FOURIER TRANSFORM-INFRARED (FT-IR) ANALYSIS AND PHYTOPHARMACOGNOSTIC SCREENING OF THE ARIEAL PARTS OF CROTON BONPLANDIANUS
Main Article Content
Keywords
C. bonplandianus bark and leaves, phytochemical, microscopic evaluation, physicochemical analysis, FTIR spectroscopy
Abstract
Croton bonplandianus belongs to family Euphorbiaceae and it is an important traditional plants. Phytopharmacological analysis indicates that the leaves of C. bonplandianus significantly exhibited wound healing properties because of the presences of antioxidant enzymes and rutin etc. Present investigation comprises on organoleptic, microscopic, physicochemical and phytochemical analysis of aerial parts of this plant. Fourier Transform Infrared (FTIR) Spectrophotometer was also performed using leaves extract for the evaluation of peak value with various functional groups. Preliminary phytochemical screening was performed for the identification of medicinally valuable constituents. Fluorescence analysis was carried out to observe the behavior of powdered material with different reagents under UV light. All these parameters are used as tool for proper identification, authentication and standardization of plant material. Mid rib considerably curved upper epidermal and U-shaped lower epidermal cells while unicellular trichomes were short and branched at the base were exposed in histological assessment of the plant. Vascular bundle packed and conjoined. Wavy parenchymatous cells abundantly present with parasitic stomatas. The identical features of bark of C. bonplandianus were physically observed that exhibited wavy outline, barrel shaped, thick walled, compactly packed. Powdered leaves were revealed the presences of starch grain, stomata, parenchymatous cell and epidermal cells patches along with trichomes. Phytochemical studies indicated the presences of alkaloids, phenol, carbohydrates, steroids, saponins, proteins, and amino acids. FTIR analysis was conducted by spectrophotometric technique for the detection of functional groups and peaks values. FTIR spectrum profile of C. bonplandianus was generated for further estimation. This research would assist in future to reduces the chance of contamination, adulteration, improper &/or incorrect identification and purification, although supports the isolation of medicinally active constituents of C. bonplandianus.
References
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9. Dharmadasa R., Samarasinghe K., Adhihetty P., Hettiarachchi P. Comparative Pharmacognostic Evaluation of Munronia Pinnata (Wall.) Theob.(Meliaceae) and Its Substitute Andrographis paniculata (Burm. f.) Wall. Ex Nees (Acanthaceae). 2020
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11. Khan S., Shinwari M.I., Haq A., Ali K.W., Rana T., Badshah M., et al. Fourier-transform infrared spectroscopy analysis and antifungal activity of methanolic extracts of Medicago parviflora, Solanum Nigrum, Melilotus alba and Melilotus indicus on soil-borne phytopathogenic fungi. Pakistan Journal of Botany.50(4):1591-8. 2018
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16. Fatima K., Mahmud S., Yasin H., Asif R., Qadeer K., Ahmad I. Authentication of various commercially available crude drugs using different quality control testing parameters. Pak J Pharm Sci.33(4). 2020
17. Khadhraoui B., Turk M., Fabiano-Tixier A., Petitcolas E., Robinet P., Imbert R., et al. Histo-cytochemistry and scanning electron microscopy for studying spatial and temporal extraction of metabolites induced by ultrasound. Towards chain detexturation mechanism. Ultrason Sonochem.42:482-92. 2018
18. Sarfraz M., Alam F., Din K.M., Malik S., Quddoos A. Pharmacognostic characterization of Dicleptera chinensis by scanning electron microscopy, light microscopy, and analytical techniques. Microsc Res Tech.87(2):279-90. 2024
19. Singh D., Aeri V., Ananthanarayana D. Development of internet technology TIPHAM (Tool for identity of Powdered Herbals through Analytical Microscopy) for microscopic identification of crude herbal drugs. Pharmacogn Mag.14(55):213. 2018
