NUTRITIONAL AND MEDICINAL PROPERTIES OF SEA BUCKTHORN AND COMPREHENSIVE REVIEW OF ITS PHYTOCHEMICAL CONSTITUENTS AND HEALTH BENEFITS
Main Article Content
Keywords
Sea buckthorn, Phytochemicals, Omega, Hepatoprotective, Antioxidant
Abstract
This review evaluates the medicinal and therapeutic potential of sea buckthorn, a thorny shrub, belongs to a family Elaeagnaceae in the prevention and management of multiple maladies, both acute and chronic. Owing to its nutritional and therapeutic qualities, the plant is utilized throughout the world, but most frequently in Europe and Asia. Preparations derived from sea buckthorn have been widely used in ancient cultures to treat ailments as ulcers, lagging digestion, gastroenteritis, cardiovascular issues, liver disease, tendon and ligament injuries, and skin disorders. Pharmacological and therapeutic properties of Sea buckthorn have been thoroughly studied in recent years utilizing several kinds of in vitro and in vivo models in addition to a small number of clinical trials. Numerous traditional uses of sea buckthorns have been validated by scientific analysis, pharmacological and phytochemical content investigation. It is well known that sea buckthorn exhibits immunomodulatory, anti- inflammatory, and antioxidant properties. Particularly, berries include vitamin C, which supports the immune system, both the seeds and pulp oil provide omegas 3, 6, 7 and 9 are beneficial to the skin, the cardiovascular system, and the metabolism. Given its vast therapeutic and pharmacological potential, sea buckthorn is undoubtedly an essential plant. However, this study's identification of a number of information gaps will spur further research and development, particularly in the area of sea buckthorn-based nutraceuticals and herbal medicine.
References
1. Aguiló-Aguayo, I. & Plaza, L. 2017. Innovative Technologies in Beverage Processing, John Wiley & Sons.
2. Ahani, H., & Attaran, S. (2022). Therapeutic potential of Seabuckthorn (Hippophae rhamnoides L.) in medical sciences. Cellular, Molecular and Biomedical Reports, 2(1), 22-32.
3. Akhter, P., Bhatti, T. Y., Shafiq, I., Jamil, F., Nazar, R., Nazir, M. S., . . . Park, Y. (2023). Antioxidant activity of sea buckthorn (Hippophae rhamnoides) seed oil extracted using various organic solvents.
4. Korean Journal of Chemical Engineering, 40(12), 2914-2920.
5. Anchidin, B.-G., Manoliu, D.-R., Ciobotaru, M.-C., Ciobanu, M. M., Gucianu, I., Sandu, G.-A., & Boișteanu, P. C. (2023). DEVELOPMENT OF A FUNCTIONAL MEAT PRODUCT WITH SEA BUCKTHORN OIL AND ANALYSIS OF ITS SENSORY AND PHYSICOCHEMICAL QUALITY. Scientific
6. Papers. Series D. Animal Science, 66(1).
7. Antache, A., Petrea, S.-M., Simionov, I.-A., Nica, A., Cristea, V., Georgescu, P. L., . . . Ciobîcă, A. (2023). EFFECT OF DIETARY SUPPLEMENTATION OF Nile tilapia WITH SEA BUCKTHORN AND VITAMIN E ON THE HEMATOLOGICAL AND SERUM BIOCHEMICAL INDICES. Scientific Papers.
8. Series D. Animal Science, 66(2).
9. Ao, X., Mu, Y., Xie, S., Meng, D., Zheng, Y., Meng, X., & Lv, Z. (2022). Impact of UHT processing on volatile components and chemical composition of sea buckthorn (Hippophae rhamnoides) pulp: A prediction of the biochemical pathway underlying aroma compound formation. Food Chemistry, 390, 133142.
10. Arif, S., Ahmed, H. M., Attacha, S., Attia, K. A., Mohammed, A. A., Ishaq, S., . . . Yang, S. H. (2024). Molecular Characterization and Comparative Transcriptomic Analysis of Hr-Lcyb and Hr-Psy Genes for Carotenoids Synthesis in Sea Buckthorn (Hippophae rhamnoides L.). Journal of Soil Science and Plant Nutrition, 1-12.
11. Attri, S., & Goel, G. (2020). Sea Buckthorn Berries: A Richer Source of Nutrition and Potential Health Benefits Asian Berries (pp. 221-237): CRC Press.
12. Balta, I., Stef, L., Pet, I., Iancu, T., Stef, D. & Corcionivoschi, N. 2021. Essential fatty acids as biomedicines in cardiac health. Biomedicines, 9, 1466.
13. Barkhuu, B., Lodonjav, M., Ganzorig, O., & Tumurtogoo, N. (2021). The Physicochemical Composition of Sea Buckthorn (Hippophae rhamnoides L) Oil and Its Treatment Characteristics. Paper presented at the 5th International Conference on Chemical Investigation and Utilization of Natural Resource (ICCIUNR-2021).
14. Bartish, I. V., & Thakur, R. (2022). Genetic diversity, evolution, and biogeography of seabuckthorn The Seabuckthorn Genome (pp. 23-66): Springer.
15. Bass, V. L., Soukup, J. M., Ghio, A. J., & Madden, M. C. (2020). Oleic acid and derivatives affect human endothelial cell mitochondrial function and vasoactive mediator production. Lipids in Health and Disease, 19, 1-9.
16. Bruno, G. M., Dovera, F., Ciccarone, A., & Colombo, G. L. (2022). Overview of Nutraceuticals and Cardiometabolic Diseases following Socio-Economic Analysis. Endocrines, 3(2), 255-295.
17. Cavak, N., Gümüştaş, M. & Demirci Cekic, S. 2022. The Protective Role of Hippophae rhamnoides L. on Rat Brain and Liver Tissues Exposed to Cold Plus Immobilization Stress Model. Turkish Neurosurgery, 32.
18. CHAO, C.-T., YEH, H.-Y., TSAI, Y.-T., CHUANG, P.-H., YUAN, T.-H., HUANG, J.-W. & CHEN, H.-W. 2019. Natural and non-natural antioxidative compounds: potential candidates for treatment of vascular calcification. Cell Death Discovery, 5, 145.
19. Chen, A., Feng, X., Dorjsuren, B., Chimedtseren, C., Damda, T.-A., & Zhang, C. (2023). Traditional food, modern food and nutritional value of Sea buckthorn (Hippophae rhamnoides L.): A review.
20. Journal of Future Foods, 3(3), 191-205.
21. Chen, K., Zhou, F., Zhang, J., Li, P., Zhang, Y., & Yang, B. (2022). Dietary supplementation with sea buckthorn berry puree alters plasma metabolomic profile and gut microbiota composition in hypercholesterolemia population. Foods, 11(16), 2481.
22. Ciesarová, Z., Murkovic, M., Cejpek, K., Kreps, F., Tobolková, B., Koplík, R., . . . Panovská, Z. (2020). Why is sea buckthorn (Hippophae rhamnoides L.) so exceptional? A review. Food Research International, 133, 109170.
23. Criste, A., Urcan, A. C., Bunea, A., Pripon Furtuna, F. R., Olah, N. K., Madden, R. H. & Corcionivoschi, N. 2020. Phytochemical composition and biological activity of berries and leaves from four Romanian sea buckthorn (Hippophae rhamnoides L.) varieties. Molecules, 25, 1170.
