TREATMENT EVALUATION OF GENITAL CHLAMYDIA TRACHOMATIS INFECTION DURING PREGNANCY

Main Article Content

Shahana Wahid
Nausheen Hameed Siddiqui
Kamran Zaheer
Farah Owais
Khaola Tahreem Qaiser
Rida Islam
Javeria Javed
Wajeeha Ishrat

Keywords

Chlamydia trachomatis, Pregnant women, Clindamycin, Erythromycin, Azithromycin, Amoxicillin, Sexually transmitted infections, Infertility

Abstract

Background: Chlamydia trachomatis is an intracellular pathogenic bacterium whose solitary natural host is human. Ct is a sexually transmitted disease normally detected during pregnancy and thus has been associated with adverse pregnancy outcomes and also mother-to-child transmission can occur at the time of birth and may result in premature rupture of membranes, preterm birth, low birth weight, conjunctivitis, and pneumonia in infants if left untreated.


Aims and Objectives: The main objective of this review is to evaluate existing literature to determine potential benefits of antenatal treatment evaluation for treating genital chlamydia trachomatis infection during pregnancy to prevent adverse outcomes that leads to either neonatal or mother morbidity. The literature will also analyze the most efficacious antibiotic regimen to treat Chlamydia trachomatis infections in pregnancy, side effects of the treatment regimen and resistance.


Methodology: I have searched data from PubMed, Cochrane Library and Scopus till the end of February 2024. Only Randomized control trials that meet the inclusion criteria of antibiotics consider safe to consume during pregnancy for genital chlamydia trachomatis are Macrolides (Azithromycin, Erythromycin), Clindamycin and Amoxicillin compared with either placebo or no treatment or any alternative antibiotic treatment were included.


Results: Clindamycin proved somewhat the most successful treatment in eradicating Chlamydia trachomatis among pregnant women (95%) which significantly related to least treatment failure (5.2%) as compared to azithromycin, erythromycin and Amoxicillin. Among all of the Comparisons of Erythromycin with other antibiotic treatment like Amoxicillin, Clindamycin, Azithromycin the rate of GIT side effects associated to Erythromycin are significantly higher than others (27%).


Conclusion: In conclusion, the best antibiotic for treating C. trachomatis infections during pregnancy is Clindamycin. Clindamycin's characteristic pharmacokinetic profile enabled a high degree of patient compliance and a high success rate in eliminating the active infection with less gastrointestinal side effects.

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