TRENDS IN LIPID PROFILE AND TRACE ELEMENTS IN METABOLIC SYNDROME
Main Article Content
Keywords
metabolic syndrome, lipid profile, trace elements, copper, zinc and iron.
Abstract
Introduction
Metabolic Syndrome (MetS) is a complex, multifaceted disorder characterized by a cluster of interconnected cardiovascular and metabolic risk factors. Derangements in lipid metabolism (hyperlipoproteinemias) and trace elements play crucial roles development of metabolic syndrome. The objective of the present study is to determine lipid profile patterns and trace element levels (copper, zinc, and iron) in subjects with MetS and without MetS.
Methods
A comparative cross-sectional study included 90 subjects with MetS and 90 subjects without MetS. Fasting venous blood sample was collected and analysed for the quantitative estimation of Lipid profile parameters (total cholesterol, triglycerides, LDL, HDL, VLDL), copper, zinc, and iron levels in fully automated dry chemistry analyser Vitros 5600 as per manufactures instructions.
Results
In the present study we found altered lipid profile parameters and trace elements levels (copper, zinc and iron) in subjects with MetS in contrast to subjects without MetS. The lipid alterations mainly included hypercholesterolemia, hypertriglyceridemia, elevated low density lipoproteins and decreased high density lipoproteins in MetS and also the trace elements showed significantly higher concentrations in MetS.
Conclusion
This study highlights the importance of considering lipid profiles and trace element levels in the diagnosis and management of MetS. Monitoring lipid profile, iron, copper, and zinc levels will aid in identifying individuals at possibility of progressing to MetS or its components. Early therapeutic interventions for hyperlipoproteinemias and addressing trace element imbalances through dietary modifications or supplementation may be a useful adjunctive therapy in managing MetS. Additional investigation is required to illuminate the mechanisms fundamental to trace element dysregulation in MetS and to explore potential therapeutic applications.
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Dr. Sunita Singh
Associate Professor, Dept. of Biochemistry, Mahatma Gandhi Medical College and Hospital, Jaipur
Dr. Sushma BJ
Professor and Head, Dept. of Biochemistry, National Institute of Medical Sciences and Research, Jaipur