24. Čulina, P., Balbino, S., Jokić, S., Dragović-Uzelac, V., & Pedisić, S. (2024). Efficiency of Supercritical CO2 and Ultrasound-Assisted Extraction Techniques for Isolation of Bioactive Molecules from Sea Buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) Berry Oils and Cakes. Processes, 12(4), 698.
25. Dienaitė, L., Pukalskas, A., Pukalskienė, M., Pereira, C. V., Matias, A. A. & Venskutonis, P. R. 2020. Phytochemical composition, antioxidant and antiproliferative activities of defatted sea buckthorn (Hippophaë rhamnoides L.) berry pomace fractions consecutively recovered by pressurized ethanol and water. Antioxidants, 9, 274.
26. Ding, J., Ruan, C., Guan, Y., Li, H., Du, W., Lu, S., . . . Chen, Y. (2022). Nontargeted metabolomic and multigene expression analyses reveal the mechanism of oil biosynthesis in sea buckthorn berry pulp rich in palmitoleic acid. Food Chemistry, 374, 131719.
27. Dong, K., Binosha Fernando, W. M., Durham, R., Stockmann, R., & Jayasena, V. (2023). Nutritional value, health-promoting benefits and food application of sea buckthorn. Food Reviews International, 39(4), 2122-2137.
28. Du, L., Liu, Y., Wan, L., Chen, C., & Fan, G. (2020). Seabuckthorn Berries Attenuate Pulmonary Vascular Hyperpermeability in Lipopolysaccharide-induced Acute Lung Injury in Mice.
29. Du, W., Ding, J., Lu, S., Wen, X., Hu, J., & Ruan, C. (2022). Identification of the key flavonoid and lipid synthesis proteins in the pulp of two sea buckthorn cultivars at different developmental stages. BMC Plant Biology, 22(1), 299.
30. Dudau, M., Codrici, E., Tarcomnicu, I., Mihai, S., Popescu, I. D., Albulescu, L., . . . Rambu, D. (2021). A fatty acid fraction purified from sea buckthorn seed oil has regenerative properties on normal skin cells. Frontiers in Pharmacology, 12, 737571.
31. Dupak, R., Hrnkova, J., Simonova, N., Kovac, J., Ivanisova, E., Kalafova, A., Schneidgenova, M., Prnova, M. S., Brindza, J. & Tokarova, K. 2022. The consumption of sea buckthorn (Hippophae rhamnoides L.) effectively alleviates type 2 diabetes symptoms in spontaneous diabetic rats. Research in veterinary science, 152, 261-269.
32. El-Sohaimy, S. A., Shehata, M. G., Mathur, A., Darwish, A. G., Abd El-Aziz, N. M., Gauba, P., & Upadhyay, P. (2022). Nutritional evaluation of sea buckthorn “Hippophae rhamnoides” berries and the pharmaceutical potential of the fermented juice. Fermentation, 8(8), 391.
33. Farag, M. A., & Gad, M. Z. (2022). Omega-9 fatty acids: Potential roles in inflammation and cancer management. Journal of Genetic Engineering and Biotechnology, 20(1), 48.
34. Galitsyn, G., Lomovskiy, I., & Podgorbunskikh, E. (2023). Seasonal and Geographic Variation in Serotonin Content in Sea Buckthorn. Plant Foods for Human Nutrition, 78(1), 186-192.
35. Gâtlan, A.-M., & Gutt, G. (2021). Sea buckthorn in plant based diets. An analytical approach of sea buckthorn fruits composition: Nutritional value, applications, and health benefits. International journal of environmental research and public health, 18(17), 8986.
36. Gâtlan, A.-M. & Gutt, G. 2021. Sea buckthorn in plant based diets. An analytical approach of sea buckthorn fruits composition: Nutritional value, applications, and health benefits. International journal of environmental research and public health, 18, 8986
37. Green, R. C. 2007. Physicochemical properties and phenolic composition of selected Saskatchewan fruits: buffaloberry, chokecherry and sea buckthorn. University of Saskatchewan.
38. Guo, R., Chang, X., Guo, X., Brennan, C. S., Li, T., Fu, X. & Liu, R. H. 2017. Phenolic compounds, antioxidant activity, antiproliferative activity and bioaccessibility of Sea buckthorn (Hippophaë rhamnoides L.) berries as affected by in vitro digestion. Food & function, 8, 4229-4240.
39. Hao, W., He, Z., Zhu, H., Liu, J., Kwek, E., Zhao, Y., . . . Chen, Z.-Y. (2019). Sea buckthorn seed oil reduces blood cholesterol and modulates gut microbiota. Food & Function, 10(9), 5669-5681.
40. Ibrahim, I., Shalaby, A., Abdallah, H., El-Zohairy, N. & Bahr, H. 2020. Immunomodulatory and anti-angiogenic properties of Linum usitatissium (flaxseed) seeds ethanolic extract in atherogenic diet treated rats. Adv. Anim. Vet. Sci, 8, 18-25.
41. Janceva, S., Andersone, A., Lauberte, L., Bikovens, O., Nikolajeva, V., Jashina, L., . . . Rieksts, G. (2022). Sea buckthorn (Hippophae rhamnoides) waste biomass after harvesting as a source of valuable biologically active compounds with nutraceutical and antibacterial potential. Plants, 11(5), 642.
42. Jaśniewska, A., & Diowksz, A. (2021). Wide spectrum of active compounds in sea buckthorn (Hippophae rhamnoides) for disease prevention and food production. Antioxidants, 10(8), 1279.
43. Jastrząb, A. & Skrzydlewska, E. 2019. Composition and biomedical relevance of sea buckthorn. Acta Poloniae Pharmaceutica-Drug Research, 76, 959-969.
44. Kumari, S., & Sharma, S. P. (2021). Effect of Sea buckthorn in preventing cardiovascular diseases in human beings. J Cardiovasc. Dis. Res, 12(6), 215-224.
45. Lange, K. W. (2020). Omega-3 fatty acids and mental health. Global Health Journal, 4(1), 18-30.
46. Lee, Y. H., Jang, H. J., Park, K. H., Kim, S.-H., Kim, J. K., Kim, J.-C., . . . Kim, K. H. (2021). Phytochemical analysis of the fruits of sea buckthorn (Hippophaë rhamnoides): Identification of organic acid derivatives. Plants, 10(5), 860.
47. Li, M., Hu, J., Yang, M., Yang, J., Zhang, Q., Zubarev, Y. A., . . . Bi, Y. (2022). Quality attributes and dielectric properties of sea buckthorn berries under differing freezing regimes and their interrelationships. Foods, 11(23), 3825.
48. Li, Y., Li, P., Yang, K., He, Q., Wang, Y., Sun, Y., . . . Xiao, P. (2021). Impact of drying methods on phenolic components and antioxidant activity of sea Buckthorn (Hippophae rhamnoides L.) berries from different varieties in China. Molecules, 26(23), 7189.
49. Device-Measured Physical Activity and Sedentary Behavior in Relation to Cardiovascular Diseases and All-Cause Mortality: Systematic Review and Meta-Analysis of Prospective Cohort Studies. AJPM focus, 2(1), 100054.