20. Joseph T., Simon T.K. ORGANOLEPTIC AND POWDER CHARACTERISTICS AS TOOL FOR ANDROGRAPHIS SPECIES IDENTIFICATION. 2019
21. Sharma P.K., Mansoori S. Quantitative and Qualitative Analysis of Zingiber officinale as A Crude Drug. Research Journal of Pharmacy and Technology.12(5):2157-9. 2019
22. Kokate C. Preliminary phytochemical screening. Practical pharmacognosy.106-11. 2000
23. Devi M.R., Krishnakumari S. Quantitative estimation of primary and secondary metabolites in hot aqueous extract of Pleurotus sajor caju. Journal of Pharmacognosy and Phytochemistry.4(3):198. 2015
24. Kaur G., Rubal K., Srivastava D.K., Singh P.K., Ahluwalia A.S. Morpho-histological study in the gynodioecious Salvia strobilifera (Lamiaceae). Vegetos.1-12. 2024
25. Khan A., Ahmad M., Sultan A., Khan R., Raza J., Ul Abidin S.Z., et al. Herbal Spices as Food and Medicine: Microscopic Authentication of Commercial Herbal Spices. Plants.13(8):1067. 2024
26. Ranjith D. Fluorescence analysis and extractive values of herbal formulations used for wound healing activity in animals. J Med Plant Studies.6(2):189-92. 2018
27. Ramya S., Loganathan T., Chandran M., Priyanka R., Kavipriya K., Pushpalatha G.G.L., et al. Phytochemical Screening, GCMS, FTIR profile of Bioactive Natural Products in the methanolic extracts of Cuminum cyminum seeds and oil. Journal of Drug Delivery and Therapeutics.12(2-S):110-8. 2022
28. Yasin H., Khalid S., Abrar H., Rizwani G.H., Perveen R., Fatima K. Comperative phyto toxicological and anti inflammatory effects of leaves extracts of holoptelea integrifolia. Bangladesh Journal of Medical Science.17(2):212-7. 2018
29. Newbould B. Chemotherapy of arthritis induced in rats by mycobacterial adjuvant. British journal of pharmacology and chemotherapy.21(1):127-36. 1963
30. Mansouri M.T., Hemmati A.A., Naghizadeh B., Mard S.A., Rezaie A., Ghorbanzadeh B. A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats. Indian Journal of Pharmacology.47(3):292. 2015
31. Noorian P. Evaluation of Gallic Acid anti-inflammatory effect on PGE2 and COX-2 in carrageenan induced rat paw edema: Mazandaran University of Medical Sciences; 2020.
32. Yasin H., Mahmud S., Rizwani G.H., Perveen R., Abrar H., Fatima K. Effects of aqueous leaves extract of Holoptelea integrifolia (Roxb) Planch on liver and kidney histopathology of albino rats. Pak J Pharm Sci.32(2). 2019
33. Khalid S., Rizwan G., Yasin H., Perveen R., Abrar H. Medicinal Importance of Holoptelea Integrifolia (Roxb). Planch–Its Biological and Pharmacological Activities. Nat Prod Chem Res 2: 124 doi: 10.4172/2329-6836.1000124 Page 2 of 4 seasonal variation of airborne pollen has been reported. Bulk of pollens originates from anemophilous trees and grasses. Thirteen pollen types have been recorded on more than 1% of annual total pollen catch. Holoptelea integrifolia. 2013
34. Nematbakhsh M., Ashrafi F., Safari T., Talebi A., Nasri H., Mortazavi M., et al. Administration of vitamin E and losartan as prophylaxes in cisplatin-induced nephrotoxicity model in rats. Journal of nephrology.25(3):410. 2012
35. Eshraghi-Jazi F., Nematbakhsh M., Nasri H., Talebi A., Haghighi M., Pezeshki Z., et al. The protective role of endogenous nitric oxide donor (L-arginine) in cisplatin-induced nephrotoxicity: Gender related differences in rat model. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences.16(11):1389. 2011
36. Ramhit P., Ragoo L., Bahorun T., Neergheen-Bhujun V. Multi-targeted effects of untapped resources from the Mauritian endemic flora. South African Journal of Botany.115:208-16. 2018
37. Morilla L.J.G., Demayo C.G. Medicinal Plants Used by Traditional Practitioners in Two Selected Villages of Ramon Magsaysay, Zamboanga Del Sur. Pharmacophore.10(1):84-92. 2019
38. Ayyanar M., Ignacimuthu S. Ethnobotanical survey of medicinal plants commonly used by Kani tribals in Tirunelveli hills of Western Ghats, India. J Ethnopharmacol.134(3):851-64. 2011
39. Shaheen S., Ramzan S., Khan F., Ahmad M. Adulteration A Global Issue. Adulteration in Herbal Drugs: A Burning Issue: Springer; 2019. p. 1-8.
