QUERCETIN AS THERAPEUTIC SOURCE FOR OVARIAN, UTERINE, AND HEPATO-RENAL PROFILE OF SPRAGUE DAWLEY RATS WITH LETROZOLE-INDUCED POLYCYSTIC OVARIAN SYNDROME

Abstract

Females of reproductive age are affected by Polycystic ovary syndrome (PCOS) all over the world.Traditional methods of treatment like metformin don,t provide cure but just symptomatic relieve and with many side effects. Current study compared the results in terms of improving the hormonal, biochemical, enzymatic, and histopathological profile along with nephro- renal protective activity in PCOS induced rat models, after treatment with quercetin, (50 mg/kg) in Letrozole (1.0 mg/Kg b. w./day) induced PCOS female Sprague Dawley rats (150-200gm) by keeping metformin (50 mg/Kg b.w.) as positive control. Statistically analyzed results (p<0.0001) showed that LH, homeostatic model assessment insulin resistance (HOMA-IR), AST, bilirubin and uric acid decreased in PCOS rats after treatment with quercetin, (0.8±0.05ng/dL, 0.07±0.05, 55.6 ±4.0 IU/L, 0.2 ±3.3 mg/dL and 2.3±0.7 mg/dL) as compared to control (2.09 ± 0.08 ng/dL, 0.12 ± 0.01, 181.3 ± 32.0 IU/L, 0.2 ± 0.1 mg/dL, 4.7 ± 0.15 mg/dL) respectively. Restoration in progesterone and estrogen were found significant in experimental groups (13.4±2.3 pg/dL, 53.5± 1.5pg/m\L) as compared to control (9.05±1.2pg/dL, 48± 5.2pg/mL) respectively with restoration of normal ovarian stroma from typical pearl string cystic appearance and normal hepato-renal tissues in histology. So it is concluded that quercetin, can be helpful to cure or mange PCOS .