COMPARISON OF LABETALOL VERSUS LIDOCAINE IN ATTENUATION OF HEMODYNAMIC RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION

Abstract

Objective: To compare labetalol versus lidocaine in attenuation of hemodynamic response during laryngoscopy and endotracheal intubation.
Background: Endotracheal intubation and laryngoscopy are unpleasant stimuli that cause sympathomimetic reactions. Even though it's widely tolerated in healthy individuals, there could be potentially fatal consequences. Although lignocaine and benetacol reduce these reactions, they are linked to hypotension and bradycardia adverse effects.
Study design: A Randomized controlled trial
Place and Duration: This study was conducted in Liaquat University of Medical and Health Sciences Jamshoro from March 2023 to March 2024
Methodology: All patients aged 20-60 years of either gender scheduled for various general surgical procedures under endotracheal anesthesia having ASA status I & II were consecutively enrolled. Two groups LG (lignocaine group) and LB (Labetalol group) was made. Hemodynamic responses in terms of systolic blood pressure (SBP) and mean arterial pressure (MAP) was noted during laryngoscopy and 10 mins after endotracheal intubation.
Results: Out of 62 patients, Mean SBP after laryngoscopy was significantly higher among patients who were in Lignocaine group than in Labetalol group, i.e., 127.48 ±2.54 vs. 122.13 ±2.67 (p-value <0.001, 95% CI 4.03-6.68). Mean MAP after laryngoscopy was significantly higher among patients who were in Lignocaine group than in Labetalol group, i.e., 104.74 ±3.51 vs. 92.29 ±4.42 (p-value <0.001, 95% CI 10.42-14.48).
Conclusion: A significant difference in attenuation of hemodynamic response was observed in between labetalol versus lidocaine use during laryngoscopy and endotracheal intubation.