SERUM ALBUMIN AS AN INDEPENDENT INDICATOR IN GUILLAIN–BARRE SYNDROME PATIENTS UNDERGOING PLASMAPHERESIS
Main Article Content
Keywords
Guillain–Barré syndrome, serum albumin, plasmapheresis, prognostic marker, Hughes Functional Grading Scale, neurological outcomes
Abstract
Introduction: Guillain-Barré syndrome (GBS) is an immune-mediated neuropathy of acute onset. Early intervention and management was determined by the identification of readily available biomarkers to forecast the outcome in patients undergoing plasmapheresis.
Objective: To investigate the value of serum albumin as a sole prognostic indicator for GBS patients undergoing plasmapheresis, and its association with disease severity, treatment response, and short-term outcomes.
Materials and Methods: This was a prospective observational study conducted at Department of General Medicine, Northwest General Hospital and Research Centre, Peshawar, Pakistan in the duration from September, 2024 to February, 2025. Sixty GBS patients who met the inclusion criteria underwent measurement of serum albumin both before and after treatment, neurological evaluation, and outcome evaluation.
Results: Lower baseline albumin was found to have a significant relation to a higher Hughes Functional Grading Scale score, higher ICU admissions, need for mechanical ventilation, and poorer recovery. A reduction in serum albumin levels was found to be measurable with plasmapheresis.
Conclusion: Serum albumin is an easy, inexpensive, and meaningful prognostic biomarker in GBS patients undergoing plasmapheresis, which helps risk stratification and individual care of the patient.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Jehan Anjum
MBBS, FCPS General Medicine, Consultant Physician, Medical Specialist at Employees Social Security Institution Polyclinic Kohat Road Peshawar, Pakistan
Muhammad Atiq Ur Rehman
Assistant Professor of Medicine, Aman Anayat Medical College Sheikhupura, Pakistan
Hamza Nazir
Post Graduate Resident, Department of General Medicine, Northwest General Hospital and Research Centre, Peshawar, Pakistan
Mahwash Mengal
Assistant Professor, Department of Physiology, Bolan Medical College Quetta, Balochistan, Pakistan
Tanni Jahan Dina
MBBS, Sheikh Hasina Medical College and Hospital, Tangail, Bangladesh
Dial Das
Associate Professor, Department of Pharmacology, Chandka Medical College, Larkana,
Sindh, Pakistan