SPECTRUM OF HISTOPATHOLOGICAL CHANGES IN RUPTURED TUBAL ECTOPIC PREGNANCY AND ITS ASSOCIATION WITH TUBERCULOSIS
Main Article Content
Keywords
Ectopic pregnancy, histopathological findings, ruptured fallopian tube, Tuberculosis
Abstract
Background: Ectopic pregnancy significantly contributes in maternal morbidity and mortality. Fallopian tube is the commonest site of ectopic pregnancy. Genital tuberculosis, which manifest as chronic pelvic pain, pelvic inflammatory infection, infertility, or ectopic pregnancy, affects a significant number of women in underdeveloped countries where tuberculosis is still a serious health concern.
Objective: The aim of this study is to observe Histopathological changes in ruptured fallopian tube and association of tuberculosis in ruptured tubal pregnancy as an etiological factor for ectopic pregnancy.
Method: This descriptive study was conducted on 45 cases of ectopic tubal pregnancy admitted in the department of OBG during the study period. Slides were studied for various histological changes.
Results: Histopathological findings of ruptured fallopian tubes revealed ruptured ectopic products of conception and few chorionic villi in 16 cases, chorionic villi with decidual tissue and hemorrhage found in 12 cases, focal mucosal/intramural patches of necrosis seen in 13 cases while, TB granuloma in 04 cases. Tubal walls found invaded by chorionic villi up to serosa in 32 cases while tubal invasion was up to smooth muscle layer in 13 patients.
Conclusion: This study found non-significant association with tuberculosis in ruptured tubal ectopic pregnancy.
References
2. Bharti P. A clinical study of incidence, management and outcome of ectopic pregnancy. Int. J. Heal. Clin. Res. 2020; 3 (11):239-44.
3. Pati BK. Ectopic pregnancy: one-year retrospective study on clinical, investigational and operative correlation in a tertiary care hospital. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2017;6(12):5519-23.
4. Sultana S, Asif HM, Akhtar N. Incidence rate and prevalence of major risk factors for ectopic pregnancy in the Pakistani population: mini-review. Asian Pacific Journal of Tropical Disease. 2015 1;5(3):246-50.
5. Jyothsna P, Devi V. A Study of Incidence, clinical presentation, risk factors and morbidity associated with ectopic pregnancy in CKM-Government maternity hospital Matwada Warangal. J Contemporary Med Dent. 2020;8(1):25-30.
6. Ashfaq S, Sultan S, Aziz S, Irfan SM, Hasan M, Siddique A. Ectopic pregnancy with tubal rupture: an analysis of 80 cases. Journal of Ayub Medical College Abbottabad. 2017 Apr 8;29(2):254-7.
7. Yahya SA. Evaluation of ectopic pregnancy in Al-Salam hospital in Mosul, Iraq. Iraq Medical Journal. 2020 Mar 26;4(1).
8. Chatterjee S, Bagchi B, Chowdhury RG, Dutta A. Latent Genital Tuberculosis–A Causative Factor for Ectopic Pregnancy-A Retrospective Analysis. AGE. 2020;21:25.
9. Gyamtsho S, Tenzin K, Choeda T, Lhaden K. Clinical profile of ectopic pregnancies in a national referral hospital in Bhutan: A two-year retrospective study.
10. Jehangir F, Hashmi R, Lateef TK, Zubair M, Tasleem A, Giani A, Ghaffar A, Usman J. Prevalence and outcomes of tuberculosis treatment in a primary care center in Karachi, Pakistan. Archives of Medicine. 2020;12(6):0-.
11. Kour KK, Allahabadia G, Singh M. Advances in diagnosis and management of female genital tuberculosis-A comprehensive review. Acta Sci Microbiol. 2019;2(6):138-44.
12. Kaur S, Santpur U, Mor S. The incidence detection of tuberculosis in patients with infertility and abnormal uterine bleed: a study in North Indian population. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2019 Aug 1;8(8):3041-7.
13. Mahmood MK. Ectopic Pregnancy; Causes and Management in Kerbala Maternity Hospital. Karbala Journal of Medicine. 2019;12(2).
14. Sahib MS, Mughir HA.Risk factors for ectopic pregnancy. risk.;7(15):2020.
15. Jadoon S, Qadir M, Khan SM. Ectopic Pregnancy: An Analysis of 54 Cases in A Tertiary Care Hospital of Mardan. Journal of The Society of Obstetricians and Gynaecologists of Pakistan. 2018;8(4):238-42.
16. Mahadevan LS, Park BU, Yeh IT. Grossing Issues in Ovarian and Fallopian Tube Pathology. AJSP: Reviews & Reports. 2020 Jul 1;25(4):174-80.