50. Liu, C.-H., Hsu, H.-J., Tseng, T.-L., Lin, T.-J., Weng, W.-H., Chen, M.-F., & Lee, T. J.-F. (2020). COMT- catalyzed palmitic acid methyl ester biosynthesis in perivascular adipose tissue and its potential role against hypertension. Journal of Pharmacology and Experimental Therapeutics, 373(2), 175- 183.
51. Liu, S., Xiao, P., Kuang, Y., Hao, J., Huang, T., & Liu, E. (2021). Flavonoids from sea buckthorn: A review on phytochemistry, pharmacokinetics and role in metabolic diseases. Journal of Food Biochemistry, 45(5), e13724.
52. LÕUGAS, T. 2006. Study on physico-chemical properties and some bioactive compounds of sea buckthorn (Hippophae rhamnoides L.), TUT Press Tallinn, Estonia.
53. Markkinen, N., Laaksonen, O., Nahku, R., Kuldjärv, R., & Yang, B. (2019). Impact of lactic acid fermentation on acids, sugars, and phenolic compounds in black chokeberry and sea buckthorn juices. Food Chemistry, 286, 204-215.
54. Melissa Petitto, R. (2020). Adaptogens: Chartwell Books.
55. Mezey, J., Hegedűs, O., Mezeyová, I., Szarka, K., & Hegedűsová, A. (2022). Thermal treatment influence on selected nutritional values of common sea Buckthorn (Hyppophae rhamnoides) juice. Agronomy, 12(8), 1834.
56. Mihalcea, L., Turturică, M., Cucolea, E. I., Dănilă, G.-M., Dumitrașcu, L., Coman, G., Constantin, O. E., Grigore-Gurgu, L. & Stănciuc, N. 2021. CO2 supercritical fluid extraction of oleoresins from sea buckthorn pomace: Evidence of advanced bioactive profile and selected functionality. Antioxidants, 10, 1681.
57. Moore, E. M., Wagner, C., & Komarnytsky, S. (2020). The enigma of bioactivity and toxicity of botanical oils for skin care. Frontiers in Pharmacology, 11, 785.
58. Moskalets, Т., Vovkohon, А., Ovezmyradova, O., & Pеlеkhаtyi, V. (2021). Sea buckthorn: New promising varieties and using their berries for the manufacture of functional products. Ukrainian Journal of Ecology, 11(2), 137-143.
59. Mu, Y., Tao, C., Yuan, W., & Lv, Z.-l. (2022). Sea buckthorn leaf l-quebrachitol extract for improved glucose and lipid metabolism in insulin resistant HepG2 Cells. Bioresources, 17(1), 527.
60. Mulati, A., Ma, S., Zhang, H., Ren, B., Zhao, B., Wang, L., . . . Sair, A. T. (2020). Sea-buckthorn flavonoids alleviate high-fat and high-fructose diet-induced cognitive impairment by inhibiting insulin resistance and neuroinflammation. Journal of agricultural and food chemistry, 68(21), 5835- 5846.
61. Netreba, N., Sandulachi, E., Macari, A., Popa, S., Ribintev, I., Sandu, I., . . . Dianu, I. (2024). A Study on the Fruiting and Correlation between the Chemical Indicators and Antimicrobial Properties of Hippophae rhamnoides L. Horticulturae, 10(2), 137.
62. Nour, V., Panaite, T. D., Corbu, A. R., Ropota, M., & Turcu, R. P. (2021). Nutritional and Bioactive Compounds in Dried Sea-Buckthorn Pomace. Erwerbs-Obstbau, 63(1).
63. Nour, V., PANAITE, T. D., CORBU, A. R., ROPOTA, M. & TURCU, R. P. 2021. Nutritional and Bioactive Compounds in Dried Sea-Buckthorn Pomace. Erwerbs-Obstbau, 63.
64. Park, K. H., Hong, J.-H., Kim, S.-H., Kim, J.-C., Kim, K. H., & Park, K.-M. (2022). Anti-osteoporosis effects of the fruit of sea buckthorn (Hippophae rhamnoides) through promotion of osteogenic differentiation in ovariectomized mice. Nutrients, 14(17), 3604.
65. Pariyani, R., Kortesniemi, M., Liimatainen, J., Sinkkonen, J. & Yang, B. 2020. Untargeted metabolic fingerprinting reveals impact of growth stage and location on composition of sea buckthorn (Hippophaë rhamnoides) leaves. Journal of Food Science, 85, 364-373.
66. Pundir, S., Garg, P., Dviwedi, A., Ali, A., Kapoor, V., Kapoor, D., . . . Negi, P. (2021). Ethnomedicinal uses, phytochemistry and dermatological effects of Hippophae rhamnoides L.: A review. Journal of ethnopharmacology, 266, 113434.
67. Alternative pathways leading to ascorbate biosynthesis in plants: lessons from the last 25 years.
68. Journal of Experimental Botany, 75(9), 2644-2663.
69. Raghavan, A. K., Raghavan, S. K., Khanum, F., Shivanna, N. & Singh, B. A. 2008. Effect of sea buckthorn leaves based herbal formulation on hexachlorocyclohexane—induced oxidative stress in rats. Journal of dietary supplements, 5, 33-46.
70. Rashid, S., Arif, A., Tabasum, A., Zain, H., Ehsan, S., & Rahman, M. S. U. (2020). 98. Sea buckthorn Hippophae rhamnoides a non-conventional source of edible oil. Pure and Applied Biology (PAB), 9(1), 1040-1048.
71. Ren, R., Li, N., Su, C., Wang, Y., Zhao, X., Yang, L., . . . Ma, X. (2020). The bioactive components as well as the nutritional and health effects of sea buckthorn. RSC advances, 10(73), 44654-44671.
72. Roman, D., Constantin, O. E., Stănciuc, N. & Râpeanu, G. 2020. Bioactive compounds and antioxidant activitity in different extracts of sea buckthorn. The Annals of the University Dunarea de Jos of Galati. Fascicle VI-Food Technology, 44, 178-192.
73. Sandulachi, E., Macari, A., Cojocari, D., Balan, G., Popa, S., Turculeț, N., . . . Sturza, R. (2022).
74. Antimicrobial properties of sea buckthorn grown in the Republic of Moldova. Journal of Engineering Sciences(1), 164-175.
75. Sanwal, N., Mishra, S., Sahu, J. K., & Naik, S. (2022). Effect of ultrasound-assisted extraction on efficiency, antioxidant activity, and physicochemical properties of sea buckthorn (Hippophae salicipholia) seed oil. LWT, 153, 112386.
76. Schubertova, S., Krepsova, Z., Janotkova, L., Potočňáková, M., & Kreps, F. (2021). Exploitation of sea buckthorn fruit for novel fermented foods production: a review. Processes, 9(5), 749.
77. Segliņa, D., Krasnova, I., Grygier, A., Radziejewska‐Kubzdela, E., Rudzińska, M. & Górnaś, P. 2021. Unique bioactive molecule composition of sea buckthorn (Hippophae rhamnoides L.) oils obtained from the peel, pulp, and seeds via physical “solvent‐free” approaches. Journal of the American Oil Chemists' Society, 98, 1009-1020.
