FREQUENCY OF ANTI HCV ANTIBODIES IN TYPE II DIABETES MELLITUS PATIENTS ATTENDING TERTIARY CARE HOSPITAL
Main Article Content
Keywords
Co-Infection, Blood Transfusions, psychological, Hepatitis C virus (HCV), Prevalence
Abstract
Background: Hepatitis C virus (HCV) co-infection in patients with type 2 diabetes mellitus (T2DM) is a growing concern, especially in regions with limited access to healthcare. Both conditions are associated with significant morbidity and can complicate disease management. Understanding the prevalence, risk factors, and impact of HCV co-infection in T2DM patients is crucial for effective management and treatment.
Objective: This study aimed to assess the prevalence of HCV co-infection in patients with T2DM, identify associated risk factors, and explore the psychological impact of the co-infection. Method: A cross-sectional study was conducted at a tertiary care hospital in Quetta, Pakistan. A total of 200 T2DM patients were screened for HCV. Data was collected through structured interviews, patient records, and laboratory testing. Risk factors were analyzed, and psychological distress was measured using standardized scales.
Results: The prevalence of HCV co-infection among T2DM patients was found to be 28%. Key risk factors included a history of blood transfusions, uncontrolled diabetes, and rural residency. Psychological distress, including symptoms of anxiety and depression, was reported by 40% of participants. Financial constraints and low awareness of the co-infection were significant barriers to diagnosis and treatment.
Conclusion: HCV co-infection is highly prevalent among T2DM patients, with significant risk factors identified. The study highlights the need for targeted interventions addressing medical, psychological, and educational aspects to improve patient outcomes and quality of life. Comprehensive screening and awareness programs are essential to manage and mitigate the impact of this co-infection.
References
2. Gane EJ. The natural history of recurrent hepatitis C and what influences this. Liver Transplant. 2008;14(2):36–44.
3. Foster GR, Goldin RD, Thomas HC. Chronic hepatitis C virus infection causes a significant reduction in quality of life in the absence of cirrhosis. Hepatology. 1998; 27:209–12.
4. Shinn JH, Liang KC. Chronic hepatitis C and Diabetes Mellitus. Chinese J Med Assoc. 2006;69(4):143–5.
5. Alter MJ. Epidemiology of Hepatitis C virus. J Hepatol. 1997;26:625–55.
7. Elfiky AA, Elshemey WM, Gawad W, Desoky O. Molecular modeling comparison of the performance of NS5b polymerase inhibitor (PSI-7977) on prevalent HCV genotypes. Protein J. 2013;32(1):75–80.
8. Mehta SH, Brancati FL, Strathdee SA, Pankow JS, Netski D, Coresh J, Szklo M, Thomas DL. Hepatitis C virus infection and incident type 2 diabetes. Hepatology. 2003;38(1):50–6. https://doi.org/10.1053/jhep.50291.
9. Imam K. Clinical features, diagnostic criteria and pathogenesis of diabetes mellitus. Adv Exp Med Biol. 2012; 771:340–55.
10. Peck T, Price C, English P, Gill G. Oral health in rural South African type 2 diabetic patients. Trop Dr. 2006;36(2):111–2.
11. Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet. 2014;383: 69–82.
12. Knobler H, Schihmanter R, Zifroni A, Fenakel G, Schattner A. Increased risk of type 2 diabetes in noncirrhotic patients with chronic hepatitis C virus infection. Mayo Clin Proc. 2000;75:355–9.
13. Zein CO, Levy C, Basu A, Zein NN. Chronic hepatitis C and type II diabetes mellitus: a prospective cross-sectional study. Am J Gastroenterol. 2005; 100(1):48–55.
14. Younossi ZM, Stepanova M, Nader F, Younossi Z, Elsheikh E. Associations of chronic hepatitis C with metabolic and cardiac outcomes. Aliment Pharmacol Ther. 2013;37(6):647–52.
15. Naing C, Mak JW, Ahmed SI, M. Maung M. Relationship between hepatitis C virus infection and type 2 diabetes mellitus: meta-analysis. World J Gastroenterol. 2012;18(14):1642–51
16. Antonelli, A., Ferri, C., Pampana, A., et al. (2009). Hepatitis C virus infection: Evidence for an association with type 2 diabetes. Diabetes Care, 32(7), 1126–1130.
17. Ali, S., Ali, M. N., Afzal, M., et al. (2017). Prevalence and risk factors of HCV in diabetes mellitus patients. Journal of Infectious Diseases, 14(2), 45–50.
18. Negro, F., & Alaei, M. (2009). Hepatitis C virus and type 2 diabetes. World Journal of Gastroenterology, 15(13), 1537–1547.
19. Bugianesi, E., Salamone, F., & Negro, F. (2001). The interaction of metabolic factors with HCV infection. Diabetes/Metabolism Research and Reviews, 17(5), 327–333.
20. Lonardo, A., et al. (2004). Hepatic steatosis and insulin resistance in HCV infection. Journal of Hepatology, 41(6), 790–795.
21. Zein, C. O., et al. (2005). Diabetes and liver fibrosis in HCV patients. Hepatology, 41(3), 566–574.
22. Romero-Gómez, M., Fernández-Rodríguez, C. M., & Andrade, R. J. (2015). DAAs improve glucose metabolism in HCV patients. Clinical Gastroenterology and Hepatology, 13(1), 10–17.
23. White, D. L., Ratziu, V., & El-Serag, H. B. (2008). Hepatitis C infection and risk of diabetes: A systematic review and meta-analysis. Journal of Hepatology, 49(5), 831–844.
24. Poustchi, H., Ghajar, A., & Malekzadeh, R. (2011). Impact of diabetes on the outcome of HCV treatment. Hepatology International, 5(3), 681–688.
25. Younossi, Z. M., et al. (2013). Regional variations in HCV-T2DM prevalence. Liver International, 33(9), 1278–1284.