EFFECTS OF HIGH DOSE VITAMIN C IN CRITICALLY ILL COVID-19 PATIENTS
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Keywords
High dose vitamin C, COVID-19, seriously sick, mortality, ICU length of stay, inflammation, PaO2/FiO2 ratio
Abstract
Introduction: COVID-19 has caused high critical illness, severe cases in most cases leading to high mortality and extended ICU stays. High dose Vitamin C (HDIVC) has been put forward as an adjunctive alternative, given its anti-oxidant and anti-inflammatory functions.
Objective: To assess the efficacy of high dose vitamin C for mortality reduction, improved clinical outcomes, and regulation of inflammation in severely affected COVID-19 patients.
Materials and Method: A randomly controlled trial was also performed at multi centers including Chandka Medical College, Larkana Sindh, Pakistan and Azra Naheed Medical College, Lahore, Pakistan in the duration from January, 2024 and June, 2024. Sixty patients were treated with HDIVC (200 mg/kg/d), and 60 patients underwent standard therapy. Mortality and ICU length of stay were primary endpoints, and oxygenation and inflammatory markers were secondary.
Results: The HDIVC group showed reduced mortality (16.7% vs. 30%), shorter ICU stays (8.5 vs. 10.3 days), improved PaO2/FiO2 ratios, and lower inflammatory markers.
Conclusion: HDIVC may significantly enhance clinical results in critically sick COVID-19 patients.
References
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Hafiza Amna Benazir
Senior House Officer, Department of General Internal Medicine, Ennis General Hospital Ireland
Bilal Masood
Assistant Professor, Department of Community Medicine, Bolan Medical College Quetta, Pakistan
Sara Bano
Senior Registrar Medical Unit 1, Department of Medicine, Arif Memorial Teaching Hospital, Pakistan. Email: sara.bano210@gmail.com
FNU Soxi
MD, Department of Internal Medicine, Jersey City Medical Center
Dial Das
Associate Professor, Department of Pharmacology, Chandka Medical College, Larkana
Sindh, Pakistan.
Rashid Ali Khosa
Assistant Professor Pharmacology, Mekran Medical College, Turbat, Pakistan