EXPLORING THE SYNERGISTIC ANTIBACTERIAL POTENTIAL OF GRAPE SEED AND CRANBERRY FRUIT EXTRACT COMBINATION AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS
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Keywords
Grape seed extract, Cranberry fruit extract, Methicillin resistant Staphylococcus aureus, Antibiotic resistance, Meropenem, Linezolid.
Abstract
Objective: The investigation is designed to assess the combination of grape seed and cranberry extracts against MRSA through a synergistic effect.
Methodology: This in vitro study used clinical MRSA isolates for analysis. Grape seed and cranberry extracts were prepared at different concentrations, and their antibacterial capabilities were assessed using agar dilution techniques. The resulting zones of inhibition were measured for analysis.
Results: The study revealed that both Cranberry Fruit Extract (CFE) and Grape Seed Extract (GSE) demonstrated significant antibacterial activity against Methicillin-Resistant Staphylococcus aureus (MRSA) at various concentrations, even at the lowest concentration of 20mg/ml it showed a considerable 80% sensitivity rate and minimal resistance. The combination of CFE and GSE at different concentrations demonstrated outstanding antibacterial efficacy against MRSA, reaching 100% sensitivity at the highest concentration, surpassing common antibiotics like Meropenem. This combination exhibits great potential for clinical use in the fight against MRSA infections.
Conclusion: As antibiotic resistance continues its relentless ascent, the exploration of natural alternatives like grape seed and cranberry extracts becomes increasingly critical. These extracts not only demonstrate individual promise in combating MRSA but also exhibit the enticing potential for a synergistic effect when deployed together. Amid the pressing global concern over antibiotic resistance, these natural alternatives emerge as promising weapons in our arsenal against bacterial infections.
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Safia Abidi
Assistant Professor, Department of Pharmacognosy, Faculty of Pharmacy And Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
Nihal Fatima
Medical Officer, Baqai Medical University, Karachi, Pakistan.
Tayyaba Mumtaz
Associate Professor, Department of Pharmacognosy, Jinnah College of Pharmacy, Sohail University, Karachi, Pakistan.
Sidra Farooq
Assistant Professor, Department of Community Medicine, Heavy Industries Taxila Education City Institute of Medical Sciences, Taxilla, Pakistan.
Hira Naeem
Associate Professor, Department of Pharmacology, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan
Marium Tariq
Quality Assurance, CBSCR (Centre For Bioequivalence Studies and Clinical Research), ICCBS (International Centre For Chemical And Biological Sciences), University of Karachi, Karachi.
Sumreen Mujahid
Senior Lecturer, Department of Pharmacology and Therapeutics, Baqai Medical College, Baqai University, Karachi, Pakistan.