ASSESSMENT OF LIVER FUNCTION TESTS IN CHILDREN WITH G6PD DEFICIENCY
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Keywords
G6PD deficiency, liver function tests, pediatric hepatology, enzyme markers, Indian children
Abstract
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common enzymopathies worldwide, with a significant prevalence in India. This study assesses liver function tests (LFTs) in Indian children diagnosed with G6PD deficiency to determine potential hepatic involvement. The study aims to analyze liver enzyme alterations, bilirubin levels, and other biochemical markers to understand their implications in managing affected children. A total of 200 children aged 1–12 years diagnosed with G6PD deficiency were included in this observational study, along with 200 age- and gender-matched healthy controls. Biochemical markers such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, alkaline phosphatase (ALP), and total protein levels were assessed. Results showed that G6PD-deficient children had significantly higher levels of ALT, AST, and total bilirubin compared to controls (p < 0.05). ALP and albumin levels remained comparable. The findings suggest mild hepatic involvement, possibly due to oxidative stress and hemolysis. Regular monitoring of LFTs in G6PD-deficient children is recommended, especially during oxidative stress episodes. Further studies with larger cohorts are needed to establish long-term hepatic outcomes in this population.
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Dr. Mohamed Rafi
Specialist Registrar, Dept. Of Neonatology, Latifa Women and Children Hospital, Dubai, UAE
Dr. Prakash Ignace Tete
Senior Specialist Registrar, Dept. Of Neonatology Latifa Women and Children Hospital, Dubai, UAE
Dr. Aswathy Devaki Satyan
Specialist Registrar, Dept. Of Neonatology, Latifa Women and Children Hospital, UAE
Dr. Sushma BJ
Professor and Head, Dept. of Biochemistry, National Institute of Medical Sciences, Jaipur