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Saeeda Shaikh
Saima Gaffar
Samreen Memon
Farhana Rajpar
Khalida Depar
Pushpa Goswami


Fetus, Histological, Macrosomia, Placenta, Placental membrane


BACKGROUND: Currently the prevalence of diabetes mellitus (DM) among women of childbearing age is increasing with abnormal maternal glucose tolerance in 3- 10% of pregnancies. The placenta and placental membranes or amniochorionic membrane (ACM) are affected by DM during pregnancy produces variety of abnormalities which may results in disturbances in fetal growth and development.

OBJECTIVES: The aim of this study is to observe gross and microscopic changes in placenta and amniochorionic membrane in mothers with GDM and their correlation with fetal outcome.

MATERIALS AND METHOD: This Cross sectional study was conducted on 49 full term pregnant women with diagnosis GDM. After brief history the placenta along with its membrane was collected immediately after delivery. ACM were separated and collected after gross morphological examination, tissue is prepared for microscopic examination. Slides were observed under microscope and changes were noted. The data was entered and analyzed on SPSS-25

RESULTS: The placenta and placental membranes revealed significant changes in diabetes. The site of placental rupture in GDM placentae was precise; the placental insertion was most frequently circumvallate 38.8% with thick basement membrane. Macrosomia is significantly associated with abnormal ACM.

DISCUSSION: In GDM weight, thickness and diameter of placenta were increased. On microscopy fibrinoid necrosis, increased syncytial knots, trophoblastic basement membrane thickening, villous stromal fibrosis and villous edema was observed with strong correlation with fetal macrosomia.

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