78. Shah, R. K., Idate, A., & Poorva, V. U. (2021). Comprehensive review on sea buckthorn: Biological activity and its potential uses. Pharma Innov, 10, 942-953.
79. Sharma, B., Arora, S., Sahoo, D., & Deswal, R. (2020). Comparative fatty acid profiling of Indian seabuckthorn showed altitudinal gradient dependent species-specific variations. Physiology and Molecular Biology of Plants, 26, 41-49.
80. Sharma, D. & Singh, N. 2017. Sea buckthorn. Hippophae species, 837-858.
81. Siddalingaswamy, M. & Khanum, F. 2010. Hypolipidemic and antioxidant effects of seabuckthorn leaf based herbal formulation. Int J Pharm Biol Sci Arch, 1, 457-466.
82. Shen, C., Wang, T., Guo, F., Sun, K., Wang, B., Wang, J., . . . Chen, Y. (2021). Structural characterization and intestinal protection activity of polysaccharides from Sea buckthorn (Hippophae rhamnoides L.) berries. Carbohydrate polymers, 274, 118648.
83. Singh, A., Ansari, V., Haider, F., Akhtar, J., & Ahsan, F. (2020). A Review on Topical preparation of Herbal Drugs used in Liposomal delivery against Ageing. Research Journal of Pharmacology and Pharmacodynamics, 12(1), 5-11.
84. Singh, V. (2022). Global Distribution of Seabuckthorn (Hippophae Sp.) Resources and Their Utilization The Seabuckthorn Genome (pp. 345-368): Springer.
85. Solà Marsiñach, M., & Cuenca, A. P. (2019). The impact of sea buckthorn oil fatty acids on human health. Lipids in Health and Disease, 18, 1-11.
86. Tereshchuk, L., Starovoytova, K., Babich, O., Dyshlyuk, L., Sergeeva, I., Pavsky, V., . . . Prosekov, A. (2020). Sea buckthorn and rosehip oils with chokeberry extract to prevent hypercholesterolemia in mice caused by a high-fat diet in vivo. Nutrients, 12(10), 2941.
87. Tkacz, K., Chmielewska, J., Turkiewicz, I. P., Nowicka, P., & Wojdyło, A. (2020). Dynamics of changes in organic acids, sugars and phenolic compounds and antioxidant activity of sea buckthorn and sea buckthorn-apple juices during malolactic fermentation. Food Chemistry, 332, 127382.
88. Tkacz, K., Gil‐Izquierdo, Á., Medina, S., Turkiewicz, I. P., Domínguez‐Perles, R., Nowicka, P., & Wojdyło, A. (2022). Phytoprostanes, phytofurans, tocopherols, tocotrienols, carotenoids and free amino acids and biological potential of sea buckthorn juices. Journal of the Science of Food and Agriculture, 102(1), 185-197.
89. Tomar, A., Kaushik, S., Arya, D., & Bhatia, J. (2019). CARDIOPROTECTIVE EFFECT OF SEABUCKTHORN OIL ON ISOPROTERENOL-INDUCED MYOCARDIAL INFARCTION IN DIABETIC RATS. Journal of
90. Hypertension, 37, e175.
91. Topală, C. M., Mazilu, I. C., Vulpe, M., & Vîjan, L. E. (2020). Quality study of fruits and extracts from six romanian sea buckthorn varieties. Current Trends in Natural Sciences, 9(17), 273-283.
92. Tudor, C., Bohn, T., Iddir, M., Dulf, F. V., Focşan, M., Rugină, D. O. & Pintea, A. 2019. Sea buckthorn oil as a valuable source of bioaccessible xanthophylls. Nutrients, 12, 76.
93. ul Baseer, N., Hafeez, A., Sohail, S. M., Ijaz, M., Ullah, F., Salim, M., . . . Khan, S. (2020). Scholars Journal of Agriculture and Veterinary Sciences.
94. Visan, S., Soritau, O., Tatomir, C., Baldasici, O., Balacescu, L., Balacescu, O., . . . Pintea, A. (2023). The bioactive properties of carotenoids from lipophilic sea buckthorn extract (Hippophae rhamnoides L.) in breast cancer cell lines. Molecules, 28(11), 4486.
95. Wang, K., Xu, Z., & Liao, X. (2022). Bioactive compounds, health benefits and functional food products of sea buckthorn: A review. Critical Reviews in Food Science and Nutrition, 62(24), 6761-6782.
96. Wang, N., Wen, X., Gao, Y., Lu, S., Li, Y., Shi, Y. & Yang, Z. 2022b. Identification and characterization of the bioactive polyphenols and volatile compounds in sea buckthorn leaves tea together with antioxidant and α-glucosidase inhibitory activities. Frontiers in Nutrition, 9, 890486.
97. Xiao, P.-t., Liu, S.-y., Kuang, Y.-j., Jiang, Z.-m., Lin, Y., Xie, Z.-s., & Liu, E.-H. (2021). Network pharmacology analysis and experimental validation to explore the mechanism of sea buckthorn flavonoids on hyperlipidemia. Journal of ethnopharmacology, 264, 113380.
98. Xin, Y., Yang, J., Zhao, S., Chen, K., Zhao, Y., Zhang, T., & Zhang, J. (2022). Sea buckthorn (Hippophae rhamnoides L.) oil exhibits antifungal activity against Aspergillus flavus via disrupting mitochondrial function. Czech Journal of Food Sciences, 40(3).
99. Yan, H., Bie, W., Cui, F.-Y., Feng, X., Qi, H.-M., Li, Z.-Y., & Zhang, Z.-H. (2021). Analysis of carotenoids content in sea buckthorn by high performance liquid chromatography.
100. Zargar, R., Raghuwanshi, P., Koul, A. L., Rastogi, A., Khajuria, P., Wahid, A., & Kour, S. (2022).
101. Hepatoprotective effect of seabuckthorn leaf-extract in lead acetate-intoxicated Wistar rats.
102. Drug and Chemical Toxicology, 45(1), 476-480.
103. Zhang, D., Yang, N., Dong, J., Wang, C., Li, Q., Wang, R., . . . Ma, Y. (2022). Prediction of the sea buckthorn AQP gene structure and its spatiotemporal expression pattern under drought stress. Journal of Plant Biochemistry and Biotechnology, 1-11.
104. Zhang, J., Zhou, H.-C., He, S.-B., Zhang, X.-F., Ling, Y.-H., Li, X.-Y., . . . Hou, D.-D. (2021). The
105. immunoenhancement effects of sea buckthorn pulp oil in cyclophosphamide-induced immunosuppressed mice. Food & Function, 12(17), 7954-7963.
106. Zhong, M., Zhao, S., Xie, J., & Wang, Y. (2022). Molecular and Cellular Mechanisms of the Anti-oxidative Activity of Seabuckthorn (Hippophae rhamnoides L.). The Seabuckthorn Genome, 301-313.
107. Zhu, Y., Minovic, I., Pranger, I., Navis, G., Bakker, S., & Riphagen, I. (2021). Circulating Plasma Omega-7 Monounsaturated Fatty Acids (Cis-Vaccenic Acid and Palmitoleic Acid) Are Related to All-Cause Mortality: The Lifelines Fatty Acids Cohort Study. Current Developments in Nutrition, 5, 532.
