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Abdul Jabbar
Iqbal Azhar
Shafi Muhammad
Shahlla Imam
Mohammad Arslan
Nagina Soomer Khan
Nisar Ahmad Shahwani
Muhammad Younis
Ghulam Mustafa
Abdul Qadir


Anti-diabetic, Anti-epileptic, Cardioprotective, Berchemia pakistanica


Berchemia pakistanica is a medicinal plant of Balochistan, used for treatment of various diseases intraditional medicine. In current study, preliminary phytochemical tests, FT-IR studies, determinationof the heavy metal concentrations, acute toxicity, anti-diabetic, anti-epileptic and cardioprotectiveactivitieswereevaluated.Inpreliminaryphytochemicaltests,alkaloids,saponins,flavonoids,glycosides, Terpenoids and tannins were present. In FT-IR studies presence of various functionalgroups were confirmed. The concentration of Se, Cr, Co, Sb and Mn were within the permitted limit.Up to dose of 5000 mg/kg B. pakistanica did not showed any sign of toxicity. B. pakistanica ethanolextractshowedsignificant(p<0.05)anti-diabeticeffectsandalloxaninduceddiabetes.B.pakistanicaethanol extract also showed significant (p<0.05) anti-epileptic effects in strychnine and picrotoxininducedanti-convulsantactivity.InCardioprotectiveactivityB.pakistanicaethanolextractproducedsignificant (p<0.05) protective effects. It is concluded that B. pakistanica showed significant anti-diabetic, anti-epileptic and cardioprotective activities and can be used as an alternative drug formanagementofEpilepsy,diabetes and asan cardioprotectiveagent.

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