EXPLORING NEUROPHARMACOLOGICAL EFFECTS OF PRUNUS BRIGANTINA AND MANGIFERA INDICA FRUIT EXTRACTS: AN EXPERIMENTAL STUDY ON ANXIETY AND DEPRESSION IN MICE

Abstract

Traditional medicine and natural products have historically played a pivotal role in combating various ailments. With approximately 70% of the global population relying on herbal medicines for primary healthcare needs, these remedies represent an enduring reservoir of therapeutic compounds. Amidst this landscape, depression emerges as a multifaceted condition, intricately intertwined with neurotransmitter imbalances, often refractory to conventional treatments. Despite the prevalence of allopathic antidepressants, characterized by modest response rates and significant side effects, the exploration of alternative therapeutic modalities remains paramount. This study delves into the neuropharmacological effects of ethanolic fruit extracts from Prunus brigantina and Mangifera indica, shedding light on their potential to address depression and related disorders. Through meticulous experimentation involving behavioural assays, including the cage crossing test, open field test, head dip test, forced swimming test, stationary rod test and light and dark field test statistically significant outcomes (*P < 0.05, **P < 0.01) were observed. Intriguingly, Prunus brigantina exhibited anxiolytic and calming properties, contrasting with the stimulating effects of Mangifera indica. These findings not only underscore the intricate interplay between botanical extracts and behavioral responses but also offer promising avenues for the development of novel therapeutic interventions, bridging the chasm between traditional wisdom and contemporary pharmacology.