2. Ahani, H., & Attaran, S. (2022). Therapeutic potential of Seabuckthorn (Hippophae rhamnoides L.) in medical sciences. Cellular, Molecular and Biomedical Reports, 2(1), 22-32.
3. Akhter, P., Bhatti, T. Y., Shafiq, I., Jamil, F., Nazar, R., Nazir, M. S., . . . Park, Y. (2023). Antioxidant activity of sea buckthorn (Hippophae rhamnoides) seed oil extracted using various organic solvents.
4. Korean Journal of Chemical Engineering, 40(12), 2914-2920.
5. Anchidin, B.-G., Manoliu, D.-R., Ciobotaru, M.-C., Ciobanu, M. M., Gucianu, I., Sandu, G.-A., & Boișteanu, P. C. (2023). DEVELOPMENT OF A FUNCTIONAL MEAT PRODUCT WITH SEA BUCKTHORN OIL AND ANALYSIS OF ITS SENSORY AND PHYSICOCHEMICAL QUALITY. Scientific
6. Papers. Series D. Animal Science, 66(1).
7. Antache, A., Petrea, S.-M., Simionov, I.-A., Nica, A., Cristea, V., Georgescu, P. L., . . . Ciobîcă, A. (2023). EFFECT OF DIETARY SUPPLEMENTATION OF Nile tilapia WITH SEA BUCKTHORN AND VITAMIN E ON THE HEMATOLOGICAL AND SERUM BIOCHEMICAL INDICES. Scientific Papers.
8. Series D. Animal Science, 66(2).
9. Ao, X., Mu, Y., Xie, S., Meng, D., Zheng, Y., Meng, X., & Lv, Z. (2022). Impact of UHT processing on volatile components and chemical composition of sea buckthorn (Hippophae rhamnoides) pulp: A prediction of the biochemical pathway underlying aroma compound formation. Food Chemistry, 390, 133142.
10. Arif, S., Ahmed, H. M., Attacha, S., Attia, K. A., Mohammed, A. A., Ishaq, S., . . . Yang, S. H. (2024). Molecular Characterization and Comparative Transcriptomic Analysis of Hr-Lcyb and Hr-Psy Genes for Carotenoids Synthesis in Sea Buckthorn (Hippophae rhamnoides L.). Journal of Soil Science and Plant Nutrition, 1-12.
11. Attri, S., & Goel, G. (2020). Sea Buckthorn Berries: A Richer Source of Nutrition and Potential Health Benefits Asian Berries (pp. 221-237): CRC Press.
12. Balta, I., Stef, L., Pet, I., Iancu, T., Stef, D. & Corcionivoschi, N. 2021. Essential fatty acids as biomedicines in cardiac health. Biomedicines, 9, 1466.
13. Barkhuu, B., Lodonjav, M., Ganzorig, O., & Tumurtogoo, N. (2021). The Physicochemical Composition of Sea Buckthorn (Hippophae rhamnoides L) Oil and Its Treatment Characteristics. Paper presented at the 5th International Conference on Chemical Investigation and Utilization of Natural Resource (ICCIUNR-2021).
14. Bartish, I. V., & Thakur, R. (2022). Genetic diversity, evolution, and biogeography of seabuckthorn The Seabuckthorn Genome (pp. 23-66): Springer.
15. Bass, V. L., Soukup, J. M., Ghio, A. J., & Madden, M. C. (2020). Oleic acid and derivatives affect human endothelial cell mitochondrial function and vasoactive mediator production. Lipids in Health and Disease, 19, 1-9.
16. Bruno, G. M., Dovera, F., Ciccarone, A., & Colombo, G. L. (2022). Overview of Nutraceuticals and Cardiometabolic Diseases following Socio-Economic Analysis. Endocrines, 3(2), 255-295.
17. Cavak, N., Gümüştaş, M. & Demirci Cekic, S. 2022. The Protective Role of Hippophae rhamnoides L. on Rat Brain and Liver Tissues Exposed to Cold Plus Immobilization Stress Model. Turkish Neurosurgery, 32.
18. CHAO, C.-T., YEH, H.-Y., TSAI, Y.-T., CHUANG, P.-H., YUAN, T.-H., HUANG, J.-W. & CHEN, H.-W. 2019. Natural and non-natural antioxidative compounds: potential candidates for treatment of vascular calcification. Cell Death Discovery, 5, 145.
19. Chen, A., Feng, X., Dorjsuren, B., Chimedtseren, C., Damda, T.-A., & Zhang, C. (2023). Traditional food, modern food and nutritional value of Sea buckthorn (Hippophae rhamnoides L.): A review.
20. Journal of Future Foods, 3(3), 191-205.
21. Chen, K., Zhou, F., Zhang, J., Li, P., Zhang, Y., & Yang, B. (2022). Dietary supplementation with sea buckthorn berry puree alters plasma metabolomic profile and gut microbiota composition in hypercholesterolemia population. Foods, 11(16), 2481.
22. Ciesarová, Z., Murkovic, M., Cejpek, K., Kreps, F., Tobolková, B., Koplík, R., . . . Panovská, Z. (2020). Why is sea buckthorn (Hippophae rhamnoides L.) so exceptional? A review. Food Research International, 133, 109170.
23. Criste, A., Urcan, A. C., Bunea, A., Pripon Furtuna, F. R., Olah, N. K., Madden, R. H. & Corcionivoschi, N. 2020. Phytochemical composition and biological activity of berries and leaves from four Romanian sea buckthorn (Hippophae rhamnoides L.) varieties. Molecules, 25, 1170.
24. Čulina, P., Balbino, S., Jokić, S., Dragović-Uzelac, V., & Pedisić, S. (2024). Efficiency of Supercritical CO2 and Ultrasound-Assisted Extraction Techniques for Isolation of Bioactive Molecules from Sea Buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) Berry Oils and Cakes. Processes, 12(4), 698.
25. Dienaitė, L., Pukalskas, A., Pukalskienė, M., Pereira, C. V., Matias, A. A. & Venskutonis, P. R. 2020. Phytochemical composition, antioxidant and antiproliferative activities of defatted sea buckthorn (Hippophaë rhamnoides L.) berry pomace fractions consecutively recovered by pressurized ethanol and water. Antioxidants, 9, 274.
26. Ding, J., Ruan, C., Guan, Y., Li, H., Du, W., Lu, S., . . . Chen, Y. (2022). Nontargeted metabolomic and multigene expression analyses reveal the mechanism of oil biosynthesis in sea buckthorn berry pulp rich in palmitoleic acid. Food Chemistry, 374, 131719.
27. Dong, K., Binosha Fernando, W. M., Durham, R., Stockmann, R., & Jayasena, V. (2023). Nutritional value, health-promoting benefits and food application of sea buckthorn. Food Reviews International, 39(4), 2122-2137.
28. Du, L., Liu, Y., Wan, L., Chen, C., & Fan, G. (2020). Seabuckthorn Berries Attenuate Pulmonary Vascular Hyperpermeability in Lipopolysaccharide-induced Acute Lung Injury in Mice.
29. Du, W., Ding, J., Lu, S., Wen, X., Hu, J., & Ruan, C. (2022). Identification of the key flavonoid and lipid synthesis proteins in the pulp of two sea buckthorn cultivars at different developmental stages. BMC Plant Biology, 22(1), 299.
