from Glycyrrhiza uralensis with antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis. J. Nat. Prod. 2014, 77, 521–526.
28. Afreen, F.; Zobayed, S.M.; Kozai, T. Melatonin in Glycyrrhiza uralensis: Response of plant roots to spectral quality of light and UV-B radiation. J. Pineal Res. 2006, 41, 108–115.
29. Tsuge, A.; Hisaka, S.; Hayashi, H.; Nose, M. Effect of hot water extract of a glycyrrhizin-deficient strain of Glycyrrhiza uralensis on contact hypersensitivity in mice. J. Nat. Med. 2020, 74, 415–420.
30. hou, Y.; Jiao, Y.; Sun, Y.; Gao, S. In vitro production and distribution of flavonoids in Glycyrrhiza uralensis Fisch. J. Food Sci. Technol. 2020, 57, 1553– 1564.
31. Fenwick, G.R.; Lutomski, J.; Nieman, C. Liquorice, Glycyrrhiza glabra L.- Composition, uses and analysis. Food Chem. 1990, 38, 119–143.
32. Esmaeili, H.; Karami, A.; Hadian, J.; Nejad Ebrahimi, S.; Otto, L.G. Genetic structure and variation in Iranian licorice (Glycyrrhiza glabra L.) populations based on morphological, phytochemical and simple sequence repeats markers. Ind. Crop. Prod. 2020, 145, 112140.
33. ui-yan, G.; Li-dong, G.; Jing-hua, Y. Measurement and comparison of glycyrrhizic acid contents in root of licorice (Glycyrrhiza uralensis Fisch.) from different cultivating areas. J. For. Res. 2002, 13, 141–143.
34. Hayashi, H.; Hattori, S.; Inoue, K.; Khodzhimatov, O.; Ashurmetov, O.; Ito, M.; Honda, G. Field Survey of Glycyrrhiza plants in Central Asia (3). Chemical characterization of G. glabra collected in Uzbekistan. Chem. Pharm. Bull. 2003, 51, 1338–1340.
35. Rizzato, G.; Scalabrin, E.; Radaelli, M.; Capodaglio, G.; Piccolo, O. A new exploration of licorice metabolome. Food Chem. 2017, 221, 959–968.
36. Bao, F.; Bai, H.Y.; Wu, Z.R.; Yang, Z.G. Phenolic compounds from cultivated Glycyrrhiza uralensis and their PD-1/PD-L1 inhibitory activities. Nat. Prod. Res. 2021, 35, 562–569.
37. El-Saber Batiha, G.; Magdy Beshbishy, A.; El-Mleeh, A.; Abdel-Daim, M.M.; Prasad Devkota, H. Traditional uses, bioactive chemical constituents, and pharmacological and toxicological activities of Glycyrrhiza glabra L. (Fabaceae). Biomolecules 2020, 10, 352.
38. Jiang, J.; Zhang, X.; True, A.D.; Zhou, L.; Xiong, Y.L. Inhibition of lipid oxidation and rancidity in precooked pork patties by radical-scavenging licorice (Glycyrrhiza glabra) Extract. J. Food Sci. 2013, 78, C1686–C1694.
39. Xie, J.; Zhang, Y.; Wang, W.; Hou, J. Identification and simultaneous determination of glycyrrhizin, formononetin, glycyrrhetinic acid, liquiritin, isoliquiritigenin, and licochalcone A in licorice by LC-MS/MS. Acta Chromatogr. 2014, 26, 507–516.
40. Hatano, T.; Yasuhara, T.; Okuda, T. Anti-human immunodeficiency virus phenolics from Licorice). Chem. Pharm. Bull. 1988, 36, 2286–2288.