17. Rani S, Goswami P, Rajpar F, Awan S, Gul F. Clinical Analysis of Ectopic Pregnancy in a Tertiary Care Hospitals. J Liaquat Uni Med Health Sci. 2019; 18 (04):266-71.
18. Sowmya S, Priya R, Meenakshi P, Shwetha B. Study of trophoblasts and histological changes of fallopian tube in tubal pregnancy an anatomical considerations for its early rupture. Int J Anat Res. 2014;2(4):609-13.
19. Sharma JB, Roy KK, Pushparaj M, Kumar S, Malhotra N, Mittal S. Laparoscopic findings in female genital tuberculosis. Archives of gynecology and obstetrics. 2008 Oct 1;278(4):359-64.
20. Clement WF, Ijeoma NE, Ledee KP. Ectopic pregnancy in Rivers State University Teaching Hospital, Port Harcourt, southern Nigeria: a five-year review. World Journal of Advanced Research and Reviews. 2020;6(2):044-53.
21. Bai S, Sujatha R. A study of incidence, clinical presentation and risk factors associated with ectopic pregnancy. J Evidence Based Med Health Care. 2015;2(19):2700-8.
22. Mehta D, Kukadiya DS, Guru DM, Pandya DN. Ectopic tales of kachcch: A study of ectopic pregnancies. Int J Clin Obstet Gynaecol [Internet]. 2019;3(5):10-6.
23. Khatun RA, Hossain MM, Rahman M. Risk Factor of Ectopic Pregnancy in Rural Women Bangladesh.
24. Bouzari Z, Alizadeh M, Ghanbarpour A, Bijani A, Lakaei-andy F. The Risk Factors for Ectopic Pregnancy. Journal of Babol University of Medical Sciences. 2019;21(1):166-73.
25. Islam A, Fawad A, Shah AA, Jadoon H, Sarwar I. Analysis of two years cases of ectopic pregnancy. Journal of Ayub Medical College Abbottabad. 2017 Jan 25;29(1):65-7.
26. Barik S, Malakar A, Laha S. Trends in Ectopic Pregnancy: A Prospective Observational Study from a Tertiary Care Center in Eastern India. Journal of South Asian Federation of Obstetrics and Gynaecology. 2021 Feb 10;12(3):172-7.
27. Ranji GG, Usha Rani G, Varshini S. Ectopic pregnancy: risk factors, clinical presentation and management. The Journal of Obstetrics and Gynecology of India. 2018 Dec;68:487-92.
28. Govada N, KoNKay K, Pola N, devi ChaGaNti P. Clinical and Histopathological Findings of Ectopic Pregnancy Cases-A Retrospective Study from a Tertiary Care Hospital, Andhra Pradesh, India. National Journal of Laboratory Medicine. 2022 Jul, Vol-11(3): PO31-PO35
29. Swarnkar GP, Mishra M, Charles S, Sharma A, Sony A, Gaur K. Clinico-epidemiology and outcome of ectopic pregnancy: An experience of 7 years in St. Stephen’s hospital, Delhi.
30. Oguejiofor CB, Ezugwu CJ, Eleje GU, Emeka EA. Ruptured Ectopic Pregnancy in a Nigerian Tertiary Hospital: What has Changed?. International Journal. 2020;8:15.
31. Panda SR, Rani A, Meena M. Clinicosociodemographic profile of ruptured ectopic pregnancies at a tertiary care centre. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 2017 May 1;6(5):1885-90.
32. Kale P, Jangale K. Tubal Ectopic Pregnancy–A Clinical Study. British Journal of Medical & Health Sciences (BJMHS). 2020 Mar;2(3).
33. Ugboma HA, Oputa OA, Orazulike NC, Allagoa DO. Ectopic pregnancy: recent experience in a tertiary hospital, South-Southern Nigeria. parity. 2017; 149:100.
34. Ahmed MI, Begum Z. A Study on Histopathological Findings in Ectopic Tubal Pregnancies and Evaluation of Associated Risk Factors. Indian Journal of Pathology: Research and Practice. 2018;7(8):928.
35. Ravindra S, Prasad S, Suguna BV. Histomorphology of fallopian tubes in ectopic pregnancy. Archives of Medicine and Health Sciences. 2016 Jul 1;4(2):201.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Khalida Depar
Lecturer of Anatomy, Liaquat University of Medical & Health Sciences Jamshoro
Saima Gaffar
Assistant Professor of OBG. Liaquat University Hospital
Samreen Memon
Professor of Anatomy, Liaquat University of Medical & Health Sciences Jamshoro
Pushpa Goswami
Professor of Anatomy, Liaquat University of Medical & Health Sciences, Jamshoro
Farhana Rajpar
Associate Professor of Anatomy, Liaquat University of Medical & Health Sciences Jamshoro
Barkha Goswami
House officer Liaquat University Hospital.