30. Dudau, M., Codrici, E., Tarcomnicu, I., Mihai, S., Popescu, I. D., Albulescu, L., . . . Rambu, D. (2021). A fatty acid fraction purified from sea buckthorn seed oil has regenerative properties on normal skin cells. Frontiers in Pharmacology, 12, 737571.
31. Dupak, R., Hrnkova, J., Simonova, N., Kovac, J., Ivanisova, E., Kalafova, A., Schneidgenova, M., Prnova, M. S., Brindza, J. & Tokarova, K. 2022. The consumption of sea buckthorn (Hippophae rhamnoides L.) effectively alleviates type 2 diabetes symptoms in spontaneous diabetic rats. Research in veterinary science, 152, 261-269.
32. El-Sohaimy, S. A., Shehata, M. G., Mathur, A., Darwish, A. G., Abd El-Aziz, N. M., Gauba, P., & Upadhyay, P. (2022). Nutritional evaluation of sea buckthorn “Hippophae rhamnoides” berries and the pharmaceutical potential of the fermented juice. Fermentation, 8(8), 391.
33. Farag, M. A., & Gad, M. Z. (2022). Omega-9 fatty acids: Potential roles in inflammation and cancer management. Journal of Genetic Engineering and Biotechnology, 20(1), 48.
34. Galitsyn, G., Lomovskiy, I., & Podgorbunskikh, E. (2023). Seasonal and Geographic Variation in Serotonin Content in Sea Buckthorn. Plant Foods for Human Nutrition, 78(1), 186-192.
35. Gâtlan, A.-M., & Gutt, G. (2021). Sea buckthorn in plant based diets. An analytical approach of sea buckthorn fruits composition: Nutritional value, applications, and health benefits. International journal of environmental research and public health, 18(17), 8986.
36. Gâtlan, A.-M. & Gutt, G. 2021. Sea buckthorn in plant based diets. An analytical approach of sea buckthorn fruits composition: Nutritional value, applications, and health benefits. International journal of environmental research and public health, 18, 8986
37. Green, R. C. 2007. Physicochemical properties and phenolic composition of selected Saskatchewan fruits: buffaloberry, chokecherry and sea buckthorn. University of Saskatchewan.
38. Guo, R., Chang, X., Guo, X., Brennan, C. S., Li, T., Fu, X. & Liu, R. H. 2017. Phenolic compounds, antioxidant activity, antiproliferative activity and bioaccessibility of Sea buckthorn (Hippophaë rhamnoides L.) berries as affected by in vitro digestion. Food & function, 8, 4229-4240.
39. Hao, W., He, Z., Zhu, H., Liu, J., Kwek, E., Zhao, Y., . . . Chen, Z.-Y. (2019). Sea buckthorn seed oil reduces blood cholesterol and modulates gut microbiota. Food & Function, 10(9), 5669-5681.
40. Ibrahim, I., Shalaby, A., Abdallah, H., El-Zohairy, N. & Bahr, H. 2020. Immunomodulatory and anti-angiogenic properties of Linum usitatissium (flaxseed) seeds ethanolic extract in atherogenic diet treated rats. Adv. Anim. Vet. Sci, 8, 18-25.
41. Janceva, S., Andersone, A., Lauberte, L., Bikovens, O., Nikolajeva, V., Jashina, L., . . . Rieksts, G. (2022). Sea buckthorn (Hippophae rhamnoides) waste biomass after harvesting as a source of valuable biologically active compounds with nutraceutical and antibacterial potential. Plants, 11(5), 642.
42. Jaśniewska, A., & Diowksz, A. (2021). Wide spectrum of active compounds in sea buckthorn (Hippophae rhamnoides) for disease prevention and food production. Antioxidants, 10(8), 1279.
43. Jastrząb, A. & Skrzydlewska, E. 2019. Composition and biomedical relevance of sea buckthorn. Acta Poloniae Pharmaceutica-Drug Research, 76, 959-969.
44. Kumari, S., & Sharma, S. P. (2021). Effect of Sea buckthorn in preventing cardiovascular diseases in human beings. J Cardiovasc. Dis. Res, 12(6), 215-224.
45. Lange, K. W. (2020). Omega-3 fatty acids and mental health. Global Health Journal, 4(1), 18-30.
46. Lee, Y. H., Jang, H. J., Park, K. H., Kim, S.-H., Kim, J. K., Kim, J.-C., . . . Kim, K. H. (2021). Phytochemical analysis of the fruits of sea buckthorn (Hippophaë rhamnoides): Identification of organic acid derivatives. Plants, 10(5), 860.
47. Li, M., Hu, J., Yang, M., Yang, J., Zhang, Q., Zubarev, Y. A., . . . Bi, Y. (2022). Quality attributes and dielectric properties of sea buckthorn berries under differing freezing regimes and their interrelationships. Foods, 11(23), 3825.
48. Li, Y., Li, P., Yang, K., He, Q., Wang, Y., Sun, Y., . . . Xiao, P. (2021). Impact of drying methods on phenolic components and antioxidant activity of sea Buckthorn (Hippophae rhamnoides L.) berries from different varieties in China. Molecules, 26(23), 7189.
49. Device-Measured Physical Activity and Sedentary Behavior in Relation to Cardiovascular Diseases and All-Cause Mortality: Systematic Review and Meta-Analysis of Prospective Cohort Studies. AJPM focus, 2(1), 100054.
50. Liu, C.-H., Hsu, H.-J., Tseng, T.-L., Lin, T.-J., Weng, W.-H., Chen, M.-F., & Lee, T. J.-F. (2020). COMT- catalyzed palmitic acid methyl ester biosynthesis in perivascular adipose tissue and its potential role against hypertension. Journal of Pharmacology and Experimental Therapeutics, 373(2), 175- 183.
51. Liu, S., Xiao, P., Kuang, Y., Hao, J., Huang, T., & Liu, E. (2021). Flavonoids from sea buckthorn: A review on phytochemistry, pharmacokinetics and role in metabolic diseases. Journal of Food Biochemistry, 45(5), e13724.
52. LÕUGAS, T. 2006. Study on physico-chemical properties and some bioactive compounds of sea buckthorn (Hippophae rhamnoides L.), TUT Press Tallinn, Estonia.
53. Markkinen, N., Laaksonen, O., Nahku, R., Kuldjärv, R., & Yang, B. (2019). Impact of lactic acid fermentation on acids, sugars, and phenolic compounds in black chokeberry and sea buckthorn juices. Food Chemistry, 286, 204-215.
54. Melissa Petitto, R. (2020). Adaptogens: Chartwell Books.
55. Mezey, J., Hegedűs, O., Mezeyová, I., Szarka, K., & Hegedűsová, A. (2022). Thermal treatment influence on selected nutritional values of common sea Buckthorn (Hyppophae rhamnoides) juice. Agronomy, 12(8), 1834.
56. Mihalcea, L., Turturică, M., Cucolea, E. I., Dănilă, G.-M., Dumitrașcu, L., Coman, G., Constantin, O. E., Grigore-Gurgu, L. & Stănciuc, N. 2021. CO2 supercritical fluid extraction of oleoresins from sea buckthorn pomace: Evidence of advanced bioactive profile and selected functionality. Antioxidants, 10, 1681.