40. Kumar D.P., Umasankar K., Alagusundaram M., Jayachandra Reddy P. Current Trends in Regulatory Authority Actions against Misbranded and Adulterated Drugs. International Journal of Advance Research, Ideas and Innovation in Technology.3(3):1513-21. 2017
41. Laloo D., Sahu A., Hemalatha S., Dubey S. Pharmacognostical and phytochemical evaluation of Cinnamomum wightii Meissn. flowers. 2012
42. Ghosh A., Laloo D., Singh N.K. Comparative estimation and chemical standardization of new and old sample of Chyawanprash. Int J Pharm Pharm Sci.5(3):801-4. 2013
43. Gautam A., Kashyap S.J., Sharma P.K., Garg V.K., Visht S., Kumar N. Identification, evaluation and standardization of herbal drugs: A review. Der Pharmacia Lettre.2(6):302-15. 2010
44. Kumar N., Chaudhary A. Pharmacognostic and phytochemical evaluation of Prunus persica (L.). International Journal of Research and Development in Pharmacy & Life Sciences.6(6):2806-12. 2017
45. Bhavana R., Thomas R.R., Binu. COMPARATIVE STUDIES ON MORPHOLOGY, ANATOMY AND PHYTOCHEMISTRY OF SELECTED SPECIES OF CROTON L.(EUPHORBIACEAE). Plant Archives.20(1):639-56. 2020
46. Dutta S., Chakraborty A.K., Dey P., Kar P., Guha P., Sen S., et al. Amelioration of CCl4 induced liver injury in swiss albino mice by antioxidant rich leaf extract of Croton bonplandianus Baill. PloS one.13(4). 2018
47. Somit D., Priyankar D., Kumar C.T. Quantification and correlation of the bioactive phytochemicals of Croton bonplandianum leaves of Sub-Himalayan region of West Bengal. Asian J Pharm Clin Res.6(3):142-7. 2013
48. Pande C., Tewari J. Chemical examination of Croton sparsiflorous. Journal Indian Chemical Society.39:545-52.1962
49. Qureshi S., Reddy A.V., Kumar G., Nousheen L. Pharmacognostic, physicochemical standardization and phytochemicalanalysis of leaves of Hydrolea zeylanica Vahl.(Hydrophyllaceae). Research Journal of Pharmacognosy and Phytochemistry.9(1):1-7. 2017
50. Dassanayaka G.G., Sivasinthujah S., Christy Jeyaseelan T. Physicochemical and preliminary phytochemical analysis of different brands ofHingwashtak churna; a polyherbal medicine in Sri Lanka. 2024
51. Organization W.H. Quality control methods for medicinal plant materials: World Health Organization; 1998.
52. Unit P., Organization W.H. Quality control methods for medicinal plant materials. World Health Organization, 1992.
53. Mohan V.R., Kalidass C. Nutritional and antinutritional evaluation of some unconventional wild edible plants. Tropical and subtropical Agroecosystems.12(3):495-506. 2010
54. Yumnamcha T., Nongthomba U., Devi M.D. Phytochemical screening and evaluation of genotoxicity and acute toxicity of aqueous extract of Croton tiglium L. International Journal of Scientific and Research Publications.4(1):1-5. 2014
55. Pucker B., Reiher F., Schilbert H.M. Automatic identification of players in the flavonoid biosynthesis with application on the biomedicinal plant Croton tiglium. Plants.9(9):1103. 2020
56. Shirmohammadli Y., Efhamisisi D., Pizzi A. Tannins as a sustainable raw material for green chemistry: A review. Industrial Crops and Products.126:316-32. 2018
57. Hassanpour S., MaheriSis N., Eshratkhah B. Plants and secondary metabolites (Tannins): A Review. 2011
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Published
Jun 26, 2024
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How to Cite
Hina Yasin, Shaukat Khalid, Hina Abrar, Kaneez Fatima, Kiran Qadeer, & Hira Naeem. (2024). FOURIER TRANSFORM-INFRARED (FT-IR) ANALYSIS AND PHYTOPHARMACOGNOSTIC SCREENING OF THE ARIEAL PARTS OF CROTON BONPLANDIANUS. Journal of Population Therapeutics and Clinical Pharmacology, 31(6), 1810–1825. https://doi.org/10.53555/jptcp.v31i6.6769
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Author Biographies
Hina Yasin
Dow College of Pharmacy, Dow University of Health Sciences, Ojha Campus, Gulzar E Hijri, Scheme-33, Karachi, Pakistan
Shaukat Khalid
Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Super Highway, Gadap Road, Karachi, Pakistan
Hina Abrar
Dow College of Pharmacy, Dow University of Health Sciences, Ojha Campus, Gulzar E Hijri, Scheme-33, Karachi, Pakistan
Kaneez Fatima
Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Rafiqui H.J Shaheed Road, Karachi, Pakistan
Kiran Qadeer
Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Rafiqui H.J Shaheed Road, Karachi, Pakistan
Hira Naeem
Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Super Highway, Gadap Road, Karachi, Pakistan