EVALUATION OF CONSANGUINITY AS A RISK FACTOR FOR CONGENITAL HEART DISEASE IN PATIENTS WITH ADULT CONGENITAL HEART DISEASE AT TERTIARY CARE HOSPITAL IN PAKISTAN
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Keywords
Consanguinity, Congenital heart disease, Adult patients, Pakistan
Abstract
Objectives: To assess consanguinity as a potential risk factor for congenital heart disease in patients with adult congenital heart disease in a tertiary care hospital setting in Pakistan.
Materials and Methods: This is cross sectional study conducted in outpatient department of Pediatric Cardiology, National Institute of Cardiovascular Disease (NICVD), Karachi, Pakistan from November, 2022 to October, 2023. Patients with age equal and more than 18 years with CHD were enrolled. This study A predesign questionere were used to collect data. For statistical analysis we used SPSS Version 25.
Results: A total of 129 patients were enrolled. The mean age of the patients with congenital heart disease (CHD) was 25.74±9.77 years. Among the total enrolled CHD patients, 73 (56.6%) were male, and 65 (43.4%) were female. The history of CHD in the mother, father, and siblings was reported in 7 (5.4%), 5 (3.9%), and 7 (5.4%) cases, respectively. Additionally, 52 (40.3%) patients had a history of consanguinity in their parents' marriage.
Conclusion: The study's conclusion indicates that there is a heightened risk of Congenital Heart Diseases (CHDs) in adult patients associated with consanguinity in parental marriages.
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Aliya Kemal Ahsan
MBBS, FCPS Paediatrics, FCPS Paediatric Cardiology, Assistant Professor Paediatric Cardiology, National institute of cardiovascular diseases Karachi
Rumana Sangi
MBBS, FCPS Paediatrics, FCPS Paediatric Cardiology, Senior Registrar Paediatric Cardiology, National institute of Cardiovascular Diseases Karachi.
Ramchand
MBBS, FCPS Paediatrics, FCPS Paediatric Cardiology, Assistant Professor Paediatric Cardiology, National institute of cardiovascular diseases Karachi
Mohammad Mohsin
MBBS, FCPS Paediatrics, FCPS Paediatric Cardiology, Fellowship in Paediatric Electrophysiology, Assistant Professor Paediatric Cardiology, National institute of Cardiovascular Diseases Karachi
Mujeeb Ur Rehman
MBBS, FCPS Paediatrics, FCPS Paediatric Cardiology, Senior Registrar Paediatric Cardiology, National institute of Cardiovascular Diseases Karachi
Farah Jamil
MBBS, FCPS Paediatrics, Post Fellow Paeds Cardiology, National institute of Cardiovascular diseases Karachi
Muhammad Moin Ashraf
MBBS, MCPS (Healthcare System Management), Senior Medical Officer, CBC Elaj DHA Phase 2 Karachi
Haider Ali
MBBS, Diploma in Paediatrics, Child Specialist, RHQ Hospiatl Gilgit Pakistan
Abdul Sattar Shaikh
MBBS, FCPS Paediatrics, FCPS Paediatric Cardiology, Fellowship in Interventional Cardiology, Associate Professor Paediatric Cardiology, National institute of Cardiovascular Diseases Karachi