57. Moore, E. M., Wagner, C., & Komarnytsky, S. (2020). The enigma of bioactivity and toxicity of botanical oils for skin care. Frontiers in Pharmacology, 11, 785.
58. Moskalets, Т., Vovkohon, А., Ovezmyradova, O., & Pеlеkhаtyi, V. (2021). Sea buckthorn: New promising varieties and using their berries for the manufacture of functional products. Ukrainian Journal of Ecology, 11(2), 137-143.
59. Mu, Y., Tao, C., Yuan, W., & Lv, Z.-l. (2022). Sea buckthorn leaf l-quebrachitol extract for improved glucose and lipid metabolism in insulin resistant HepG2 Cells. Bioresources, 17(1), 527.
60. Mulati, A., Ma, S., Zhang, H., Ren, B., Zhao, B., Wang, L., . . . Sair, A. T. (2020). Sea-buckthorn flavonoids alleviate high-fat and high-fructose diet-induced cognitive impairment by inhibiting insulin resistance and neuroinflammation. Journal of agricultural and food chemistry, 68(21), 5835- 5846.
61. Netreba, N., Sandulachi, E., Macari, A., Popa, S., Ribintev, I., Sandu, I., . . . Dianu, I. (2024). A Study on the Fruiting and Correlation between the Chemical Indicators and Antimicrobial Properties of Hippophae rhamnoides L. Horticulturae, 10(2), 137.
62. Nour, V., Panaite, T. D., Corbu, A. R., Ropota, M., & Turcu, R. P. (2021). Nutritional and Bioactive Compounds in Dried Sea-Buckthorn Pomace. Erwerbs-Obstbau, 63(1).
63. Nour, V., PANAITE, T. D., CORBU, A. R., ROPOTA, M. & TURCU, R. P. 2021. Nutritional and Bioactive Compounds in Dried Sea-Buckthorn Pomace. Erwerbs-Obstbau, 63.
64. Park, K. H., Hong, J.-H., Kim, S.-H., Kim, J.-C., Kim, K. H., & Park, K.-M. (2022). Anti-osteoporosis effects of the fruit of sea buckthorn (Hippophae rhamnoides) through promotion of osteogenic differentiation in ovariectomized mice. Nutrients, 14(17), 3604.
65. Pariyani, R., Kortesniemi, M., Liimatainen, J., Sinkkonen, J. & Yang, B. 2020. Untargeted metabolic fingerprinting reveals impact of growth stage and location on composition of sea buckthorn (Hippophaë rhamnoides) leaves. Journal of Food Science, 85, 364-373.
66. Pundir, S., Garg, P., Dviwedi, A., Ali, A., Kapoor, V., Kapoor, D., . . . Negi, P. (2021). Ethnomedicinal uses, phytochemistry and dermatological effects of Hippophae rhamnoides L.: A review. Journal of ethnopharmacology, 266, 113434.
67. Alternative pathways leading to ascorbate biosynthesis in plants: lessons from the last 25 years.
68. Journal of Experimental Botany, 75(9), 2644-2663.
69. Raghavan, A. K., Raghavan, S. K., Khanum, F., Shivanna, N. & Singh, B. A. 2008. Effect of sea buckthorn leaves based herbal formulation on hexachlorocyclohexane—induced oxidative stress in rats. Journal of dietary supplements, 5, 33-46.
70. Rashid, S., Arif, A., Tabasum, A., Zain, H., Ehsan, S., & Rahman, M. S. U. (2020). 98. Sea buckthorn Hippophae rhamnoides a non-conventional source of edible oil. Pure and Applied Biology (PAB), 9(1), 1040-1048.
71. Ren, R., Li, N., Su, C., Wang, Y., Zhao, X., Yang, L., . . . Ma, X. (2020). The bioactive components as well as the nutritional and health effects of sea buckthorn. RSC advances, 10(73), 44654-44671.
72. Roman, D., Constantin, O. E., Stănciuc, N. & Râpeanu, G. 2020. Bioactive compounds and antioxidant activitity in different extracts of sea buckthorn. The Annals of the University Dunarea de Jos of Galati. Fascicle VI-Food Technology, 44, 178-192.
73. Sandulachi, E., Macari, A., Cojocari, D., Balan, G., Popa, S., Turculeț, N., . . . Sturza, R. (2022).
74. Antimicrobial properties of sea buckthorn grown in the Republic of Moldova. Journal of Engineering Sciences(1), 164-175.
75. Sanwal, N., Mishra, S., Sahu, J. K., & Naik, S. (2022). Effect of ultrasound-assisted extraction on efficiency, antioxidant activity, and physicochemical properties of sea buckthorn (Hippophae salicipholia) seed oil. LWT, 153, 112386.
76. Schubertova, S., Krepsova, Z., Janotkova, L., Potočňáková, M., & Kreps, F. (2021). Exploitation of sea buckthorn fruit for novel fermented foods production: a review. Processes, 9(5), 749.
77. Segliņa, D., Krasnova, I., Grygier, A., Radziejewska‐Kubzdela, E., Rudzińska, M. & Górnaś, P. 2021. Unique bioactive molecule composition of sea buckthorn (Hippophae rhamnoides L.) oils obtained from the peel, pulp, and seeds via physical “solvent‐free” approaches. Journal of the American Oil Chemists' Society, 98, 1009-1020.
78. Shah, R. K., Idate, A., & Poorva, V. U. (2021). Comprehensive review on sea buckthorn: Biological activity and its potential uses. Pharma Innov, 10, 942-953.
79. Sharma, B., Arora, S., Sahoo, D., & Deswal, R. (2020). Comparative fatty acid profiling of Indian seabuckthorn showed altitudinal gradient dependent species-specific variations. Physiology and Molecular Biology of Plants, 26, 41-49.
80. Sharma, D. & Singh, N. 2017. Sea buckthorn. Hippophae species, 837-858.
81. Siddalingaswamy, M. & Khanum, F. 2010. Hypolipidemic and antioxidant effects of seabuckthorn leaf based herbal formulation. Int J Pharm Biol Sci Arch, 1, 457-466.
82. Shen, C., Wang, T., Guo, F., Sun, K., Wang, B., Wang, J., . . . Chen, Y. (2021). Structural characterization and intestinal protection activity of polysaccharides from Sea buckthorn (Hippophae rhamnoides L.) berries. Carbohydrate polymers, 274, 118648.
83. Singh, A., Ansari, V., Haider, F., Akhtar, J., & Ahsan, F. (2020). A Review on Topical preparation of Herbal Drugs used in Liposomal delivery against Ageing. Research Journal of Pharmacology and Pharmacodynamics, 12(1), 5-11.
84. Singh, V. (2022). Global Distribution of Seabuckthorn (Hippophae Sp.) Resources and Their Utilization The Seabuckthorn Genome (pp. 345-368): Springer.
85. Solà Marsiñach, M., & Cuenca, A. P. (2019). The impact of sea buckthorn oil fatty acids on human health. Lipids in Health and Disease, 18, 1-11.
86. Tereshchuk, L., Starovoytova, K., Babich, O., Dyshlyuk, L., Sergeeva, I., Pavsky, V., . . . Prosekov, A. (2020). Sea buckthorn and rosehip oils with chokeberry extract to prevent hypercholesterolemia in mice caused by a high-fat diet in vivo. Nutrients, 12(10), 2941.
