APPLICATION OF ETHANOL-INJECTION TECHNIQUE FOR FORMULATION OF VITEXIN LOADED NOISOMES AND CHARACTERIZATION OF THE VESICLES
Main Article Content
Keywords
Vitexin, inflammation noisome, ethanol-injection, entrapment
Abstract
In the present study niosomes of vitexin were developed by ethanol injection method and were characterized for particle size, entrapment and drug release and release kinetics. The niosomes prepared using either span 60, tween 80 or tween 20 as the non-ionic surfactants and cholesterol as the lipid were evaluated for particle size, entrapment efficiency and in vitro release. Increasing the HLB value of the surfactant was found to increase the particle size of the vesicles. On the other hand, surfactant with lower HLB also exhibited better entrapment efficiency. The entrapment efficiency of the formulations was found to be in the range of 55 – 71%. The release of vitexin from the prepared niosomes ranged from 60.78 % to 76.37%. Formulation F3 presented the lowest particles size (229.6 nm), higher entrapment efficiency (71%) and sustained release of vitexin over 24 hours (65.53) and was considered the best formulation. The release of vitexin from the F3 depicted Higuchi and Korsemeyer-Peppas type of mechanism at these two models presented higher linearity compared to the first-order and zero-order models
References
2. Gurjar P, Naik N, Chouksey S. Niosome: A Promising Pharmaceutical Drug Delivery. Int J Pharmaceut Drug Anal 2014; 2(5): 425-431.
3. https://pubchem.ncbi.nlm.nih.gov/compound/Vitexin, assessed on 03/01/2023
4. Costa EC, Menezes PMN, Lúcio de Almeida R, Silva FS, Augusto de Araújo Ribeiro L, Almada de Silva J, Paula de Oliveira A, Cavalcante da Cruz Araújo E, Rolim LA, Nunes XP. Inclusion of vitexin in β-cyclodextrin: preparation, characterization and expectorant/antitussive activities. Heliyon. 2020; 6: e05461. doi: 10.1016/j.heliyon.2020.e05461
5. Peng Y, Gan R, Li H, Yang M, McClements DC, Gao R, Sun Q. Absorption, metabolism, and bioactivity of vitexin: recent advances in understanding the efficacy of an important nutraceutical. Critical Reviews In Food Science And Nutrition. 2020; 1-16. doi: 10.1080/10408398.2020.1753165
6. Chen W, Zhou S, Ge L, Wu W, Jiang X. Translatable High Drug Loading Drug Delivery Systems Based on Biocompatible Polymer Nanocarriers. Biomacromolecules. 2018; 19(6): 1732-1745
7. Shivapriya G, Bhagavathy S. Formulation, Characterization and In vitro Drug Delivery of Vitexin Loaded Liposomes. International Journal of Pharmaceutical Sciences and Nanotechnology. 2021; 14(2): 5364-5371
8. Chomchoey S, Klongdee S, Peanparkdee M, Klinkesorn U. Fabrication and characterization of nanoemulsions for encapsulation and delivery of vitexin: antioxidant activity, storage stability and in vitro digestibility. Journal of the Science of Food and Agriculture. 2022; doi: 10.1002/jsfa.12375
9. Estupiñan OR, Garcia-Manrique P, Blanco-Lopez MdC, Matos M, Gutiérrez G. Vitamin D3 Loaded Niosomes and Transfersomes Produced by Ethanol Injection Method: Identification of the Critical Preparation Step for Size Control. Food. 2020; 9: 1367. doi:10.3390/foods9101367
10. Imam SS, Aqil M, Akhtar M, Sultana Y, Ali A. Formulation by design-based proniosome for accentuated transdermal delivery of risperidone: in vitro characterization and in vivo pharmacokinetic study. Drug Delivery. 2015; 22(8): 1059–1070.
11. Pando D, Matos M, Gutiérrez G, Pazos C. Formulation of resveratrol entrapped niosomes for topical use. Colloids and Surfaces B. 2015; 128: 398–404.
12. García-Manrique P, Gutiérrez PG, Matos M, Cristaldi A, Mosayyebi A, Carugo D, Zhang X, Blanco-Lopez MC. Continuous flow production of size-controllable niosomes using a thermostatic microreactor. Colloids and Surfaces B. 2019; 182: a110378.
13. Barani M, Mirzaei M, Torkzadeh-Mahani M, Lohrasbi-Nejad A, Nematollahi MH. A new formulation of hydrophobin-coated niosome as a drug carrier to cancer cells. Material Science Engineering. 2020; 113: a110975.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Pushpendra Kumar
Radharaman Institute of Pharmaceutical Sciences, Bhopal
Kapil Malviya
Radharaman Institute of Pharmaceutical Sciences, Bhopal
Pushpendra Soni
Radharaman Institute of Pharmaceutical Sciences, Bhopal
Lavakesh Kumar Omray
Radharaman Institute of Pharmaceutical Sciences, Bhopal