87. Tkacz, K., Chmielewska, J., Turkiewicz, I. P., Nowicka, P., & Wojdyło, A. (2020). Dynamics of changes in organic acids, sugars and phenolic compounds and antioxidant activity of sea buckthorn and sea buckthorn-apple juices during malolactic fermentation. Food Chemistry, 332, 127382.
88. Tkacz, K., Gil‐Izquierdo, Á., Medina, S., Turkiewicz, I. P., Domínguez‐Perles, R., Nowicka, P., & Wojdyło, A. (2022). Phytoprostanes, phytofurans, tocopherols, tocotrienols, carotenoids and free amino acids and biological potential of sea buckthorn juices. Journal of the Science of Food and Agriculture, 102(1), 185-197.
89. Tomar, A., Kaushik, S., Arya, D., & Bhatia, J. (2019). CARDIOPROTECTIVE EFFECT OF SEABUCKTHORN OIL ON ISOPROTERENOL-INDUCED MYOCARDIAL INFARCTION IN DIABETIC RATS. Journal of
90. Hypertension, 37, e175.
91. Topală, C. M., Mazilu, I. C., Vulpe, M., & Vîjan, L. E. (2020). Quality study of fruits and extracts from six romanian sea buckthorn varieties. Current Trends in Natural Sciences, 9(17), 273-283.
92. Tudor, C., Bohn, T., Iddir, M., Dulf, F. V., Focşan, M., Rugină, D. O. & Pintea, A. 2019. Sea buckthorn oil as a valuable source of bioaccessible xanthophylls. Nutrients, 12, 76.
93. ul Baseer, N., Hafeez, A., Sohail, S. M., Ijaz, M., Ullah, F., Salim, M., . . . Khan, S. (2020). Scholars Journal of Agriculture and Veterinary Sciences.
94. Visan, S., Soritau, O., Tatomir, C., Baldasici, O., Balacescu, L., Balacescu, O., . . . Pintea, A. (2023). The bioactive properties of carotenoids from lipophilic sea buckthorn extract (Hippophae rhamnoides L.) in breast cancer cell lines. Molecules, 28(11), 4486.
95. Wang, K., Xu, Z., & Liao, X. (2022). Bioactive compounds, health benefits and functional food products of sea buckthorn: A review. Critical Reviews in Food Science and Nutrition, 62(24), 6761-6782.
96. Wang, N., Wen, X., Gao, Y., Lu, S., Li, Y., Shi, Y. & Yang, Z. 2022b. Identification and characterization of the bioactive polyphenols and volatile compounds in sea buckthorn leaves tea together with antioxidant and α-glucosidase inhibitory activities. Frontiers in Nutrition, 9, 890486.
97. Xiao, P.-t., Liu, S.-y., Kuang, Y.-j., Jiang, Z.-m., Lin, Y., Xie, Z.-s., & Liu, E.-H. (2021). Network pharmacology analysis and experimental validation to explore the mechanism of sea buckthorn flavonoids on hyperlipidemia. Journal of ethnopharmacology, 264, 113380.
98. Xin, Y., Yang, J., Zhao, S., Chen, K., Zhao, Y., Zhang, T., & Zhang, J. (2022). Sea buckthorn (Hippophae rhamnoides L.) oil exhibits antifungal activity against Aspergillus flavus via disrupting mitochondrial function. Czech Journal of Food Sciences, 40(3).
99. Yan, H., Bie, W., Cui, F.-Y., Feng, X., Qi, H.-M., Li, Z.-Y., & Zhang, Z.-H. (2021). Analysis of carotenoids content in sea buckthorn by high performance liquid chromatography.
100. Zargar, R., Raghuwanshi, P., Koul, A. L., Rastogi, A., Khajuria, P., Wahid, A., & Kour, S. (2022).
101. Hepatoprotective effect of seabuckthorn leaf-extract in lead acetate-intoxicated Wistar rats.
102. Drug and Chemical Toxicology, 45(1), 476-480.
103. Zhang, D., Yang, N., Dong, J., Wang, C., Li, Q., Wang, R., . . . Ma, Y. (2022). Prediction of the sea buckthorn AQP gene structure and its spatiotemporal expression pattern under drought stress. Journal of Plant Biochemistry and Biotechnology, 1-11.
104. Zhang, J., Zhou, H.-C., He, S.-B., Zhang, X.-F., Ling, Y.-H., Li, X.-Y., . . . Hou, D.-D. (2021). The
105. immunoenhancement effects of sea buckthorn pulp oil in cyclophosphamide-induced immunosuppressed mice. Food & Function, 12(17), 7954-7963.
106. Zhong, M., Zhao, S., Xie, J., & Wang, Y. (2022). Molecular and Cellular Mechanisms of the Anti-oxidative Activity of Seabuckthorn (Hippophae rhamnoides L.). The Seabuckthorn Genome, 301-313.
107. Zhu, Y., Minovic, I., Pranger, I., Navis, G., Bakker, S., & Riphagen, I. (2021). Circulating Plasma Omega-7 Monounsaturated Fatty Acids (Cis-Vaccenic Acid and Palmitoleic Acid) Are Related to All-Cause Mortality: The Lifelines Fatty Acids Cohort Study. Current Developments in Nutrition, 5, 532.
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Mar 09, 2023
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Adil Iqbal, Abdul Jabbar, Hina Mumtaz, Faiza Rafique, Ayesha Shakir, Esha Arshad, Qurban Ali, Maaz Bin Nasim, & Muhammad Naveed Mushtaq. (2023). NUTRITIONAL AND MEDICINAL PROPERTIES OF SEA BUCKTHORN AND COMPREHENSIVE REVIEW OF ITS PHYTOCHEMICAL CONSTITUENTS AND HEALTH BENEFITS. Journal of Population Therapeutics and Clinical Pharmacology, 30(3), 1088-1111. https://doi.org/10.53555/ns0zf490
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Author Biographies
Adil Iqbal
Department of Pharmacy, Grand Asian University Sialkot
Abdul Jabbar
Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore
Hina Mumtaz
Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore
Faiza Rafique
Department of Pharmacy, University of Lahore, Lahore
Ayesha Shakir
Imran Idrees College of Pharmacy, Sialkot
Esha Arshad
Imran Idrees College of Pharmacy, Sialkot
Qurban Ali
Department of Pharmacy, Grand Asian University Sialkot
Maaz Bin Nasim
Green International University, Lahore
Muhammad Naveed Mushtaq
Department of Pharmacy, University of Lahore, Lahore
How to Cite
Adil Iqbal, Abdul Jabbar, Hina Mumtaz, Faiza Rafique, Ayesha Shakir, Esha Arshad, Qurban Ali, Maaz Bin Nasim, & Muhammad Naveed Mushtaq. (2023). NUTRITIONAL AND MEDICINAL PROPERTIES OF SEA BUCKTHORN AND COMPREHENSIVE REVIEW OF ITS PHYTOCHEMICAL CONSTITUENTS AND HEALTH BENEFITS. Journal of Population Therapeutics and Clinical Pharmacology, 30(3), 1088-1111. https://doi.org/10.53555/ns0zf490